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      • KCI등재

        Electrical and Mechanical Properties of Epoxy Composites Reinforced with Kaolin-Coated Basalt Fibers

        He-Chen Liu,Yu Sun,Mingjia Zhang,Yun-Peng Liu,Yunfei Yu,Hong Yu 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1

        Basalt fiber (BF) is appropriately used for manufacturing insulating rods because of its excellent aging resistance, hightemperature resistance, electrical insulation, and mechanical strength. However, due to the inert structure on the surface ofthe fiber, the close bonding between the fiber and the resin is hindered. The low bonding strength of the fiber/resin interfacewill significantly reduce the mechanical and insulation properties of the composite, which limits its application in electricalequipment such as insulating rods and insulators. Therefore, this paper attempts to improve the surface roughness of BF byusing Kaolin to strengthen the bonding strength between BF and matrix resin, and analyze and study the mechanical and insulationproperties of the composites before and after modification. The Kaolin content coated on BF ranged from 0.5 to 2 wt%,and the composites modified by 1.5wt%Kaolin (1.5-wt%-K-BFRP) exhibited excellent electrical insulation and mechanicalperformance. Compared with untreated BFRP, the electrical breakdown strength and flashover voltage of 1.5-wt%-K-BFRPincreased by 18.49% and 10.69%, elevated to the 20.57 kV/mm and 13.04 kV, respectively, and the dielectric loss decreasedby 49%, down to 0.83%. The above results indicate that modified BFRP has excellent insulation strength and is suitable forthe manufacture of insulating devices. Furthermore, the bending strength, bending modulus, tensile strength, and interlayershear strength of 1.5-wt%-K-BFRP increased by 67.59%, 21%, 14.56%, and 103.7%, respectively, compared with untreatedBFRP, reach to 465.17 MPa, 31.49 GPa, 562.3 MPa, 26.44 MPa.

      • SCISCIESCOPUS
      • KCI등재

        Pretreatment Serum Amyloid A and C-reactive Protein Comparing with Epstein-Barr Virus DNA as Prognostic Indicators in Patients with Nasopharyngeal Carcinoma: A Prospective Study

        Qiu-Yan Chen,Qing-Nan Tang,Lin-Quan Tang,Wen-Hui Chen,Shan-Shan Guo,Li-Ting Liu,Chao-Feng Li,Yang Li,Yu-Jing Liang,Xue-Song Sun,Ling Guo,Hao-Yuan Mo,Rui Sun,Dong-Hua Luo,Yu-Ying Fan,Yan He,Ming-Yuan C 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3

        Purpose The measuring Epstein-Barr virus (EBV) DNA is an important predictor of nasopharyngeal carcinoma (NPC). This study evaluated the predictive value of pretreatment serum amyloid A (SAA) and C-reactive protein (CRP) comparing with EBV DNA in patients with NPC. Materials and Methods In an observational study of 419 non-metastatic NPC patients, we prospectively evaluated the prognostic effects of pretreatment SAA, CRP, and EBV DNA on survival. The primary endpoint was progress-free survival (PFS). Results The median level of SAA and CRP was 4.28 mg/L and 1.88 mg/L, respectively. For the high- SAA group (> 4.28 mg/L) versus the low-SAA ( 4.28 mg/L) group and the high-CRP group (> 1.88 mg/L) versus the low-CRP ( 1.88 mg/L) group, the 5-year PFS was 64.5% versus 73.1% (p=0.013) and 65.2% versus 73.3% (p=0.064), respectively. EBV DNA detection showed a superior predictive result, the 5-year PFS in the EBV DNA  1,500 copies/mL group was obviously different than the EBV DNA < 1,500 copies/mL group (62.2% versus 77.8%, p < 0.001). Multifactorial Cox regression analysis confirmed that in the PFS, the independent prognostic factors were including EBV DNA (hazard ratio [HR], 1.788; p=0.009), tumour stage (HR, 1.903; p=0.021), and node stage (HR, 1.498; p=0.049), but the SAA and CRP were not included in the independent prognostic factors. Conclusion The results of SAA and CRP had a certain relationship with the prognosis of NPC, and the prognosis of patients with high level of SAA and CRP were poor. However, the predictive ability of SAA and CRP was lower than that of EBV DNA.

      • SCIESCOPUSKCI등재

        Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration

        Chen, Yin Bin,Wang, Yu Fang,Hou, Wei,Wang, Ying Ping,Xiao, Sheng Yuan,Fu, Yang Yang,Wang, Jia,Zheng, Si Wen,Zheng, Pei He The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.2

        Background: Both ginsenoside Re and B-complex vitamins are widely used as nutritional supplements. They are often taken together so as to fully utilize their antifatigue and refreshing effects, respectively. Whether actually a drug-nutrient interaction exists between ginsenoside Re and B-complex vitamins is still unknown. The objective of this study was to simultaneously investigate the effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after their oral administration. The study results will provide valuable theoretical guidance for the combined utilization of ginseng and B-complex vitamins. Methods: Ginsenoside Re with or without B-complex vitamins was orally administered to mice to evaluate its antifatigue effects and to rats to evaluate its bioavailability. The antifatigue activity was evaluated by the weight-loaded swimming test and biochemical parameters, including hepatic glycogen, plasma urea nitrogen, and blood lactic acid. The concentration of ginsenoside Re in plasma was determined by liquid chromatography-tandem mass spectrometry. Results: No antifatigue effect of ginsenoside Re was noted when ginsenoside Re in combination with B-complex vitamins was orally administered to mice. B-complex vitamins caused to a reduction in the bioavailability of ginsenoside Re with the area under the concentration-time curve from zero to infinity markedly decreasing from $11,830.85{\pm}2,366.47h{\cdot}ng/mL$ to $890.55{\pm}372.94h{\cdot}ng/mL$. Conclusion: The results suggested that there were pharmacokinetic and pharmacodynamic drug-nutrient interactions between ginsenoside Re and B-complex vitamins. B-complex vitamins can significantly weaken the antifatigue effect and decrease the bioavailability of ginsenoside Re when simultaneously administered orally.

      • SCOPUSKCI등재
      • miR-126 Suppresses the Proliferation of Cervical Cancer Cells and Alters Cell Sensitivity to the Chemotherapeutic Drug Bleomycin

        Yu, Qing,Liu, Shan-Ling,Wang, He,Shi, Gang,Yang, Pei,Chen, Xin-Lian Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

        In cervical cancer, one of the most common malignant tumors in women worldwide, miR-126 has been reported to exhibit decreased expression. However, its role in cervical cancer cell proliferation and drug sensitivity has remained relatively unexplored. Here, we compared the expression of miR-126 in cervical cancer tissues (n = 20) with that in normal cervical tissue (n = 20) using quantitative RT-PCR. The viability of Siha cervical cancer cells was further measured by MTT assay after transfection with miR-126 mimic (Siha-miR-126 mimic) or microRNA mimic negative control (Siha-miR mimic NC) and after treatment with various concentrations of bleomycin (BLM). IC50s were calculated, and the survival rates (SRs) of Siha cells were calculated. miR-126 expression in cervical cancer tissue was significantly decreased compared with that in normal cervical tissue (P < 0.01). The relative SRs of Siha-miR-126 mimic cells were also significantly decreased compared with those of Siha-miR mimic NC cells at 24-96 h after transfection. The IC50 of BLM in Siha-miR-126 mimic cells ($50.3{\pm}2.02{\mu}g/mL$) was decreased compared with that in Siha-miR mimic NC cells ($70.5{\pm}4.33{\mu}g/mL$) at 48 h after transfection (P < 0.05). Finally, the SRs of Siha-miR-126 mimic cells were significantly lower than those of SihamiR mimic NC cells after cultured in medium containing 40 ${\mu}g/mL$ BLM for 24-96 h (P < 0.05). These results suggest that miR-126 is expressed at low levels in cervical cancer. Upregulation of miR-126 inhibited cervical cancer cell proliferation and enhanced the sensitivity to BLM. Thus, miR-126 may represent a novel approach to cervical cancer treatment.

      • KCI등재

        Effects of different carbon sources on the phase composition and microstructure of synthesized SiC-B4C composite powders

        Yu Cao,Ruyi Deng,Jilin Hu,Jinxiu He,Dapeng Lei,Zhanjun Chen,Yangxi Peng 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.2

        SiC-B4C composite powders were synthesized by the carbothermal reduction method under an argon atmosphere usingdifferent kinds of carbon sources (carbon black and starch) and silica sol and boric acid as the precursor raw materials. Basedon thermodynamic analysis and calculation, the effects of different carbon sources and reaction temperatures on the mass lossrate, phase composition, and microstructure of SiC-B4C ultrafine composite powders were comparatively studied. Resultsshowed that the optimum conditions for synthesizing SiC-B4C composite powders with carbon black as the carbon source were1550 ºC for 2 h, whereas the optimum conditions for synthesizing SiC-B4C composite powders with starch as the carbon sourcewere 1450 ºC-1550 ºC for 2 h. The powder samples synthesized with carbon black as the carbon source at 1550 ºC were mainlycomposed of flaky, columnar-like, spherical, and irregular polyhedral particles (about 100-200 nm in diameter). Mutualcohesion or agglomeration between particles was minimal. In the powder samples synthesized at 1550 ºC with an excess of 10wt% starch, in addition to a certain amount of flaky, spherical, and other irregular structure particles, a certain amount ofuniform, slender whiskers (about 50-100 nm in diameter) and a certain phenomenon of lap and winding between the whiskerswere noted. The powder samples synthesized at 1550 ºC with an excess of 20 wt% starch had no whisker-like substance.

      • Pancreatic Cancer Incidence and Mortality Patterns in China, 2009

        Chen, Wan-Qing,Liang, Di,Zhang, Si-Wei,Zheng, Rou-Shou,He, Yu-Tong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

        Objective: To estimate the incidence and mortality rates for pancreatic cancer in China. Methods: After checking and reviewing the cancer registry data in 2009 from 72 cancer registry centers, we divided cancer registry areas into urban and rural areas. Incidence/mortality rates, age-specific incidence/mortality rates, age-standardized incidence/mortality rates, proportions, and cumulative incidence/mortality rates for pancreatic cancer were calculated. Results: The total number of newly diagnosed pancreatic cancer cases and deaths in 2009 were 6,220 and 5,650, respectively. The crude incidence rate in all cancer registry areas was 7.28/100,000 (males 8.24, females 6.29). The age-standardized incidence rate by Chinese standard population (ASR) was 3.35/100,000, with ranking at 7th among all cancers. Pancreatic cancer incidence rate was 8.19/100,000 in urban areas whereas it was 5.41/100 000 in rural areas. Cancer mortality rate in all cancer registry areas was 6.61/100,000 (males 7.45; females 5.75), with ranking at 6th among all cancers, and 7.42/100 000 in urban but 4.94/100000 in rural areas. Conclusions: Pancreatic cancer incidence and mortality rates have shown a gradual increase in China. Owing to the difficulty of early diagnosis, identification of high-risk population and modification of risk factors are important to reduce the burden of pancreatic cancer.

      • KCI등재

        A New Large-Scale Plane-Strain Permeameter for Gravelly Clay Soil under Stresses

        Yu-Hua Zou,Qun Chen,Chang-Rong He 대한토목학회 2013 KSCE JOURNAL OF CIVIL ENGINEERING Vol.17 No.4

        A large-scale plane-strain permeameter was designed to investigate the hydraulic characteristics of gravelly clay base soil and a filter under various stresses and different water heads. The apparatus provides a specimen size about 80 cm long, 40 cm wide and 40cm high. It is equipped with a horizontal and vertical loading system with capacities of 1000 kN in the horizontal direction and 2000kN in the vertical direction and a water pressure system which can provide water head up to 300 m. The components of the planestrain permeameter are described in detail in this paper. The performance of the permeameter is demonstrated through a group of tests on specimens combining gravelly clay soil and a filter.

      • SCIESCOPUSKCI등재

        Effects of raw meat and process procedure on N<sup>ε</sup>-carboxymethyl-lysine and N<sup>ε</sup>-carboxyethyl-lysine formation in meat products

        Yu, Ligang,Gao, Chang,Zeng, Maomao,He, Zhiyong,Wang, Linxiang,Zhang, Shuang,Chen, Jie 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.4

        This work aimed to investigate the effects of stored raw meat and process procedures on $N^{\varepsilon}$-carboxymethyl-lysine (CML) and $N^{\varepsilon}$-carboxyethyl-lysine (CEL) generation in meat products. Meat products of raw pork were sterilized and pasteurized at different storage times (0-4 months) and the CML/CEL contents were determined. The results showed that the extent of lipid and protein oxidation of raw pork increased with increasing storage time. A linear correlation was found between thiobarbituric acid-reactive substances value/carbonyl content and CML/CEL in sterilized meat products, indicating that stored raw pork could promote CML/CEL formation under high temperature processing. Furthermore, mild heating temperatures seemed to favor CML formation, while high temperature could accelerate CEL generation. Therefore, formation kinetics of CML and CEL might be different for different process procedures. These results suggested that stored raw meat and processing temperature could significantly affect CML and CEL generation in meat products.

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