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        Industrial by-product utilized synthesis of mesoporous aluminum silicate sorbent for thorium removal

        Sarah Alharthi,Mahmoud Osman Abd El-Magied 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.11

        Recently, there has been an increasing concern in finding sorbents for radionuclide removal from natural sources. AS-BFS sorbent (aluminum silicate composites derived from blast furnace slag) is a suitable candidate for this purpose; due to economic and environmental reasons. Blast furnace slag (BFS) is a by-product of the iron and steel industry plants. The development of a cost-effective route for recycling and utilization assessment of BFS is an urgent task. AS-BFS was prepared from BFS and its physicochemical properties were determined. The elemental composition of the AS-BFS is mainly oxygen (44%), Si (34%), and Al (19%), with traces of titanium, iron, chloride, and calcium. Experimental potentiality regarding sorption characteristics of AS-BFS to thorium ions was explored via the batch method. AS-BFS showed good adsorption capacity for thorium (obtained after 240 min) from aqueous streams (39.7 mg/g). The sorption process is fitted to the mono-layer adsorption model at optimum conditions. It was also proved that adsorption kinetics follows the pseudo-second-order model. The desorption results revealed that thorium ions (93%) could be eluted using 1M HNO3. Hence, the research work indicates that the thorium sorption method with AS-BFS is cost-effective, efficient, and recommended for thorium removal from natural sources.

      • Tissue CA125 and HE4 Gene Expression Levels Offer Superior Accuracy in Discriminating Benign from Malignant Pelvic Masses

        Fawzy, Amal,Mohamed, Mohamed R,Ali, Mohamed AM,El-Magied, Mohamed H Abd,Helal, Amany M Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1

        Background: Ovarian cancer remains a major worldwide health care issue due to the lack of satisfactory diagnostic methods for early detection of the disease. Prior studies on the role of serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) in detecting ovarian cancer presented conflicting results. New tools to improve the accuracy of identifying malignancy are urgently needed. We here aimed to evaluate the diagnostic utility of tissue CA125 and HE4 gene expression in comparison to serum CA125 and HE4 in discriminating benign from malignant pelvic masses. Materials and Methods: One-hundred Egyptian women were enrolled in this study, including 60 epithelial ovarian cancer (EOC) patients and 20 benign ovarian tumor patients, as well as 20 apparently healthy women. Preoperative serum levels of CA125 and HE4 were measured by immunoassays. Tissue expression levels of genes encoding CA125 and HE4 were determined by quantitative real time polymerase chain reaction (qRT-PCR). The diagnostic performance of CA125 and HE4, measured either as mRNA or protein levels, was evaluated by receiver operating characteristic (ROC) curves. Results: The serum CA125+HE4 combination and serum HE4, with area under the curve (AUC) values of 0.935 and 0.932, respectively, performed significantly better than serum CA125 (AUC=0.592; P<0.001). Tissue CA125 and HE4 (AUC=1) performed significantly better than serum CA125 (P<0.001), serum HE4 (P=0.016) and the serum CA125+HE4 combination (P=0.018). Conclusions: Measurement of tissue CA125 and HE4 gene expression not only improves discriminatory performance, but also broadens the range of differential diagnostic possibilities in distinguishing EOC from benign ovarian tumors.

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