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Derakhshan Alireza,Sadeghi Masoumeh,Asnaashari Amir-Mohammad-Hashem,Dehghani Mohsen,Salari Roshanak,Khadem-Rezaiyan Majid,Mirsadraee Majid,Saeidinejat Shahin,Jalali Shima,Jalali Shabnam 대한약침학회 2023 Journal of pharmacopuncture Vol.26 No.2
Objectives: The present study was designed to conduct a comprehensive systematic review and meta-analysis to assess the efficacy of herbal medicines as add-on therapy on lung function in asthmatic patients. Methods: A comprehensive search of online databases was performed up to December 2021 to identify randomized controlled trials that used orally herbal preparations for asthma as add-on therapy. Studies were assessed for methodological quality using the Cochrane Collaboration’s Risk of Bias tool. The main outcome was percent predicted value of forced expiratory volume (% predicted FEV1). Pooled weighted mean difference (WMD) estimate with corresponding 95% confidence interval (CI) was calculated using inversevariance weights method while random effects meta-analysis was used, taking into account clinical and conceptual heterogeneity. Results: As a result, 1,525 studies were identified. 169 studies were reviewed in-depth and 23 studies met our systematic review inclusion criteria. Finally, nine randomized controlled trials were included in the meta-analysis. Findings indicated that use of herbal medicines in patients with asthma significantly improved % predicted FEV1 (WMD: 3.73, 95% CI: 1.76-5.70), with no evidence for significant heterogeneity (p = 0.56 [Q statistic], I 2 = 0.0%). In subgroup analysis by age, improvement in % predicted FEV1 was higher and significant in adults (WMD: 5.16; 95% CI: 2.68-7.63) compared to children (WMD = 1.27; 95% CI: −1.98-4.51). Sensitivity analysis showed the significant effect of herbal medicine consumption on improving FEV1 was consistently (range of summary WMDs: 3.27-4.59), indicating that the meta-analysis model was robust. There was no evidence of publication bias both visually and statistically. Conclusion: Findings support, the complementary use of herbal medicines resulted in significant improvement in the lung function compared to standard treatment in asthmatic patients with no considerable adverse events. This improvement is more likely to be observed amongst adults.
Derakhshan Ali Reza,Saeidinejat Shahin,Khadem-Rezaiyan Majid,Asnaashari Amir-Mohammad-Hashem,Mirsadraee Majid,Salari Roshanak,Jabbari-Azad Farahzad,Jalali Shima,Jalali Shabnam 대한약침학회 2022 Journal of pharmacopuncture Vol.25 No.3
Objectives: Asthma is a chronic disease, and the demand for herbal medicines in this field has increased in recent years. The new findings highlight the role of the gut-lung axis in the pathophysiology of asthma. Hence, this study will evaluate the safety and efficacy of Glasthma syrup, an herbal formula based on Persian medicine, in improving asthma and regulating intestinal permeability. The formula consists of five herbal ingredients that have anti-inflammatory effects on the respiratory tract, also known as gut tonics. Methods: The study will be conducted as a placebo-controlled, triple-blind, randomized trial. It will consist of a 4-week intervention followed by a 4-week follow-up period. The target sample size is 20 patients with moderate asthma aged 18 to 60 years. Eligible participants will be randomly assigned to either the experimental group or the control group in equal numbers. Patients in the experimental group will take Glasthma syrup (7.5 mL, twice a day), while patients in the control group will take a matching placebo. Both groups will receive a 4-week combination of a long-acting beta2 agonist and a leukotriene modulator as standard of care. Inhaled corticosteroids can be used as rescue medication as needed. Results: The primary outcomes are asthma symptom scale, lung function, and intestinal permeability. Secondary outcomes include quality of life, symptom recurrence rates, and blood tests. A safety assessment will also be conducted during the trial. Conclusion: In this trial, the effects of Glasthma syrup in patients with moderate asthma will be examined. The study will also assess the effects of the formulation on the gut-lung axis by simultaneously monitoring the gut permeability index, asthma symptoms, and lung function.
Zahra Derakhshan,Mohammad Hassan Ehrampoush,Amir Hossein Mahvi,Mansooreh Dehghani,Mohammad Faramarzian,Mohammad Taghi Ghaneian,Mehdi Mokhtari,Ali Asghar Ebrahimi,Hossein Fallah Zadeh 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.67 No.-
The present study examined a moving bed biofilm reactor (MBBR) bioreactor on a laboratory scale for simultaneous removal of atrazine, organic carbon, and nutrients from wastewater. The maximum removal efficiency of atrazine, chemical oxygen demand (COD), total phosphorus (TP) and total nitrogen (TN) were 83.57%, 90.36%, 90.74% and 87.93 respectively. Increasing salinity up to 40 g/L NaCl in influent flow could inhibit atrazine biodegradation process strongly in the MBBR reactor.Results showed that MBBR is so suitable process for efficiently biodegrading of atrazine and nitrogen removal process was based on the simultaneous nitrification-denitrification (SND) process.
Comparison between Tear Film Osmolar Cocentration and Other Tear Film Function Parameters
akbar derakhshan,arash omidtabrizi,majid abrishami,mohamad khajedaluee,somayeh ghassemi moghaddam 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.4
Purpose: To evaluate tear film function in patients with diabetes mellitus (DM) using tear film osmolarity (TFO)measurements compared to other tear film function tests. Methods: DM patients without any history of ocular surface disorder but with potential effects on the tear filmwere enrolled in this cross-sectional study. Data including dry eye symptoms, duration of DM, stage of diabeticretinopathy and blood hemoglobin A1c levels were recorded. Tear film break-up time (TBUT) and basic tearsecretion (Schirmer test) were assessed. TFO was determined using the Tearlab Osmolarity System. The outcomemeasures were the difference between the mean values of TBUT, basic tear secretion and TFO in boththe study and control groups. Results: We recruited 51 DM patients and 20 control subjects with a mean age of 51.2 (range, 21 to 70) and48.5 (range, 24 to 70) years, respectively. A total of 27 patients (53%) and 11 controls (55%) reported dry eyesymptoms (p = 0.668). The mean TBUT was 10.2 + 4.8 seconds in the study group versus 10.5 + 2.8 secondsin controls, which was not significantly different (p = 0.747). The mean Schirmer test score was 8.1 + 4.3 mmin the patients versus 10.1 + 3.0 mm in the controls (p = 0.069). The mean TFO was 294.1 + 12.9 mosmol/Lin the patients versus 291.4 + 14.5 mosmol/L in the controls (p = 0.456). It was significantly higher in patientswith poor glycemic control determined by hemoglobin A1c > 8% (p = 0.003). TFO had a positive correlationwith the duration of DM (p = 0.030) but not with the stage of diabetic retinopathy (p = 0.944). However, TFOshowed a significant relationship with dry eye symptoms (p = 0.001). Conclusions: TFO is impaired in patients with uncontrolled DM and is better correlated with glycemic controland dry eye symptoms than the TBUT and Schirmer tests.
Zahra Derakhshan Nejad,김정욱,정명채 한국지질과학협의회 2017 Geosciences Journal Vol.21 No.3
Arsenic (As) is a known carcinogen and is one of the most commonly reported contaminants in farmland soils around mining sites. This study aimed to investigate four different soil amendments (rice husk biochar (RHB), maple leaf biochar (MLB), red mud (R.M), and steel slag (S.S)) with respect to the stabilization of arsenic in soil combined with revegetation of two hyperaccumulators (Asteraceae (lettuce) and Brassicaceae (mustard green)). Soil amendments at different application rates (0.5%, 1%, and 2% w/w) and small particle sizes (<74 μm) were added to the soil. A different pattern was observed for stabilization of As in treated soils. A meaningful decline in As stabilization was observed with increasing application dosage of MLB, R.M, and S.S, while in case of RHB efficiency was increased. Generally, maximum stabilization efficiency of As was observed following the adding of RHB (2%), MLB (0.5%), R.M (0.5%), and S.S (0.5%), by 90%, 94%, 94%, and 89%, respectively, which was primarily attributed to amendmentsinduced specific surface area within the structure. For lettuce, As was strongly accumulated by leaves, while As, for mustard green, was extracted much more by its roots. Sequential extraction analysis confirmed high proportions of Fe and Mn oxides and organic fractions of As, before and after planting. Altogether, the establishment of a suitable plant cover on treated soil with amendments showed encouraging results for preventing the dispersion of As through runoff and percolation. Besides, this combined technique, which is aesthetically pleasant, increases biodiversity.