http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Dubaele, Sandy,Martin, Christophe,Bohn, Jacqueline,Chene, Patrick Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.1
Helicases are ubiquitous enzymes, which utilize the energy liberated during nucleotide triphosphate hydrolysis to separate double-stranded nucleic acids into single strands. These enzymes are very attractive targets for the development of new antibacterial compounds. The PcrA DNA helicase from Staphylococcus aureus is a good candidate for drug discovery. This enzyme is unique in the genome of S. aureus and essential for this bacterium. Furthermore, it has recently been published that it is possible to identify inhibitors of DNA helicases such as PcrA. In this report, we study the properties of recombinant PcrA from S. aureus purified from Escherichia coli to develop ATPase and helicase assays to screen for inhibitors.
Research on the cone angle and clearance of main pump seal
Wang Heshun,Zhu Weibing,Huang Zepei,Zhang Chening,Zhang Junkai 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.7
For better film characteristics of the main pump seal (MPS), a theoretical calculation model was proposed based on the Reynolds equation. A case study with defined MPS was carried out, film stiffness was taken as the basic constraint condition, and the cone angle andclearance are two optimization targets. When the film stiffness reaches a maximum, the corresponding cone angle and clearance is theoptimal value. The results show that: (1) film stiffness increased and decreased with clearance and cone angle, respectively; (2) the optionalclearance was determined to be within a range of 2~8 μm at a cone angle of between 0.1~1.2'; (3) the maximum of film stiffness isinversely proportional to the cone angle (Clearance) approximately under the clearance (Cone angle) is fixed; (4) leakage is directly proportionalto the clearance to power three, and the clearance has greater influence on the amount of leakage than the cone angle. Theseresults provide a reliable theoretical justification for MPS-based designs including optimization method. It therefore forms a fundamentalbase for research and practical application.