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( Sanjeev Kumar Maurya ),( Mallika Tewari ),( Bechan Sharma ),( Hari Shanker Shukla ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.5
Background/Aims: The higher incidence of gallbladder cancer (GBC) in females has been accredited to the involvement of hormones. The clinical implications of sex hormone receptors in GBC are well established. Cysteine proteases (such as caspase-3-9, etc.) are known to play a central role in the apoptotic pathway. Of these, the downstream enzyme caspase-3 is often activated in the apoptotic pathway. The aim of this work was to examine the status of apoptosis (which directly correlated with the level of active caspase-3) in hormone-responsive GBC. Methods: We used 10 androgen receptor (AR)-positive, 14 estrogen receptor (ER)-positive, 12 HER/neu-positive, eight triple positive, and 10 triple negative malignant GBC human tissue samples. We isolated the total cellular protein from tumor tissues and carried out Western blotting using antipro-caspase-3 and anti-activated caspase-3 antibodies. Results: ER and HER/neu-positive GBC exhibited high caspase-3 activity and low procaspase-3 activity, whereas AR-positive GBC showed no significant level of apoptosis. We also evaluated the apoptosis status of triple positive GBC and triple negative GBC, and found significant apoptosis in triple positive GBC. Conclusions: The results indicate that ER and HER/neu-positive GBCs had active apoptosis, whereas AR-positive GBC was highly resistant to apoptosis.
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Current Scenario of Legume Lectins and Their Practical Applications
Ajay Kumar Gautam,Nidhi Shrivastava,Bechan Sharma,Sameer. S. Bhagyawant 한국작물학회 2018 Journal of crop science and biotechnology Vol.21 No.3
Lectins are diverse group of carbohydrate binding proteins distributed ubiquitously in plant species. Lectins are the subject of intense investigation. Therefore, in the past few years studies on legume lectins with respect to their biochemical and pharmacological properties have been extensively carried out. Legume lectins are reported to contain antifungal, mitogenic, immunomodulatory, and antitumor properties. Some of the lectin also display anti-HIV-1 reverse transcriptase and antineoplastic activities. Plant lectins are expected to open new vistas for the design and development of drugs to be used against different serious diseases. This article aims to review up-to-date advances of legume lectins vis-à-vis structure, biological properties, and their practical applications.
KCI
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