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REVISITING THE MICROLENSING EVENT OGLE 2012-BLG-0026: A SOLAR MASS STAR WITH TWO COLD GIANT PLANETS
Beaulieu, J.-P.,Bennett, D. P.,Batista, V.,Fukui, A.,Marquette, J.-B.,Brillant, S.,Cole, A. A.,Rogers, L. A.,Sumi, T.,Abe, F.,Bhattacharya, A.,Koshimoto, N.,Suzuki, D.,Tristram, P. J.,Han, C.,Gould, A American Astronomical Society 2016 The Astrophysical Journal Vol.824 No.2
<P>Two cold gas giant planets orbiting a G-type main-sequence star in the galactic disk were previously discovered in the high-magnification microlensing event OGLE-2012-BLG-0026. Here, we present revised host star flux measurements and a refined model for the two-planet system using additional light curve data. We performed high angular resolution adaptive optics imaging with the Keck and Subaru telescopes at two epochs while the source star was still amplified. We detected the lens flux, H = 16.39 +/- 0.08. The lens, a disk star, is brighter than predicted from the modeling in the original study. We revisited the light curve modeling using additional photometric data from the B&C telescope in New Zealand and CTIO 1.3 m H-band light curve. We then include the Keck and Subaru adaptive optic observation constraints. The system is composed of a similar to 4-9 Gyr lens star of M-lens = 1.06 +/- 0.05 M circle dot at a distance of D-lens = 4.0 +/- 0.3 kpc, orbited by two giant planets of 0.145 +/- 0.008 M-Jup and 0.86 +/- 0.06 M-Jup, with projected separations of 4.0 +/- 0.5 au and 4.8 +/- 0.7 au, respectively. Because the lens is brighter than the source star by 16 +/- 8% in H, with no other blend within one arcsec, it will be possible to estimate its metallicity using subsequent IR spectroscopy with 8-10 m class telescopes. By adding a constraint on the metallicity it will be possible to refine the age of the system.</P>
Mechanics of nanowire/nanotube in-surface buckling on elastomeric substrates
Xiao, J,Ryu, S Y,Huang, Y,Hwang, K-C,Paik, U,Rogers, J A IOP Pub 2010 Nanotechnology Vol.21 No.8
<P>A continuum mechanics theory is established for the in-surface buckling of one-dimensional nanomaterials on compliant substrates, such as silicon nanowires on elastomeric substrates observed in experiments. Simple analytical expressions are obtained for the buckling wavelength, amplitude and critical buckling strain in terms of the bending and tension stiffness of the nanomaterial and the substrate elastic properties. The analysis is applied to silicon nanowires, single-walled carbon nanotubes, multi-walled carbon nanotubes, and carbon nanotube bundles. For silicon nanowires, the measured buckling wavelength gives Young’s modulus to be 140 GPa, which agrees well with the prior experimental studies. It is shown that the energy for in-surface buckling is lower than that for normal (out-of-surface) buckling, and is therefore energetically favorable. </P>
Yoon, A-rum,Gao, Ran,Kaul, Zeenia,Choi, Il-Kyu,Ryu, Jihoon,Noble, Jane R.,Kato, Yoshio,Saito, Soichiro,Hirano, Takashi,Ishii, Tetsuro,Reddel, Roger R.,Yun, Chae-Ok,Kaul, Sunil C.,Wadhwa, Renu Oxford University Press 2011 Nucleic acids research Vol.39 No.18
<P>MicroRNAs (miRNAs) are a class of noncoding small RNAs that act as negative regulators of gene expression. To identify miRNAs that may regulate human cell immortalization and carcinogenesis, we performed comparative miRNA array profiling of human normal and SV40-T antigen immortalized cells. We found that miR-296 was upregulated in immortalized cells that also had activation of telomerase. By an independent experiment on genomic analysis of cancer cells we found that chromosome region (20q13.32), where miR-296 is located, was amplified in 28/36 cell lines, and most of these showed enriched miR-296 expression. Overexpression of miR-296 in human cancer cells, with and without telomerase activity, had no effect on their telomerase function. Instead, it suppressed p53 function that is frequently downregulated during human cell immortalization and carcinogenesis. By monitoring the activity of a luciferase reporter connected to p53 and p21<SUP>WAF1</SUP> (p21) untranslated regions (UTRs), we demonstrate that miR-296 interacts with the p21-3′UTR, and the Hu binding site of p21-3′UTR was identified as a potential miR-296 target site. We demonstrate for the first time that miR-296 is frequently upregulated during immortalization of human cells and contributes to carcinogenesis by downregulation of p53-p21<SUP>WAF1</SUP> pathway.</P>
R. Tremblay,C.A.Rogers 한국강구조학회 2005 International Journal of Steel Structures Vol.5 No.1
investigated. Several design strategies are examined including: design without a capacity based approach, capacity design withductile bracing components, and capacity design assuming the cold-formed steel roof diaphragm acts as the main energydisipation element in the seismic force resisting system. The effects of relaxing the period limitations and the capacity designforces for the roof diaphragm are also investigated. A building example is studied to illustrate the various design proceduresstrategies on the cost of the seismic force resisting systems. The building geometry, the seismic hazard level, the bracingconfiguration and the level of ductility are varied in this study. The results show that capacity design provisions have asignificant impact on the structure, especially when tension-compression bracing is used. Substantial savings could be realizedwith the use of a period obtained from methods of mechanics that incorporate diaphragm flexibility. Additional solutions fordiaphragm forces or selecting the diaphragm as the main energy disipating system.
Stretchable and Foldable Silicon Integrated Circuits
Kim, D.-H.,Ahn, J.-H.,Choi, W. M.,Kim, H.-S.,Kim, T.-H.,Song, J.,Huang, Y. Y.,Liu, Z.,Lu, C.,Rogers, J. A. American Association for the Advancement of Scienc 2008 Science Vol.320 No.5875
<P>We have developed a simple approach to high-performance, stretchable, and foldable integrated circuits. The systems integrate inorganic electronic materials, including aligned arrays of nanoribbons of single crystalline silicon, with ultrathin plastic and elastomeric substrates. The designs combine multilayer neutral mechanical plane layouts and 'wavy' structural configurations in silicon complementary logic gates, ring oscillators, and differential amplifiers. We performed three-dimensional analytical and computational modeling of the mechanics and the electronic behaviors of these integrated circuits. Collectively, the results represent routes to devices, such as personal health monitors and other biomedical devices, that require extreme mechanical deformations during installation/use and electronic properties approaching those of conventional systems built on brittle semiconductor wafers.</P>
Yeast Single-Cell Protein Production Using Potato Processing Waste Water
Park, Eung Yeal,Don L. Crawford,Roger A. Korus,Richard C. Heimsch 한국미생물 · 생명공학회 1991 Journal of microbiology and biotechnology Vol.1 No.3
Four species of yeast, Saccharomyces cerevisiae, Candida utilis, Saccharomycopsis fibuligera, and Schwanniomyces castellii were evaluated for their ability to bloconvert potato processing waste water into microbial protein and the resulting single-cell proteins were evaluated as protein sources for rainbow trout, using in vitro analyses. The studies indicated that Schwanniomyces castellii, which utilizes starch dircetly and converts it into cell mass efficiently, was suitable for the bioconversion. In the single-stage continuous bioconversion, the yield S. casteliii cell mass, which contained approximately 37% protein, was 77%, at dilution rate 0.25 h^-1. Reduction of total carbohydrate was 81%. During batch fermentations, cell mass yield was about 72% and total carbohydrate reduction was 81%. Among the yeasts tested, S. castellii possessed the most fragile cell wall and had a favorable amino acid profile for salmonid fish; protein score of 86% (Met). In an in vitro pepsin digestibility test 80% digestibility (23∼38% above control) was observed when cells were pre-heated in a steam bath for 30 min. Results presented should be regarded as being preliminary in nature because they were derived from single experiments.
Park, Min Soo,Rieger-Fackeldey, Esther,Schanbacher, Brandon L,Cook, Angela C,Bauer, John A,Rogers, Lynette K,Hansen, Thomas N,Welty, Stephen E,Smith, Charles V Williams & Wilkins Co.[etc.] 2007 Pediatric research Vol.62 No.6
<P>In the present study, we tested the hypothesis that exposure of newborn mice to sublethal hyperoxia would alter lung development and expressions of fibroblast growth factor receptors (FGFRs)-3 and FGFR-4. Newborn FVB mice were exposed to 85% O2 or maintained in room air for up to 14 d. No animal mortality was observed, and body weight gains were not affected by hyperoxia. At postnatal d 7 and 14 (P7, P14), lungs of mice exposed to 85% O2 showed fewer alveolar secondary crests and larger alveoli or terminal air spaces than did mice in room air. In pups kept in room air, lung levels of FGFR-3 and FGFR-4 mRNA were greater at P3 than at P1, but similar increases were not observed in hyperoxic mice. Immunoreactivity of FGFR-3 and FGFR-4 was lower in lungs of hyperoxic mice than in controls at P14. In pups kept in room air, lung fibroblast growth factor (FGF)-7 mRNA levels were greater at P14 than at P1, but similar changes were not observed in hyperoxic mice. The temporally and spatially specific alterations in the expressions of FGFR-3, FGFR-4, and FGF-7 in the mice exposed to hyperoxia may contribute to aberrant lung development.</P>
Cornichon Proteins Determine the Subunit Composition of Synaptic AMPA Receptors
Herring, Bruce E.,Shi, Y.,Suh, Y.,Zheng, C.Y.,Blankenship, Sabine M.,Roche, Katherine W.,Nicoll, Roger A. Cell Press 2013 Neuron Vol.77 No.6
Cornichon-2 and cornichon-3 (CNIH-2/-3) are AMPA receptor (AMPAR) binding proteins that promote receptor trafficking and markedly slow AMPAR deactivation in heterologous cells, but their role in neurons is unclear. Using CNIH-2 and CNIH-3 conditional knockout mice, we find a profound reduction of AMPAR synaptic transmission in the hippocampus. This deficit is due to the selective loss of surface GluA1-containing AMPARs (GluA1A2 heteromers), leaving a small residual pool of synaptic GluA2A3 heteromers. The kinetics of AMPARs in neurons lacking CNIH-2/-3 are faster than those in WT neurons due to the fast kinetics of GluA2A3 heteromers. The remarkably selective effect of CNIHs on the GluA1 subunit is probably mediated by TARP γ-8, which prevents a functional association of CNIHs with non-GluA1 subunits. These results point to a sophisticated interplay between CNIHs and γ-8 that dictates subunit-specific AMPAR trafficking and the strength and kinetics of synaptic AMPAR-mediated transmission.