A REMARK ON CONVERGENCE THEORY FOR ITERATIVE PROCESSES OF PROINOV CONTRACTION

Bisht, Ravindra K. Korean Mathematical Society 2019 대한수학회논문집 Vol.34 No.4

In this paper, we extend the study of general convergence theorems for the Picard iteration of Proinov contraction from the class of continuous mappings to the class of discontinuous mappings. As a by product we provide a new affirmative answer to the open problem posed in [20].

Mycobacterial formulation in liposomes showed decreasedexpression of CD95/CD95L and caspase activity in T cellsof leprosy patients

Vandana Bisht,Vineeta Chattree,,Neena Khanna,,D.N. Rao 한국물리학회 2005 Current Applied Physics Vol.5 No.2

Leprosy, a debilitating disease shows manifestations ranging from strong cell mediated immune (CMI) response in tuberculoidform (BT/TT) or weak CMI with immunological anergy in lepromatous form (BL/LL). Repeated stimulation with mycobacterialantigen causes activation induced cell death (apoptosis) or anergy in these patients. Previous studies showed in vitro T cell prolif-eration and increased Th1 response with liposomal (particulate) presentation of mycobacterial antigens with immunomodulators(MDP analog, murabutide and T cell peptide of Trat protein). In the present study, the role of caspases; expression of apoptoticmarkers, CD95 and CD95L in T cells of leprosy patients and the eect of particulate formulations in the reversal of apoptosisin BT/TT and BL/LL patient group was studied. Caspase 8/3 activity was maximum (p<0.01) in BL/LL patients in constitutivestate, which was followed by decreased activity in BT/TT and normal subjects. Caspase 8/3 activity increased signicantly(p<0.05) from constitutive state after 5 days of antigen stimulation (inducible state). Both the antigens were equally potent in induc-ing the apoptosis in leprosy patients. A decreased caspase activity using the particulate formulations of both antigens was observedin BL/LL group. The expression of CD95 and CD95L in T cells of leprosy patients increased signicantly after 5 days of antigenstimulation. However, % expression of apoptotic markers by T cells of BL/LL patients decreased signicantly (p<0.05) when theparticulate formulations were used. To summarize, the particulate formulations of antigens with immunomodulators slowed downthe apoptosis and hence T cell anergy in leprosy by stimulating the cells to proliferate..

Various Techniques to Reduce PAPR in OFDM Systems : A Survey

Mamta Bisht,Alok Joshi 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.11

A non-constant envelope with high peaks is a main disadvantage of Orthogonal Frequency Division Multiplexing (OFDM). These high peaks produce signal excursions into non-linear region of operation of the Power Amplifier (PA) at the transmitter, thereby leading to non-linear distortions and spectral spreading. Many Peak to Average Power Ration (PAPR) reductions methods have been proposed in the literature. The objective of this review is to give a clear understanding of different techniques to reduce PAPR of the signal.

Reliability analysis of acyclic transmission network based on minimal cuts using copula in repair

Soni Bisht,S.B Singh 장전수학회 2019 Proceedings of the Jangjeon mathematical society Vol.22 No.1

In the present paper, we have considered acyclic transmission network in which number of nodes are capable of receiving or sending a signal to the target nodes. To model the proposed acyclic transmission network, the present study combined the concepts of Markov process and minimal cuts incorporating copula to find the various reliability measures. The considered network can have four possible states namely operable, partial failure, critical failure and complete failure. The considered network can be repaired in two different ways. When the network is in critical state it is repaired with general repair whereas in complete failure state repaired with the help of two different repair rates namely general and exponential which has been incorporated with the application of Gumbel-Hougaard family of copula. Various reliability characteristics such as transition state probabilities, asymptotic behavior, reliability, mean time to failure and sensitivity of the proposed network have been evaluated with the help of minimal cuts coupling with Markov process using Gumbel-Hougaard copula, supplementary variable technique and Laplace transforms.

In vivo Acute Cytotoxicity Study of Poly(2-amino ethyl methacrylateco- methylene bis-acrylamide) Magnetic Composite Synthesized in Supercritical CO2

Gunjan Bisht,M. G. H. Zaidi,Biplab KC 한국고분자학회 2018 Macromolecular Research Vol.26 No.7

With magnetic ferrite nanoparticles (FNPs) gaining interest in biotechnological fields and methacrylates being used as synthetic polymer for therapeutics loading and conjugation, we attempt to make novel magnetic composite by supercritical CO2 assisted entrapment of FNPs into in situ synthesized polymeric mesh of 2-amino ethyl methacrylate (AEMA) cross linked with methylene bis-acrylamide (MBA) at90±1 oC and pressure of 1200 psivia 2,2-azobisisobutyronitrile (AIBN) initiated radical polymerization. Particle thus obtained was characterized by using proton nuclear magnetic resonance (1H NMR), X-ray diffraction (XRD), thermal gravimetric-derivative thermogravimetric-differential thermal analysis (TG-DTGDTA), atomic force microscopy (AFM), and vibrating sample magnetometer (VSM). 1H NMR of Copolymer (without FNPs embedded) demonstrated distinct peaks verifying AEMA moieties flanked by MBA moieties with free amino group. Though the particle showed less saturation magnetization than that of as synthesized FNPs, it still maintained similar magnetic profile. AFM results showed average grain size of polymeric magnetic composites (PMCs) to be 80 nm with less agglomeration. TGA results verify the thermal stability of the compound upto 200 oC. In vivo acute cytotoxicity was profiled by administrating four different concentrations of FNPs, Copolymer and PMCs (FNPs embedded) into Sprague Dawley albino rat intraperitonally for 14 days and measuring various hematological, biochemical and serum enzymatic parameters along with histological examinations. Overall, PMCs showed no significance change in these parameters compared to normal saline administered control which signifies biocompatible nature of the composite. Hence, clean synthesis of FNPs embedded biocompatible amino functional magnetic composite has been achieved which holds potential in number of applications like drug loading, enzyme immobilizations, targeted therapy, etc.

From papyrus leaves to bioprinting and virtual reality: history and innovation in anatomy

Bharti Bisht,Ashley Hope,Manash K. Paul 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.3

The human quest to master the anatomy and physiology of living systems started as early as 1600 BC, with documents from the Greeks, Indians, and Romans presenting the earliest systematic studies and advances. Following the fall of the Roman Empire, the progress slowed until the Renaissance renewed scientific interest in anatomy and physiology, ushering in an era of spectacular advances. Alongside the discoveries of modern science, innovations in media such as printing, photography and color reproduction, improved the accuracy of communicating science. Techniques for noninvasively viewing the human body, such as magnetic resonance imaging, opened up new ways of exploring and understanding anatomy, physiology, and disease pathogenesis. Advances in three-dimensional (3D)-technologies, including computer graphics and animation are directly linked to many advances in medicine and surgery. Anatomy education has come a long way from papyrus leaf inscriptions to computerized 3D modeling, holographic representation, and virtual reality-based software. The future presents unlimited options for studying and understanding anatomy as Google glasses, bioprinting, virtual reality, and allied technologies transform the world into a classroom. This review summarizes the journey of mankind to master anatomy and physiology.

Nature goes wild, where humans lost their pride

Shubham Bisht Bharat Singh Bis 한국색채학회 2020 International Invitation Exhibition of Color Works Vol.- No.-

Reliability analysis of acyclic transmission network based on minimal cuts using copula in repair

Soni Bisht,S.B Singh 장전수학회 2019 Proceedings of the Jangjeon mathematical society Vol.22 No.3

In the present paper, we have considered acyclic transmis- sion network in which number of nodes are capable of receiving or send- ing a signal to the target nodes. To model the proposed acyclic trans- mission network, the present study combined the concepts of Markov processes and minimal cuts incorporating copula to nd the various re- liability measures. The considered network can have four possible states namely operable, partial failure, critical failure and complete failure. The proposed network can be repaired in two dierent ways. When the network is in critical state it is repaired with general repair, whereas, in complete failure state it is repaired with the help of two dierent repair rates, namely, general and exponential. The general and expo- nential distributions have been incorporated with the application of the Gumbel-Hougaard family of copula. Various reliability characteristics such as transition state probabilities, asymptotic behavior, reliability, mean time to failure and sensitivity of the proposed network has been evaluated with the help of minimal cuts coupling with Markov processes using GumbelHougaard copula, supplementary variable techniques and Laplace transforms.

Old Age

Shubham Bisht BHARAT SINGH BIS 한국색채학회 2019 International Invitation Exhibition of Color Works Vol.- No.-

Phytochemistry and pharmacological activity of the genus artemisia

Dheeraj Bisht,Deepak Kumar,Dharmendra Kumar,Kamal Dua,Dinesh Kumar Chellappan 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.5

Artemisia and its allied species have beenemployed for conventional medicine in the Northern temperateregions of North America, Europe, and Asia for thetreatments of digestive problems, morning sickness, irregularmenstrual cycle, typhoid, epilepsy, renal problems, bronchitismalaria, etc. The multidisciplinary use of artemisiaspecies has various other health benefi ts that are related toits traditional and modern pharmaceutical perspectives. Themain objective of this review is to evaluate the traditional,modern, biological as well as pharmacological use of theessential oil and herbal extracts of Artemisia nilagirica,Artemisia parvifl ora, and other allied species of Artemisia. It also discusses the botanical circulation and its phytochemicalconstituents viz disaccharides, polysaccharides,glycosides, saponins, terpenoids, flavonoids, and carotenoids. The plants have diff erent biological importance likeantiparasitic, antimalarial, antihyperlipidemic, antiasthmatic, antiepileptic, antitubercular, antihypertensive, antidiabetic,anxiolytic, antiemetic, antidepressant, anticancer, hepatoprotective,gastroprotective, insecticidal, antiviral activities, andalso against COVID-19. Toxicological studies showed thatthe plants at a low dose and short duration are non or lowtoxic. In contrast, a high dose at 3 g/kg and for a longer durationcan cause toxicity like rapid respiration, neurotoxicity,reproductive toxicity , etc. However, further in-depth studiesare needed to determine the medicinal uses, clinical effi cacyand safety are crucial next steps.