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RISS 인기검색어
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- 저자 : ( Ana Milenkovic ) (검색결과 2 건)
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Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)
Marina Kolundzic,Tatjana Stanojkovic,Jelena Radovic,Ana Tacic,Margarita Dodevska,Marina Milenkovic,Francesca Sisto,Carla Masia,Giampietro Farronato,Vesna Nikolic,Tatjana Kundakovic 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.8
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 μg/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 ± 1.24–134.79 ± 0.01 μg/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, β-glucans, and polyphenolic compounds.
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Tracheobronchopathia Osteochlastica: A Study of 22 Patients from Serbia
( Jovan Javorac ),( Dejan Zivanovic ),( Miroslav Ilic ),( Ivan Kopitovic ),( Ana Milenkovic ),( Nevena Savic ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Tracheobronchopathia osteochalstica (TO) is an indolent and rare airway disorder with a favourable prognosis, characterized by the presence of submucosal cartilage or bone nodules in the wall of the laryngotracheobronchial tree, that can lead to its narrowing. The aim of this study was to determine the frequency of this disorder in the general population, as well as to obtain basic socio-demographic characteristics of patients and the clinical manifestations of TO. Methods Endoscopic findings of patients who underwent bronchoscopy at the Institute for Pulmonary Diseases of Vojvodina, Serbia from 01.01.2013 to 01.01.2021 were analyzed. For patients in whom the existence of TO was confirmed, individual sociodemographic data were collected and clinical parameters were analyzed. Results Analysis of 14.545 bronchoscopic findings showed that TO was presented in 22 patients (0.15%). Our sample consisted of predominantly males (68.2%), while the mean age was 70.12. Approximately one-third of patients (32%) had a previously established respiratory disease (COPD and asthma most usually). In most cases, TO was found as an accidental finding during bronchoscopy indicated for other reasons (lung carcinoma in 50% of cases, inflammatory diseases of lung in 32%, other reasons in 18%). The trachea (especially its lower two-thirds) was the most common site of TO (73% of patients). The most common pre-bronchoscopic symptoms were cough, shortness of breath and chest pain. No significant narrowing of the laryngotracheobronchial lumen was found in any of the patients. Thus, none of them was treated with specific therapy for TO but received only symptomatic therapy and therapy aimed at the underlying respiratory disease. Conclusion Tracheobronchopathia osteochlastica is a rare and usually an underdiagnosed disorder. Its recognition can be important in everyday clinical practice, due to significant respiratory symptoms and impaired quality of life in patients with TO, as well as potential difficulties during endotracheal intubation.
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