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Neurodevelopment in Early Childhood Affected by Prenatal Lead Exposure and Iron Intake
Shah-Kulkarni, Surabhi,Ha, Mina,Kim, Byung-Mi,Kim, Eunjeong,Hong, Yun-Chul,Park, Hyesook,Kim, Yangho,Kim, Bung-Nyun,Chang, Namsoo,Oh, Se-Young,Kim, Young Ju,Lee, Boeun,Ha, Eun-Hee Wolters Kluwer Health 2016 Medicine Vol.95 No.4
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>No safe threshold level of lead exposure in children has been recognized. Also, the information on shielding effect of maternal dietary iron intake during pregnancy on the adverse effects of prenatal lead exposure on children's postnatal neurocognitive development is very limited. We examined the association of prenatal lead exposure and neurodevelopment in children at 6, 12, 24, and 36 months and the protective action of maternal dietary iron intake against the impact of lead exposure.</P><P>The study participants comprise 965 pregnant women and their subsequent offspring of the total participants enrolled in the Mothers and Children's environmental health study: a prospective birth cohort study. Generalized linear model and linear mixed model analysis were performed to analyze the effect of prenatal lead exposure and mother's dietary iron intake on children's cognitive development at 6, 12, 24, and 36 months.</P><P>Maternal late pregnancy lead was marginally associated with deficits in mental development index (MDI) of children at 6 months. Mothers having less than 75th percentile of dietary iron intake during pregnancy showed significant increase in the harmful effect of late pregnancy lead exposure on MDI at 6 months. Linear mixed model analyses showed the significant detrimental effect of prenatal lead exposure in late pregnancy on cognitive development up to 36 months in children of mothers having less dietary iron intake during pregnancy.</P><P>Thus, our findings imply importance to reduce prenatal lead exposure and have adequate iron intake for better neurodevelopment in children.</P></▼2>
Boeun Kim,Kangjae Yi,Sunyoung Jung,Seoyeon Ji,최민철,윤정희 대한수의학회 2014 JOURNAL OF VETERINARY SCIENCE Vol.15 No.3
Diffusion-weighted imaging (DWI) and apparent diffusioncoefficient (ADC) mapping are functional magneticresonance imaging techniques for detecting water diffusion. DWI and the ADC map were performed for intracraniallesions in two dogs. In necrotizing leukoencephalitis,cavitated lesions contained a hypointense center with ahyperintense periphery on DWI, and hyperintense signals onthe ADC maps. In metastatic sarcoma, masses including anecrotic region were hypointense with DWI, andhyperintense on the ADC map with hyperintense perilesionaledema on DWI and ADC map. Since DWI and ADC datareflect the altered water diffusion, they can provide additional information at the molecular level.
Boeun Kim,Hong Jang,Moon-Ho Eom,Jay H. Lee 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10
Biobutanol is considered to be a promising choice for renewable fuel due to its high energy content, low volatility, and low water solubility. However, the production of biobutanol through fermentation is complicated by the fact that butanol inhibits the microorganism’s cell growth and therefore the butanol production when its concentration in the fermentation broth reaches a certain critical level. In order to raise the volumetric productivity to a commercially acceptable level, produced biobutanol needs to be separated out as the fermentation is on-going. In this study, a continuous extractive fermentation process integrated with an ex-situ adsorption recovery process is studied to overcome this limitation. Switching of the adsorption column upon the saturation yields a continuous process with a cyclic steady state behavior. A dynamic model for the integrated process is developed and an optimization is performed based on the cyclic steady state analysis in order to design an optimal operation strategy that satisfies given requirements.
Multi-resolution Fusion Network for Human Pose Estimation in Low-resolution Images
Boeun Kim,YeonSeung Choo,Hea In Jeong,Chung-Il Kim,Saim Shin,김정호 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.7
2D human pose estimation still faces difficulty in low-resolution images. Most existing top-down approaches scale up the target human bonding box images to the large size and insert the scaled image into the network. Due to up-sampling, artifacts occur in the low-resolution target images, and the degraded images adversely affect the accurate estimation of the joint positions. To address this issue, we propose a multi-resolution input feature fusion network for human pose estimation. Specifically, the bounding box image of the target human is rescaled to multiple input images of various sizes, and the features extracted from the multiple images are fused in the network. Moreover, we introduce a guiding channel which induces the multi-resolution input features to alternatively affect the network according to the resolution of the target image. We conduct experiments on MS COCO dataset which is a representative dataset for 2D human pose estimation, where our method achieves superior performance compared to the strong baseline HRNet and the previous state-of-the-art methods.
Selective Monitoring and Imaging of Eosinophil Peroxidase Activity with a J-Aggregating Probe
Kim, Tae-Il,Hwang, Byunghee,Lee, Boeun,Bae, Jeehyeon,Kim, Youngmi American Chemical Society 2018 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.140 No.37
<P>The specific detection of eosinophil peroxidase (EPO) activity requires the difficult distinction between hypobromous acid generated by EPO and hypochlorous acid generated by other haloperoxidases. Here we report a fluorogenic probe that is halogenated with high kinetic selectivity (≥1200:1) for HOBr over HOCl. Heavy-atom effects do not quench the dibrominated product because of its self-assembly into emissive J-aggregates that provide a turn-on signal. Applications of this fluorogen to EPO activity assays, dipstick sensors, fluorescence imaging of EPO activity, assays of oxidative stress in cancer cells, and immune response detection in live mice are reported.</P> [FIG OMISSION]</BR>