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        • A Cyclin D1 (CCND1) Gene Polymorphism Contributes to Susceptibility to Papillary Thyroid Cancer in the Turkish Population

          Aytekin,,Turkan,Aytekin,,Alper,Maralcan,,Gokturk,Gokalp,,M.,Avni,Ozen,,Dogukan,Borazan,,Ersin,Yilmaz,,Latif Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

          Cyclin D1 is an important positive regulator of the G1/S phase of the cell cycle. We investigated the association between the CCND1 G870A polymorphism and susceptibility to papillary thyroid cancer in Turkish people. This study covered 102 patients with papillary thyroid cancer and 174 healthy controls. CCND1 genotyping was determined by the PCR-RFLP method. We found that the A allele frequency was higher in the cases than in the controls (p=0.042). On stratification analysis, papillary thyroid cancer risk was significantly elevated in individuals older than 45 years with the A allele (OR=1.91, 95% CI, 1.09-3.35, p=0.024) and in females with the A allele (OR=1.73, 95% CI, 1.06-2.84, p=0.029), compared to the G allele. According to the subject age, there was an increased papillary thyroid cancer risk for the individuals older than 45 years with the AA genotype (OR=2.28, 95% CI, 1.02-5.13, p=0.046) compared to the AG+GG combined genotypes. In conclusion, it is suggested that the CCND1 G870A polymorphism may contribute to the susceptibility to papillary thyroid cancer, especially in those who were older subjects ($45{\leq}$ years old) and female, in the Turkish population.

        • Polycystic Ovary Syndrome and Risk of Endometrial Cancer: a Mini-Review

          Tokmak,,Aytekin,Kokanali,,Mahmut,Kuntay,Guzel,,Ali,Irfan,Kara,,Aydan,Topcu,,Hasan,Onur,Cavkaytar,,Sabri Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

          The polycystic ovary syndrome is the most common endocrinological disorder of reproductive age women with a prevalence of 5 to 8 %. The most common diagnostic criteria used for polycystic ovary syndrome are oligo- or an-ovulation, clinical and/ or biochemical signs of hyperandrogenism and polycystic ovaries. Hyperandrogenism results in increased estrogen levels and lack of cyclic progesterone due to anovulation and persistent stimulation of the endometrium may lead to endometrial hyperplasia or adenocarcinoma development. In this mini review, we aimed to evaluate the possible relationship between polycystic ovary syndrome and endometrial cancer.

        • KCI등재SCIESCOPUS

          An Investigation of the Nuclear Properties of 24O, 30Si, 30S, 54Ca, and 96Zr New Magic Nuclei

          H.,Aytekin 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.12

          In this study, the binding energies per particle, the two-neutron and two-proton separation energies and the average proton-neutron interaction strengths of the new magic <sup>24</sup>O, <sup>30</sup>Si, <sup>30</sup>S, <sup>54</sup>Ca, and <sup>96</sup>Zr nuclei are investigated by using the Hartree-Fock-Bogoliubov (HFB) method with SKM<sup>*</sup>, SLy4, SLy5, and SIII Skyrme-like forces. The calculated results are compared with the experimental data and with the results obtained using the relativistic mean field theory (RMFT).

        • Clinical Significance of Atypical Squamous Cells of Undetermined Significance in Detecting Preinvasive Cervical Lesions in Post-Menopausal Turkish Women

          Tokmak,,Aytekin,Guzel,,Ali,Irfan,Ozgu,,Emre,Oz,,Murat,Akbay,,Serap,Erkaya,,Salim,Gungor,,Tayfun Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

          Background: To evaluate the clinical significance of atypical squamous cells of undetermined significance (ASCUS) in PAP test in post-menopausal women and compare with reproductive age women. Materials and Methods: A total of 367 patients who referred to our gynecologic oncology clinic were included to the study between September 2012 and August 2013. Data for 164 post-menopausal (group 1) and 203 pre-menopausal (group 2) women with ASCUS cytology were evaluated retrospectively. Immediate colposcopy and endocervical curettage was performed for both groups and conization for all women with a result suggestive of CIN2-3. Histopathological results and demographic features of patients were compared between the two groups. Results: Mean age of the patients was $54.6{\pm}6.5$ years in group 1 and $38{\pm}6.6$ years in group 2. Some 14 (8.5%) of post-menopausal women and 36 (17.7%) of pre-menopausal women were current smokers (p=011). Totals of 38 (23.2%) post-menopausal and 64 (31.5%) pre-menopausal women were assessed for HPV-DNA. High risk HPV was detected in 7 (4.3%) and 21 (10.3%), respectively (p=0.029). Final histopathological results recorded were normal cervix, low grade cervical intra-epithelial neoplasia (CIN 1), and high grade cervical intra-epithelial neoplasia (CIN2-3). In group 1 results were 84.8%, 12.2% and 1.8%, respectively, and in group 2 were 71.9%, 23.2% and 4.9%. There were no cases of micro invasive or invasive cervical carcinoma in either group. Two cases were detected as endometrial carcinoma in the menopausal group (1.2%). Conclusions: In current study we found that preinvasive lesions were statistically significantly higher in pre-menopausal women than post-menopausal women with ASCUS. Cervicitis was more common in menopausal women. Therefore, we think that in case of ASCUS in a post-menopausal woman there is no need for radical management.

        • Increased UGT1A3 and UGT1A7 Expression is Associated with Pancreatic Cancer

          Yilmaz,,Latif,Borazan,,Ersin,Aytekin,,Turkan,Baskonus,,Ilyas,Aytekin,,Alper,Oztuzcu,,Serdar,Bozdag,,Zehra,Balik,,Ahmet Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4

          UGT1A play important roles in the glucuronidation of a variety of endogenous and exogenous compounds. UGT1A isoforms are expressed tissue specifically. The aim of this study was to examine the relationship between UGT1A3 and UGT1A7 mRNA expression and pancreatic cancer. Paired healthy and tumor tissue samples of 43 patients with pancreatic cancer were included in this study. UGT1A3 and UGT1A7 mRNA expressions were analyzed by real time-PCR. In the result of study, UGT1A3 and UGT1A7 mRNA expressions were significantly higher in tumor tissue than normal tissue of pancreatic cancer patients (p<0.05). In addition, high mRNA expression of UGT1A3 and UGT1A7 was significantly associated with larger tumor size (p<0.05). The data suggested that UGT1A3 and UGT1A7 may play roles in the progression of pancreatic cancer. Consequently, UGT1A3 and UGT1A7 are potential prognostic indicators.

        • KCI등재

          The statistical optimization of bacterial cellulose production via semi-continuous operation mode

          Ali,,zhan,Aytekin,Deniz,Dilan,Demirbag,Tug˘c¸e,Bayrakdar 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.37 No.-

          Bacterial cellulose (BC) is highly pure and has a higher crystallinity and molecular weight than plantcellulose. Therefore, BC can be used in many different areas such as biotechnology, pharmaceutical,cosmetics. Because of the price of BC, the productivity of BC is an important parameter for industrial scaleapplications. In this study, BC was produced in static culture using a semi-continuous operation mode;the conditions were optimized using response surface methodology (RSM). The collected BC wascharacterized by Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM),and tensile strength. Optimization parameters were selected as glucose concentration, surface area/volume ratio, surface area and incubation day intervals. The optimum values for incubation dayintervals, volume changing ratios, glucose concentrations and surface area/volume ratios were 7 days,66%, 50 g/L and 1.22 cm 1, respectively. BC productivity reached 0.284 g/L/day under optimalconditions, while the model equation proposed 0.289 g/L/day. RSM is essential for determining theoptimum values of parameters for BC production compared with the one-variable-at-a-time method. The semi-continuous operation mode is alternative and a good candidate for the industrial scaleproduction of BC.

        • KCI등재SCOPUS

          Asymmetrical Dimethylarginine Levels in Hepatitis B Virus-Positive Patients

          Faruk,Karakecili,Aytekin,Cikman,Merve,Aydin,Baris,Gulhan 대한진단검사의학회 2018 Annals of Laboratory Medicine Vol.38 No.5

          Background: High asymmetrical dimethylarginine (ADMA) levels have been associated with endothelial dysfunction and contribute to the development of several diseases. However, data on the relationship between hepatitis B virus (HBV) and ADMA are limited. The aim of our study was to explore the relationship between ADMA and HBV by comparing the ADMA levels in patients with chronic active hepatitis B (CHB), inactive HBV carriers (carriers), and healthy volunteers (controls). Methods: The participants were divided into three groups: 90 patients with CHB, 90 HBV carriers, and 90 controls. Serum ADMA levels were quantified using an ELISA kit (Cusabio, Wuhan, China). The data were analyzed using an ANOVA or the Kruskal-Wallis test as appropriate, with P<0.05 considered significant. Results: Serum ADMA levels were significantly higher in patients with CHB (228.35±91.10 ng/mL) than in HBV carriers (207.80±75.80 ng/mL) and controls (207.61±89.10 ng/mL) (P=0.049). The clinical scores of the patients were positively correlated with ADMA levels. Conclusions: The elevated serum ADMA levels in patients with CHB confirm that HBV plays a role in vasculitis. Further investigation of the mechanisms contributing to the high levels of ADMA in CHB may contribute toward development of new treatment modalities

        • KCI등재SCOPUS

          Predicting Intermittent Atrial Fibrillation in Outpatient Clinics

          Mustafa,Karaca,Deniz,Aytekin 대한심장학회 2017 Korean Circulation Journal Vol.47 No.3

          Background and Objectives: Palpitations are the most common complaint in cardiology outpatient clinics. These palpitations may be derived from paroxysmal atrial fibrillation (AF) and can be easily overlooked. It is unclear whether inter-atrial conduction time (ICT) may predict the paroxysmal AF in out-patients that present with palpitations. We evaluated the ability of the ICT to predict paroxysmal AF in these patients. Subjects and Methods: The study group consisted of 199 patients (110 female). All patients underwent 24-hour Holter electrocardiogram (ECG) monitoring (total of 327 Holter ECG monitorings, mean: 1.64 times per patient). Brief episodes of AF were documented in 35 patients (20 female, Group 1). The remaining patients without AF were designated as Group 2 (90 female). All patients underwent routine transthoracic echocardiographic examination. ICT was also measured by echocardiography. Results: The mean age in Group 1 was greater than in Group 2 (63.02±14 vs. 51.27±16 years, p<0.001). The left atrium was larger in Group 1 than in Group 2 (39.7±3.4 vs. 37.29±4.3 mm, p<0.001). The other echocardiographic variables were comparable between the two groups. The mean ICT was significantly higher in Group 1 than in Group 2 (138±14 vs. 114±12 msn, p<0.001). The ICT of 127 ms was predictive for AF with a sensitivity of 86% and specificity of 87% (p<0.001). Conclusion: Our findings show that ICT was prolonged in patients with palpitations who developed a brief episode of AF in Holter ECG monitoring. ICT prolongation may be used to identify patients with palpitation that are at risk of an AF episode. Holter ECG monitoring should be repeated to detect AF episodes in patients with prolonged ICT.

        • KCI등재SCIESCOPUS

          Effects of Minor Cu and Si Additions on Glass Forming Ability and Mechanical Properties of Co-Fe-Ta-B Bulk Metallic Glass

          Ziya,Ozgur,Yazici,Aytekin,Hitit,Yilmaz,Yalcin,Metin,Ozgul 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.1

          Effect of Cu and Si substitutions for Co and B on the glass forming ability (GFA) of Co(43-x)CuxFe20Ta5.5B(31.5-x)Siy (x=0-1.5 and y=5-10) were systematically investigated by X-ray diffraction, optical microscopy, scanning electron microscopy, and differential scanning calorimetry. In order to evaluate the contribution of copper and silicon, appropriate amounts of copper and silicon were individually introduced to the base alloy composition. By using the effects of copper and silicon together, significant enhancement was obtained and the critical casting thickness (CCT) of the base alloy was increased three times from 2 mm to 6 mm. Moreover, mechanical properties of the alloys were examined by compression tests and Vickers hardness measurements. The compression test results revealed that the glassy alloys having enhanced GFA shows high strength of about 3500- 4000 MPa. In addition, existence of (Co,Fe)2B and (Co,Fe)20.82Ta2.18B6 crystalline phases in glassy matrix influences the hardnesses of the alloys compared to monolitic glassy structure having hardness of about 1200 Hv.

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