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글루타메이트로 유도된 쥐 해마 HT22 세포의 산화적 손상에 대한 서양민들레 지상부의 뇌신경세포 보호활성
리빈,이동성,최현규,김경수,지혜영,노정미,김기모,김윤철,Li, Bin,Lee, Dong-Sung,Choi, Hyun-Gyu,Kim, Kyung-Su,Ji, Hye-Young,Rho, Jung-Mi,Kim, Ki-Mo,Kim, Youn-Chul 대한약학회 2011 약학회지 Vol.55 No.4
Glutamate-induced oxidative injury contributes to neuronal degeneration in many central nervous system (CNS) diseases, such as epilepsy and ischemia. Inducible heme oxygenase (HO)-1 acts against oxidants that are thought to play a role in the pathogenesis of these diseases. In the present study, we investigated the neuroprotective effects of the standard extracts of Taraxacum officinale Weber, one of the original plants of Taraxaci Herba, on glutamate-induced oxidative injury in mouse hippocampal HT22 cells. The standard EtOH extract of the aerial parts of T. officinale (NNMBS270) showed significant cytoprotective effects on glutamate-induced neurotoxicity and induced the expression of heme oxygenase (HO)-1 in the mouse hippocampal HT22 cells, while the roots' extract (NNMBS271) did not show neuroprotective effect. These results suggest that the extract of the aerial parts of T. officinale could be an effective candidate for the treatment of ROS-related neurological diseases.
사백산 물 추출물과 30% EtOH 추출물의 항염증 효과 비교연구
이동성(Dong-Sung Lee),최현규(Hyun-Gyu Choi),김경수(Kyoung-Su Kim),김동철(Dong-Cheol Kim),민홍기(Hong-Ki Min),리빈(Bin Li),김종수(Jong-Su Kim),박준형(Jun-Hyeong Park),오현철(Hyuncheol Oh),김윤철(Youn-Chul Kim) 대한약학회 2012 약학회지 Vol.56 No.4
Sabaek-san has been used for the treatment of inflammatory diseases derived from the cold with high fever, cough, and lung dysfunction in Korea and China. There is no study for the comparison between different solvent extracts of Sabaek-san. We made two samples, one is Sabaek-san water extract (SBSW) and the other is Sabaek-san 30% EtOH extract (SBSE). Both extracts inhibited inducible nitric oxide synthase(iNOS) protein, reduced iNOS-derived nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Also, they reduced tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) production. These anti-inflammatory effects caused by induction of heme oxygenase (HO)-1. HO-1 enzyme plays an important role of cellular anti-oxidant and anti-inflammatory systems. The induction of HO-1 is primarily regulated at the transcriptional level, and its induction by various inducers is related to the nuclear transcription factor-E2-related factor 2 (Nrf2). However, it is worth taking note that SBSE has more powerful anti-inflammatory effects than SBSW. In this study we suggest that different solvent extraction makes different therapeutic actions.