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Kim, Ba Reum,Ha, Jain,Kang, Eunjeong,Cho, Sayeon Korean Society for Biochemistry and Molecular Biol 2020 BMB Reports Vol.53 No.6
Since cancer is the leading cause of death worldwide, there is an urgent need to understand the mechanisms underlying cancer progression and the development of cancer inhibitors. Signal transducer and activator of transcription 3 (STAT3) is a major transcription factor that regulates the proliferation and survival of various cancer cells. Here, dual-specificity phosphatase 3 (DUSP3) was identified as a regulator of STAT3 based on an interaction screening performed using the protein tyrosine phosphatase library. DUSP3 interacted with the C-terminal domain of STAT3 and dephosphorylated p-Y705 of STAT3. In vitro dephosphorylation assay revealed that DUSP3 directly dephosphorylated p-STAT3. The suppressive effects of DUSP3 on STAT3 were evaluated by a decreased STAT3-specific promoter activity, which in turn reduced the expression of the downstream target genes of STAT3. In summary, DUSP3 downregulated the transcriptional activity of STAT3 via dephosphorylation at Y705 and also suppressed the migratory activity of cancer cells. This study demonstrated that DUSP3 inhibits interleukin 6 (IL-6)/STAT3 signaling and is expected to regulate cancer development. Novel functions of DUSP3 discovered in IL-6/STAT3 signaling regulation would help expand the understanding of cancer development mechanisms.
( Ba Reum Kim ),( Young-chang Cho ),( Sayeon Cho ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.6
Small-molecule inhibitors are widely used to treat a variety of inflammatory diseases. In this study, we found a novel antiinflammatory compound, 1-[(2R,4S)-2-methyl-4-(phenylamino)-1,2,3,4-tetrahydroquinolin-1-yl]prop-2-en-1-one (MPQP). It showed strong anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. These effects were exerted through the inhibition of the production of NO and pro-inflammatory cytokines, such as interleukin (IL)-6, IL-1β, and tumor necrosis factor-α (TNF-α). Furthermore, MPQP decreased the expression levels of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2). Additionally, it mediated the inhibition of the phosphorylation of p38, c-Jun N-terminal kinase (JNK), the inhibitor of κBα (IκBα), and their upstream kinases, IκB kinase (IKK) α/β, mitogen-activated protein kinase kinase (MKK) 3/6, and MKK4. Furthermore, the expression of IL-1 receptor-associated kinase 1 (IRAK1) that regulates NF-κB, p38, and the JNK signaling pathways, was also increased by MPQP. These results indicate that MPQP regulates the IRAK1-mediated inflammatory signaling pathways by targeting IRAK1 or its upstream factors. [BMB Reports 2018; 51(6): 308-313]
고압 다이캐스팅법으로 제조한 편상흑연주철-알루미늄 이종소재의 계면접합특성에 미치는 탈흑연 열처리의 영향
양지바름 ( Ji-ba-reum Yang ),김태형 ( Taehyeong Kim ),정재헌 ( Jaeheon Jeong ),김상우 ( Sangwoo Kim ),김윤준 ( Yoonjun Kim ),김동응 ( Dongeung Kim ),신제식 ( Jesik Shin ) 한국주조공학회 2021 한국주조공학회지 Vol.41 No.6
본 연구에서는 주철-알루미늄 이종재료의 계면결합강도를 향상시키기 위하여 탈흑연 열처리를 통해 주철 표면에서 일정 깊이까지의 흑연을 제거하였다. 열처리 시간이 증가함에 따라 흑연이 제거되는 깊이는 증가하였으며, 열처리 시간과 깊이 사이에 선형 관계가 나타났다. 일정 깊이의 흑연이 제거된 주철에 알루미늄을 다이캐스팅 공법으로 주조접합하여 주철에서 흑연이 제거된 공간을 알루미늄으로 채운 후, 계면 반응 및 알루미늄 침투 깊이를 조사하고 계면접합강도를 평가하였다. 다이캐스팅 공법을 통한 알루미늄은 탈흑연 열처리된 주철 표면에서 일정한 깊이까지 채워지는 것으로 확인되었으며, 주철-알루미늄 계면에 금속간화합물이 생성되지는 않은 것으로 확인되었다. 계면접합강도는 열처리 시간과는 큰 관계없이 90MPa 수준의 접합강도를 나타내었으며 이는 탈흑연열처리를 하지 않은 소재의 접합강도 12MPa에 비해 매우 높은 강도이며, 주철의 탈흑연 영역에서 고압 다이캐스팅 공정에 의해 침투된 알루미늄 용탕이 응고되면서 언더컷 구조의 기계적 결합에 의한 것으로 생각된다. In this study, to improve the interfacial bond strength of cast iron-aluminum dissimilar materials, graphite was removed to a certain depth from the cast iron surface through de-graphitization heat treatment. As the heat treatment time increased, the depth at which graphite was removed increased, showing a linear relationship between the heat treatment time and depth. Aluminum was filled to a certain depth on the de-graphitized cast iron surface through die-casting method, and no intermetallic compounds were formed on the cast iron-aluminum interface. The interfacial bonding strength showed a value of 90 MPa regardless of the heat treatment time, which is very high compared to the 12MPa bonding strength of the material without de-graphitization heat treatment. This result is thought to be due to the mechanical bonding of the undercut structure as the liquid aluminum, penetrated by the high pressure die-casting process, solidified in the de-graphitized region of the cast iron.
위성 Link-K를 위한 비동기식 수신기 시뮬레이터 설계
김미선(Kim Mi Sun),오지혜(Oh Ji Hye),이바름(Lee Ba Reum),정은경(Jung Eun Kyung),유정화(Yoo Jung Hwa),Nazcar Pine,최상호(Choe Sangho) 한국통신학회 2010 한국통신학회 학술대회논문집 Vol.2010 No.11
본 논문은 한국형 전술 데이터링크인 위성 Link-K(기본형)를 위한 비동기식 수신기 시뮬레이터를 Matlab Simululink를 이용하여 설계한다. 전술용 데이터링크 채널모델로는 표준모델인 two-ray Rician Doppler fading을 채택한다. DBPSK, DQPSK, D8PSK의 비동기식 변복조기, Early-Late게이트의 심볼동기 모듈, Raised Cosine 필터, 지연 및 Doppler를 갖는 다중경로 페이딩 채널 모듈 등을 Simulink로 구현하고 지상용과 공중환경 등 서로 다른 전술운용환경 하에서 성능을 비교한다.
위성 Link-K를 위한 비동기식 수신기 시뮬레이터 설계
김미선(Kim Mi Sun),오지혜(Oh Ji Hye),이바름(Lee Ba Reum),정은경(Jung Eun Kyung),유정화(Yoo Jung Hwa),Nazcar Pine,최상호(Choe Sangho) 대한전자공학회 2010 대한전자공학회 학술대회 Vol.2010 No.10
본 논문은 한국형 전술 데이터링크인 위성 Link- K(기본형)를 위한 비동기식 수신기 시뮬레이터를 Matlab Simululink를 이용하여 설계한다. 전술용 데이터링크 채널모델로는 표준모델인 two-ray Rician Doppler fading을 채택한다. DBPSK, DQPSK의 비동기식 변복조기, Early-Late게이트의 심볼동기 모듈, Raised Cosine 필터, 지연 및 Doppler를 갖는 다중경로 페이딩 채널 모듈을 Simulink로 구현하고 지상용과 공중환경 등 서로 다른 전술운용환경 하에서 성능을 비교한다.
오아름 ( A-reum Oh ),고바라다 ( Ba-ra-da Koh ),정보람 ( Bo-ram Jung ),나호명 ( Ho-myoung Na ),배성열 ( Seong-yeol Bae ),김용환 ( Yong-hwan Kim ) 한국동물위생학회(구 한국가축위생학회) 2021 韓國家畜衛生學會誌 Vol.44 No.1
Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Domestic ruminants are considered to be major source of human infection. The aim of this survey was to investigate seroprevalence of C. burnetii in ruminants in Gwangju area. A total of 1,000 samples (serum and lactoserum) were collected from 987 Korean native cattle, 5 Korean native goats, 2 beef cattle, 6 bulk-tank milk from each dairy farm in Gwangju area from January to October 2020 and analyzed by ELISA. The seroprevalence of C. burnetii in bulk-tank milk from each dairy farms was 50.0%. Korean black goat and beef cattle had negative antibody test results for C. burnetii. The seroprevalence of C. burnetii in Korean native cattle in Gwangju area was 7.1% and was higher in female (7.8%) than in male (3.4%) (P=0.024). The seroprevalence of C. burnetii in Korean native cattle appeared to increase with age (3.8% in 1 year-old, 7.1% in 3 year-old, and 10.7% in more than 5 year-old) (P<0.001). The seroprevalence of C. burnetii of Korean native cattle increased in spring and May was the highest in particular (P<0.001). As the distribution and density of tick-habitat are expected to increase due to climate crisis, this survey highlights the need for monitoring C. burnetii in domestic ruminants, including surveillance of C. burnetii infection in people working for livestock industry.
Jae Young Lee,Ba-Reum Kim,Hyun In Oh,Lingai Shen,Naeung Bae Kim,Jae-Kwan Hwang 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.6
Peroxisome proliferator-activated receptor-gamma (PPARγ), a member of the nuclear receptor of ligand-activated transcription factors, plays a key role in lipid and glucose metabolism or adipocytes differentiation. A lignan compound was isolated from mace (the aril of Myristica fragrans Houtt.) as a PPARγ ligand, which was identified as fragrin A or 2-(4-allyl-2,6-dimethoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)-propane. To ascertain whether fragrin A has PPARγ ligand-binding activity, it was performed that GAL-4/PPARγ transactivation assay. PPARγ ligand-binding activity of fragrin A increased 4.7, 6.6, and 7.3-fold at 3, 5, and 10 μM, respectively, when compared with a vehicle control. Fragrin A also enhanced adipocytes differentiation and increased the expression of PPARγ target genes such as adipocytes fatty acid-binding protein (aP2), lipoprotein lipase (LPL), and phosphoenol pyruvate carboxykinase (PEPCK). Furthermore, it significantly increased the expression level of glucose transporter 4 (GLUT4). These results indicate that fragrin A can be developed as a PPARγ agonist for the improvement of insulin resistance associated with type 2 diabetes.