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        Antimicrobial Nanocomposites Based on Oxidized Cotton Fabric and in situ Biosynthesized Copper Oxides Nanostructures Using Bearberry Leaves Extract

        Ana Krkobabić,Darka Marković,Aleksandar Kovačević,Vanja Tadić,Marija Radoičić,Tatjana Barudžija,Tatjana Ilic-Tomic,Maja Radetić 한국섬유공학회 2022 Fibers and polymers Vol.23 No.4

        The aim of this study was to develop antimicrobial nanocomposite textile material comprising of Cu-basednanostructures synthesized on oxidized cotton fabric using Arctostaphylos uva-ursi (L.) Spreng., Ericaceae (bearberry leaves)as a green reducing agent for adsorbed Cu2+-ions. In order to provide sufficient number of carboxyl groups for complexationwith Cu2+-ions a two-step oxidation process with NaIO4 and NaClO2 was carried out. The influence of NaIO4 concentrationon content of carboxyl groups and Cu-based nanoparticles was studied by FTIR and AAS. HPLC analysis identified thegallic acid known as a reducing agent in bearberry leaves extract. FESEM and XRD analyses revealed that using bearberryleaves extract and gallic acid solution as reducing agents led to a formation of spherical Cu2O/CuO nanoparticles and CuOnanosheets, respectively. These nanoparticles and nanosheets provided excellent antibacterial activity against Gram-negativebacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus. Cytotoxicity on human keratinocyte cells wasshown to depend on their copper content.

      • Tracheobronchopathia Osteochlastica: A Study of 22 Patients from Serbia

        ( Jovan Javorac ),( Dejan Zivanovic ),( Miroslav Ilic ),( Ivan Kopitovic ),( Ana Milenkovic ),( Nevena Savic ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

        Background Tracheobronchopathia osteochalstica (TO) is an indolent and rare airway disorder with a favourable prognosis, characterized by the presence of submucosal cartilage or bone nodules in the wall of the laryngotracheobronchial tree, that can lead to its narrowing. The aim of this study was to determine the frequency of this disorder in the general population, as well as to obtain basic socio-demographic characteristics of patients and the clinical manifestations of TO. Methods Endoscopic findings of patients who underwent bronchoscopy at the Institute for Pulmonary Diseases of Vojvodina, Serbia from 01.01.2013 to 01.01.2021 were analyzed. For patients in whom the existence of TO was confirmed, individual sociodemographic data were collected and clinical parameters were analyzed. Results Analysis of 14.545 bronchoscopic findings showed that TO was presented in 22 patients (0.15%). Our sample consisted of predominantly males (68.2%), while the mean age was 70.12. Approximately one-third of patients (32%) had a previously established respiratory disease (COPD and asthma most usually). In most cases, TO was found as an accidental finding during bronchoscopy indicated for other reasons (lung carcinoma in 50% of cases, inflammatory diseases of lung in 32%, other reasons in 18%). The trachea (especially its lower two-thirds) was the most common site of TO (73% of patients). The most common pre-bronchoscopic symptoms were cough, shortness of breath and chest pain. No significant narrowing of the laryngotracheobronchial lumen was found in any of the patients. Thus, none of them was treated with specific therapy for TO but received only symptomatic therapy and therapy aimed at the underlying respiratory disease. Conclusion Tracheobronchopathia osteochlastica is a rare and usually an underdiagnosed disorder. Its recognition can be important in everyday clinical practice, due to significant respiratory symptoms and impaired quality of life in patients with TO, as well as potential difficulties during endotracheal intubation.

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