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Seo, Eun-Hye,Song, Ga-Yun,Kwak, Byung Ok,Oh, Chung-Sik,Lee, Seung Hyun,Kim, Seong-Hyop Lippincott Williams and Wilkins 2017 Shock Vol.48 No.3
<P>Background: This study investigated the effects of glycyrrhizin (GR) on the ratio of myeloid-derived suppressor cells (MDSCs) to cluster of differentiation (CD) 11b+Gr1 myeloid cells in the heart and lungs in lipopolysaccharide (LPS)-induced septic mice. Methods: Mice were divided into three groups: Control, LPS, and LPS+GR. After intraperitoneal injection of phosphate-buffered saline for the Control group, LPS for the LPS group, and a combination of LPS and GR for the LPS+GR group, fluorescence-activated cell sorting was utilized to evaluate cytokines and immune cells in the blood, heart, and lungs. Histopathologic analysis of Toll-like receptor (TLR) 4 was also performed. Results: The cytokine amounts in the LPS and LPS+GR groups were significantly higher than in the Control group; however, that in the LPS+GR group was significant lower than in the LPS group. The ratio of MDSCs to CD11b+Gr1 myeloid cells in the LPS+GR group was significantly higher than in the LPS group but was significantly lower than in the Control group. The staining intensity of TLR4 showed the same pattern as that of cytokines in the heart and lungs. TLR4 staining was significantly lower in the LPS+GR group than in the LPS group but was higher than that in the Control group. Conclusion: GR exhibited protective effects on the heart and lungs in LPS-induced septic mice. The effects were associated with an elevated ratio of MDSCs to CD11b+Gr1 myeloid cells and the inhibition of cytokine release and TLR4 expression after GR injection.</P>
Seo, Sung-Keum,Jin, Hyeon-Ok,Lee, Hyung-Chahn,Woo, Sang-Hyeok,Kim, Eun-Sung,Yoo, Doo-Hyun,Lee, Su-Jae,An, Sungkwan,Rhee, Chang-Hun,Hong, Seok-Il,Choe, Tae-Boo,Park, In-Chul American Society for Pharmacology and Experimental 2008 Molecular pharmacology Vol.73 No.3
<P>Histone deacetylase (HDAC) inhibitors represent a promising group of anticancer agents. Treatment of cancer cells with HDAC blockers, such as suberoylanilide hydroxamic acid (SAHA), leads to the activation of apoptosis-promoting genes. To enhance proapoptotic efficiency, SAHA has been used in conjunction with radiation, kinase inhibitors, and cytotoxic drugs. In the present study, we show that at the suboptimal dose of 250 muM, sulindac [2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]-acetic acid] significantly enhances SAHA-induced growth suppression and apoptosis of A549 human non-small cell lung cancer cells, primarily via enhanced collapse of the mitochondrial membrane potential, release of cytochrome c, and caspase activation. Furthermore, sulindac/SAHA cotreatment induced marked down-regulation of survivin at both the mRNA and protein levels and stimulated the production of reactive oxygen species (ROS), which were blocked by the antioxidant N-acetyl-l-cysteine. Overexpression of survivin was associated with reduced sulindac/SAHA-induced apoptosis of A549 cells, whereas suppression of survivin levels with antisense oligonucleotides or small interfering RNA further sensitized cells to sulindac/SAHA-induced cell death. Our results collectively demonstrate that sulindac/SAHA-induced apoptosis is mediated by ROS-dependent down-regulation of survivin in lung cancer cells.</P>
Castillo-Morales Appliance Therapy in a Drooling Child with Intellectual Disability
Seo Young Shin,Ko Eun Lee,Mi Sun Kim,Ok Hyung Nam,Sung Chul Choi,Hyo-Seol Lee Asia Association for Disability and Oral Health 2021 대한장애인치과학회지 Vol.17 No.1
The Castillo-Morales Appliance, an oral appliance similar to an orthodontic retainer, consists of labial bow, palatal wire and rotating beads. The Castillo-Morales Appliance Therapy (CMAT) has been well established for use in patients with various forms of developmental delay. The CMAT features encourage dorsal elevation of the tongue and horizontal movement of the upper lip as well as the tip of the tongue. This case report presented the treatment of a drooling child with an intellectual disability. The patient also had open bite tendency, mouth breathing, lip incompetency, and tongue thrusting habit. Along with CMAT, a gradual process in tongue and lip movement was shown. Anterior open bite decreased while normal occlusion was obtained. Regular check-ups displayed improvements in drooling and orofacial functions.
Ok Hwan Cha,Cheol-Hoi Kim,Jun Seok Lee,Jong Pil Jeong,Joong Seo Park,Jandi Kim,정현,Eun-Kyung Suh 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1
The temperature dependence of the electroluminescence spectra of InGaN/GaN multi-quantumwell light-emitting diodes (LEDs) has been investigated over a range of temperatures and currents. The presence of localization effects in the active InGaN layers can be deduced from the observed considerable blue shifts of the electroluminescence emission peak with increasing temperature in the low-temperature region. Exciton-phonon couplings in the active layer are also observed at low temperatures. The electroluminescence intensity was measured to determine the internal quantum efficiency of the LEDs as a function of temperature. When the temperature decreases from room temperature to 170~200 K, the electroluminescence intensity increases due to a reduction in the nonradiative recombination, and the internal quantum efficiency is improved. At T < 170 K, the electroluminescence intensity is reduced significantly. This reduction of the electroluminescence intensity mainly results from the low carrier capture efficiency in the active layer due to the high Mg activation energy, the electron-hole separation in multi quantum wells, and the high internal piezoelectric field. However, in the case of LEDs using a narrow barrier, the electroluminescence intensity is reduced slightly at low temperatures. Therefore, in order to measure the internal quantum efficiency by using the temperature dependence of the electroluminescence spectra in LEDs, one must carefully consider the effects of carrier injection at low temperature.
Eun Soo Kim,Kyeong Ok Kim,Byung Ik Jang,이창균,Hyo Jong Kim,Kang-Moon Lee,김유선,Chang Soo Eun,Sung-Ae Jung,Suk-Kyun Yang,Jun Lee,Tae-Oh Kim,Yunho Jung,Geom Seog Seo,Soon Man Yoon,IBD Study Group of the Kor 거트앤리버 소화기연관학회협의회 2016 Gut and Liver Vol.10 No.3
Background/Aims: Two comparable anti-tumor necrosis factor (TNF) agents with different routes of administration (intravenous [iv] infliximab [IFX] vs subcutaneous [sc] adalimumab [ADA]) are available for patients with Crohn’s disease (CD) in Korea. This study aimed to identify the preferences of Korean CD patients for a specific anti-TNF agent and the factors contributing to the decision. Methods: A prospective survey was performed among anti-TNF-naive CD patients in 10 tertiary referral hospitals. A 16-item questionnaire addressed patient preferences and the factors contributing to the decision in favor of a particular anti-TNF agent. A logistic regression was conducted to assess predictive factors for ADA preference. Results: Overall, 189 patients (139 males; mean age, 32.47±11.71 years) completed the questionnaire. IFX and ADA were preferred by 63.5% (120/189) and 36.5% (69/189) of patients, respectively. The most influential reason for choosing IFX was ‘doctor’s presence’ (68.3%, 82/120), and ADA was “easy to use” (34.8%, 24/69). Amid various clinicodemographic data, having a >60-minute travel time to the hospital was a significant independent predictive factor for ADA preference. Conclusions: A large number of anti-TNF-naive Korean patients with CD preferred anti-TNFs with an iv route of administration. The reassuring effect of a doctor’s presence might be the main contributing factor for this decision.