Effects of Calcium Channel Blockers On Hyaluronidaseinduced Capillary Vascular Permeability

Halici, Zekai,Suleyman, Halis,Cadirci, Elif 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7

Inflammation and increased capillary permeability is a significant aspect of the pathogenesis of many diseases including atherosclerosis. L-type calcium channel blockers (CCB) are commonly used as cardiovascular drugs. Amlodipine, lacidipine, and nicardipine were evaluated for anti-inflammatory activity on the paw oedema produced by carrageenan. The effect of these drugs was compared with the activity of indomethacin. Their effects on vascular permeability were also tested by hyaluronidase-induced capillary permeability. In our animal experiments, amlodipine decreased the carrageenan-induced paw oedema at doses of 1, 3, and $6\;mg\;kg^{-1}$ by 27.3%, 43.7%, and 67.3% four hour after carrageenan administration; the same doses of lacidipine and nicardipine decreased paw oedema by 37.1%, 55.6%, 76.4%, 11.2%, 31.0%, 91%; and indomethacin decreased oedema by 38.2% at a dose of $6\;mg\;kg^{-1}$. Lacidipine significantly inhibited the hyaluronidase-induced increase in capillary permeability at doses of 1, 3, and $6\;mg\;kg^{-1}$ compared with the control group. However, amlodipine and nicardipine significantly inhibited the hyaluronidase-induced increase in capillary permeability at 3 and $6\;mg\;kg^{-1}$ doses. A $6\;mg\;kg^{-1}$ dose of indomethacin significantly decreased the capillary permeability which was increased by hyaluronidase. These results suggest that CCBs can be efficient anti-inflammatories, and can also significantly decrease capillary permeability.

A General Purpose Inverter Set-Up for Power Electronics Laboratory Experiments

Kayakesen, Mustafa Erman,Cadirci, Isik The Korean Institute of Power Electronics 2010 JOURNAL OF POWER ELECTRONICS Vol.10 No.4

A general purpose experimental set-up has been designed and implemented for students to carry out various experiments on inverters in the power electronics laboratories of universities, during a few hours of laboratory work. This is the first inverter setup that incorporates hardware and software control, as well as an optional user interface in a laboratory experimental set-up of a single multi-purpose inverter, thus making the system versatile and very practical for both undergraduate and graduate students. The system can be controlled either by a computer or through a liquid crystal display (LCD) and a keypad control unit, and it constitutes a low-cost alternative to relatively expensive commercial teaching sets. The computer provides a user friendly interface and easier control for laboratory environments equipped with computers. The LCD and keypad units eliminate the need for a computer, which makes this system usable in the laboratory as a standalone unit as well.

A General Purpose Inverter Set-Up for Power Electronics Laboratory Experiments

Mustafa Erman Kayakesen,Isik Cadirci 전력전자학회 2010 JOURNAL OF POWER ELECTRONICS Vol.10 No.4

A general purpose experimental set-up has been designed and implemented for students to carry out various experiments on inverters in the power electronics laboratories of universities, during a few hours of laboratory work. This is the first inverter setup that incorporates hardware and software control, as well as an optional user interface in a laboratory experimental set-up of a single multi-purpose inverter, thus making the system versatile and very practical for both undergraduate and graduate students. The system can be controlled either by a computer or through a liquid crystal display (LCD) and a keypad control unit, and it constitutes a low-cost alternative to relatively expensive commercial teaching sets. The computer provides a user friendly interface and easier control for laboratory environments equipped with computers. The LCD and keypad units eliminate the need for a computer, which makes this system usable in the laboratory as a standalone unit as well.

Effects of Calcium Channel Blockers On Hyaluronidaseinduced Capillary Vascular Permeability

Zekai Halici,Halis Suleyman,Elif Cadirci 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7

Inflammation and increased capillary permeability is a significant aspect of the pathogenesis of many diseases including atherosclerosis. L-type calcium channel blockers (CCB) are commonly used as cardiovascular drugs. Amlodipine, lacidipine, and nicardipine were evaluated for anti-inflammatory activity on the paw oedema produced by carrageenan. The effect of these drugs was compared with the activity of indomethacin. Their effects on vascular permeability were also tested by hyaluronidase-induced capillary permeability. In our animal experiments, amlodipine decreased the carrageenan-induced paw oedema at doses of 1, 3, and 6 mg kg-1 by 27.3%, 43.7%, and 67.3% four hour after carrageenan administration; the same doses of lacidipine and nicardipine decreased paw oedema by 37.1%, 55.6%, 76.4%, 11.2%, 31.0%, 91%; and indomethacin decreased oedema by 38.2% at a dose of 6 mg kg-1. Lacidipine significantly inhibited the hyaluronidase-induced increase in capillary permeability at doses of 1, 3, and 6 mg kg-1 compared with the control group. However, amlodipine and nicardipine significantly inhibited the hyaluronidase-induced increase in capillary permeability at 3 and 6 mg kg-1 doses. A 6 mg kg-1 dose of indomethacin significantly decreased the capillary permeability which was increased by hyaluronidase. These results suggest that CCBs can be efficient anti-inflammatories, and can also significantly decrease capillary permeability.

Gastroprotective and Antioxidant Effects of Amiodarone on Indomethacin-induced Gastric Ulcers in Rats

Dengiz, G Ozbakis,Odabasoglu, F.,Halici, Z,Suleyman, H,Cadirci, E,Bayir, Y 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11

Reactive oxygen species (ROS) have been implicated in the etiology of indomethacin-induced gastric mucosal damage. This study investigated amiodarone's protective effects against oxidative gastric mucosal damage induced by indomethacin. Amiodarone is a widely used antiarrhythmic agent. We have investigated alterations in the glutathione level, and the activities of antioxidative enzymes [superoxide dismutase, catalase, glutathione s-transferase glutathione reductase and myeloperoxidase], as markers for ulceration process following oral administration of amiodarone and ranitidine in rats with indomethacin-induced ulcers. In the present study we found that 1) amiodarone, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages, at a greater magnitude for amiodarone and lansoprazole than for ranitidine; 2) amiodarone and ranitidine alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from ulcers; 3) amiodarone and ranitidine ameliorated depressions in the glutathione level and the activities of superoxide dismutase and glutathione reductase enzymes caused by indomethacin administration; and 4) all doses of amiodarone amplified the myeloperoxidase activity resulting from indomethacininduced gastric ulcers. The results indicate that the gastroprotective activity of amiodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity.

Gastroprotective and Antioxidant Effects of Amiodarone on Indomethacin-induced Gastric Ulcers in Rats

G Ozbakis Dengiz,F. Odabasoglu,Z Halici, H Suleyman,E Cadirci,Y Bayir 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11

Reactive oxygen species (ROS) have been implicated in the etiology of indomethacin-induced gastric mucosal damage. This study investigated amiodarone's protective effects against oxidative gastric mucosal damage induced by indomethacin. Amiodarone is a widely used antiarrhythmic agent. We have investigated alterations in the glutathione level, and the activities of antioxidative enzymes [superoxide dismutase, catalase, glutathione s-transferase glutathione reductase and myeloperoxidase], as markers for ulceration process following oral administration of amiodarone and ranitidine in rats with indomethacin-induced ulcers. In the present study we found that 1) amiodarone, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages, at a greater magnitude for amiodarone and lansoprazole than for ranitidine; 2) amiodarone and ranitidine alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from ulcers; 3) amiodarone and ranitidine ameliorated depressions in the glutathione level and the activities of superoxide dismutase and glutathione reductase enzymes caused by indomethacin administration; and 4) all doses of amiodarone amplified the myeloperoxidase activity resulting from indomethacininduced gastric ulcers. The results indicate that the gastroprotective activity of amiodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity.