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Review : What is the proper work-up of the patient with clinical early stage uterine adenocarcinoma
( Bruce Patsner ),( Matthew L Anderson ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.7
Objective: To discuss the proper preoperative workup of patients with uterine adenocarcinoma who present with disease clinically confined to the uterine corpus. Methods: Review of recommendations suggested in major textbooks in gynecologic oncology over the past thirty five years as well as select recent publications in the gynecologic oncology literature in Asia as well as the United States and Europe. Results: The suggested preoperative testing for the patient population under consideration has evolved over the years depending on whether the patient is at low risk or high risk for occult metastatic disease, Conclusion: Standard preoperative testing is always indicated but preoperative CA-125 and advanced radiological imaging are never routinely indicated for "low risk" patients. Either test may be indicated in select high-risk patients in the setting of clinical investigation though it is unclear which test, if either, provides enough meaningful clinical information which will either alter surgical management or which may be justified in light of the predicted high percentage of patients who will have normal preoperative test results.
Jacqueline M. E. Harrison,Leah M. Quanstrom,Alex R. Robinson,Bruce Wobeser,Stacy L. Anderson,Baljit Singh 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.1
Sepsis causes significant mortality in neonatal foals; however, there is little data describing the cellular and molecular pathways of lung inflammation in septic foals. This study was conducted to characterize lung inflammation in septic foals. Lung tissue sections from control (n = 6) and septic (n = 17) foals were compared using histology and immunohistology. Blinded pathologic scoring of hematoxylin and eosin stained samples revealed increased features of lung inflammation such as thickened alveolar septa and sequestered inflammatory cells in septic foals. Septic foal lungs showed increased expression of von Willebrand factor in blood vessels, demonstrating vascular inflammation. Use of MAC387 antibody to detect calprotectin as a reflection of mononuclear cell infiltration revealed a significant increase in their numbers in alveolar septa of lungs from septic foals compared to those from control foals. The mononuclear cells appeared to be mature macrophages and were located in the septal capillaries, suggesting they were pulmonary intravascular macrophages (PIMs). Finally, lungs from septic foals showed increased expression of Toll-like receptor 4 and 9 in mononuclear cells relative to the control. Taken together, this study is the first to show the expression of inflammatory molecules and an increase in PIMs in lungs from foals that died from sepsis.
An overview of mesoscale aerosol processes, comparisons, and validation studies from DRAGON networks
Holben, Brent N.,Kim, Jhoon,Sano, Itaru,Mukai, Sonoyo,Eck, Thomas F.,Giles, David M.,Schafer, Joel S.,Sinyuk, Aliaksandr,Slutsker, Ilya,Smirnov, Alexander,Sorokin, Mikhail,Anderson, Bruce E.,Che, Huiz Copernicus GmbH 2018 Atmospheric Chemistry and Physics Vol.18 No.2
<P>Abstract. Over the past 24 years, the AErosol RObotic NETwork (AERONET) program has provided highly accurate remote-sensing characterization of aerosol optical and physical properties for an increasingly extensive geographic distribution including all continents and many oceanic island and coastal sites. The measurements and retrievals from the AERONET global network have addressed satellite and model validation needs very well, but there have been challenges in making comparisons to similar parameters from in situ surface and airborne measurements. Additionally, with improved spatial and temporal satellite remote sensing of aerosols, there is a need for higher spatial-resolution ground-based remote-sensing networks. An effort to address these needs resulted in a number of field campaign networks called Distributed Regional Aerosol Gridded Observation Networks (DRAGONs) that were designed to provide a database for in situ and remote-sensing comparison and analysis of local to mesoscale variability in aerosol properties. This paper describes the DRAGON deployments that will continue to contribute to the growing body of research related to meso- and microscale aerosol features and processes. The research presented in this special issue illustrates the diversity of topics that has resulted from the application of data from these networks. </P>