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Ran Li,Kunchi Zhao,Qing Ruan,Chunyang Meng,Fei Yin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Spinal cord injury after surgical repair of the thoracic or thoracoabdominal aorta is a devastating complication that is associated with pathological changes, including inflammation, edema, and nerve cell damage. Recently, microRNA (miRNA)-modulated control of spinal cord injury has been actively investigated. This study aims to clarify the regulatory effect of miR-214-mediated inhibition of Kcnk2 following spinal cord ischemia-reperfusion injury (SCII) and the possible underlying mechanisms. SCII was induced in rats by occluding the aortic arch followed by reperfusion. Gain-of-function and loss-of-function experiments were conducted to explore the modulatory effects of Foxd3, miR214 and Kcnk2 on PC12 cells under hypoxia/reoxygenation (H/R) conditions. MiR-214 and Kcnk2 were poorly expressed, while Foxd3 was highly expressed in the rat spinal cord tissues and H/R-treated PC12 cells. Kcnk2 overexpression enhanced the viability and inhibited the apoptosis of the H/R-treated PC12 cells. Notably, Foxd3 activated miR-214, and miR-214 targeted Kcnk2. In addition, upregulation of Kcnk2 or knockdown of Foxd3 promoted the cell viability and reduced the apoptosis of the H/R-treated PC12 cells. Overall, our study identified a novel mechanism of Foxd3/miR-214/Kcnk2 involving SCII, suggesting that either Foxd3 or miR-214 may be a novel target for the treatment of SCII.
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Chen Xiuling,Mo Fulei,Shen Chunyang,Meng Lingjun,Zou Yuxin,Xue Xiaopeng,Cheng Mozhen,Meng Fanyue,Qi Haonan,Wang Aoxue 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.6
NAC proteins in plants respond to stress and play an important role in plant growth regulation. This regulation occurs through a variety of downstream eff ects mediated by plant hormones in response to stress. In this study, we performed a systematic genome-wide analysis of the NAC gene family in tomato based on genome version SL4.0. We identifi ed 99 SlNAC genes by abiotic stress analysis of conserved motifs and gene structure, phylogenetic analysis, cis-element analysis, chromosome localization analysis, synteny relationship and expression pattern analysis. These 99 SlNAC genes were distributed on all 12 chromosomes. Except for genes without introns, there was no signifi cant correlation between gene structures and phylogenetic relationships. Most of the cis-elements identifi ed were associated with plant hormones and environmental responses. There were 77 SlNAC genes that showed no homogeneity between tomato and wild rice, suggesting that these homologous genes arose after the diff erentiation of dicotyledonous and monocotyledonous plants. The comprehensive analysis of the SlNAC gene family provides a valuable resource for studying this gene family in tomato and a foundation for further study of the functional characteristics of these genes.
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