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James W. Daily,고병섭,육지나,Meiling Liu,Weijun Zhang,박선민 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.2
Soy isoflavones may benefit some, but not all, menopausal women, and the ability of the women to produce equol may be the major determinant of effectiveness. We assessed the efficacy of soy isoflavones and equol for alleviating menopausal symptoms, especially vasomotor symptoms, in postmenopausal women who were equol producers and nonproducers by using systematic review and meta-analysis of randomized clinical trials (RCTs). We searched 12 English, Korean, and Chinese language scientific and medical databases. We selected all available RCTs that assessed the effect of equol, either equol itself or soy isoflavone in equol producers, on menopausal symptoms in peri- or postmenopausal women. The primary outcome was the effect on hot flashes. The severity of hot flashes was determined by the scores, and sensitivity and risk of bias analyses were conducted. Other outcomes of the review, but not meta-analysis, included depression and adverse events. Six studies (779 total subjects) met all criteria for the systematic review, 5 of those could be included in the meta-analysis (728 total subjects). Two studies included in the meta-analysis reported no statistically significant benefits of equol; the other three did report significant benefits of equol. Meta-analysis revealed a significant benefit of equol for lowering hot flash scores and revealed a generally low risk of bias. In conclusion, this study found that supplementing equol to equol nonproducers significantly lowered the incidence and/or severity of hot flashes in menopausal women.
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Effect of Freeze-Thaw Cycles on Dynamic Characteristics of Undisturbed Silty Clay
Gao Hang Cui,Zhuo Cheng,Daili Zhang,Shuxian Ma,Zhiqiang Liu 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9
We conducted dynamic triaxial tests of undisturbed soil samples under different control parameters using the Global Digital Systems (GDS) dynamic triaxial instrument. We investigated the dynamic and engineering characteristics of undisturbed soil under a freeze–thaw cycle. When the dynamic load amplitude and the number of freeze–thaw cycles were adjusted, we explored the cumulative plastic strain, dynamic elastic modulus, and dynamic strength of undisturbed soil, and we then proposed appropriate fitting formulae to compute the cumulative plastic strain, dynamic elastic modulus, and dynamic strength. The findings revealed that as the number of freeze–thaw cycles increased, the cumulative plastic strain grew, the dynamic strength progressively fell, and the dynamic elastic modulus dropped first, but then increased. The critical physical and dynamic features of soil changed dramatically during one to six freeze–thaw cycles. This study’s suggested formula for the average growth ratio can directly reflect the cumulative plastic strain fluctuation of soil throughout freeze–thaw cycles. The formula has a good fitting effect on undisturbed soil, according to the test findings, and the accumulative plastic strain, dynamic elastic modulus, and dynamic strength may be computed within a specified range. The findings of this study contribute to a better understanding of the effect of the freeze–thaw cycle on the dynamic characteristics of undisturbed silty clay, as well as a theoretical foundation for the design and construction of silty clay highway subgrade in seasonally frozen regions as well as the dynamic analysis of vehicle simulation in seasonally frozen regions.
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