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Jin, Xing,Zhang, Chunbo,Jin, Dongri,Lee, Yong-Ill Elsevier 2018 Microchemical journal Vol.143 No.-
<P><B>Abstract</B></P> <P>The enantioselective analytical method for trace ketoprofen (KET) in human saliva was developed for the first time using liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) combined with a derivatization using a chiral reagent, (<I>S</I>)‑1‑methyl‑4‑(5‑(3‑aminopyrrolidin‑1‑yl)‑2,4‑dinitro‑phenyl)piperazine (APy‑PPZ). The APy‑PPZ derivatization enabled highly sensitive detection (detection limit, 0.5 fmol on column) and complete separation with high resolution (R<SUB>s</SUB> = 4.3) of KET enantiomers. The calibration curves of both KET enantiomers in saliva were linear in the concentration range of 5–500 nM. The developed method showed good analytical performance with relative standard deviations (RSDs) below 2.6% and good accuracy (100.5–105.9%) through intra- and inter-assay and gave a potential for practical application to the quantitative determination of KET in human saliva.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A highly sensitive LC/ESI-MS/MS method for enantioselective analysis of KET was developed and validated. </LI> <LI> The proposed method was successfully applied to enantioselective determination of KET in human saliva for the first time. </LI> <LI> Good analytical performance of the method with very low LODs of 0.5 fmol and high recoveries of 100.5–105.9%. </LI> </UL> </P>
Jin, Dongri,Sakthivel, Kavitha,Gandhi, Sakthivel,Huy, Bui The,Lee, Yong-Ill Elsevier 2016 Sensors and actuators. B, Chemical Vol.237 No.-
<P><B>Abstract</B></P> <P>We have studied the electrochemical and optical properties of europium; a rare-earth ion functionalized ordered hybrid mesoporous silica material and evaluated its potential application for a non-enzymatic hydrogen peroxide sensor. Europium ion was introduced into the organic-inorganic hybrid mesoporous channels through complexation method. The modifications were confirmed by FT-IR whereas; the structural and textural properties of mesoporous silica are evaluated using FE-SEM, FE-TEM, and nitrogen physisorption isothermal analysis. The optical properties such as the excitation and emission behavior of rare-earth ion introduced ordered mesoporous silica was investigated using photoluminescence spectroscopy. The material is also evaluated for its electrochemical properties by the way of sensing H<SUB>2</SUB>O<SUB>2</SUB> in aqueous samples by using cyclic voltammetry and chronoamperometry. It showed a linear range between 1.0 and 1400μM. The response time of 4s is also observed with a detection limit of 0.5μM. It showed a good reproducibility, high stability and anti-interference ability which are considered vital for any electrochemical applications. The results obtained were quite challenging and thus, it has been applied for the detection of hydrogen peroxide in the presence of commercial disinfectant sample with satisfying results.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Design of novel europium incorporated mesoporous material for H<SUB>2</SUB>O<SUB>2</SUB> detection. </LI> <LI> Good analytical performance with non-interferent ability. </LI> <LI> A quick response time of <4s and low detection limit of 0.5μM. </LI> <LI> Successful detection of H<SUB>2</SUB>O<SUB>2</SUB> in the presence of disinfectant samples. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>