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- 저자 : Aiping Lu (검색결과 5 건)
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Hongwei Lu,Jianxin Du,Cuiping Yu,Xingping Wang,Yanlin Gao,Weizhong Xu,Aiping Liu,Xiaoxiao Lu,Yingxin Chen 한국고분자학회 2020 Macromolecular Research Vol.28 No.6
The development of high dielectric materials with high energy densities is a crucial research domain in the modern microelectronics and power systems. The objective of this work was to develop the highly ordered crystal orientations and large ferroelectric crystalline β/γ-phases in the biaxially oriented poly(vinylidene fluoride) (BOPVDF). Importantly, a high discharged energy density and high dielectric constant was achieved by using a high-electric-induced technique. A suitable poling electric field was applied to the BOPVDF films in order to enhance the breakdown strength. Remarkably, the BOPVDF film poled at the electric field of 113 MV m-1 achieved an unprecedented discharged energy density of 25.4 J cm-3 at an ultra-high electric field of 550 MV m-1, which is by far the highest value ever achieved in flexible polymer-based capacitor films. Comparatively, the unpoled BOPVDF and commercial biaxially oriented polypropylene (BOPP) exhibited only a discharged energy density of 7.9 J cm-3 and 1.2 J cm-3, respectively. This systematic study provides a new design paradigm to exploit PVDF-based dielectric polymers for capacitor applications.
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Cao Aiping,Gao Ling,Wang Fei,Tong Xuechen,Xie Shuangquan,Chen Xifeng,Lu Tianxin,Shen Haitao,Liu Hailiang,Jin Xiang,Li Hongbin 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: Mitogen-activated protein kinases (MPKs) play important role in response to environmental stress as crucial signal receptors or sensors. Our previous study indicated that salt stress acts as a positive factor to stimulate the production of pharmacodynamic metabolites in the medicinal plant Glycyrrhiza uralensis. Currently, little is known about the MPK gene family and their functions in the medicinal plant G. uralensis. Objective: Identification, comprehensive bioinformatic analysis, expression profiling, and response pattern under salt stress of the G. uralensis GuMPK gene family. Methods: Genome-wide investigation and expression profiling of the MPK gene family in G. uralensis, and their phylogenetic relationships, evolutionary characteristics, gene structure, motif distribution, promoter cis-acting element, and expression pattern under salt stress in two different salt-tolerant Glycyrrhiza species were performed. Results: A total of 20 G. uralensis GuMPK genes were identified and categorized into five groups, and had conserved gene structure and motif distribution. Expression profiling of GuMPK genes suggested their potentially diverse functions in plant growth and in response to phytohormones and environmental stress, particularly GuMPK1, 2, 5, and 10 as key components for G. uralensis in response to abiotic stress. Further expression analysis under NaCl treatment in two different salt-tolerant Glycyrrhiza species displayed the MPKs' different response patterns, emphasizing the role of MPK2, 5, 7, and 16 as potentially crucial genes for Glycyrrhiza to respond to salt stress. Conclusion: Our results provide a genome-wide identification and expression profiling of MPK gene family in G. uralensis, and establish the foundation for screening key responsive genes and understanding the potential function and regulatory mechanism of GuMPKs in salt responsiveness.
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Ling Fan,Zhao Chen,Wenbin Fu,Nenggui Xu,Jianhua Liu,Aiping Lu,Ziping Li,Shengyong Su,Taixiang Wu,Aihua Ou 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.5
This study aims to investigate the molecular mechanisms of acupuncture in the remission of depression. A depressive disorder model was induced by exposing Sprague–Dawley rats to chronic unpredictable stress. The rats were divided into five groups: healthy (blank group) and stressed rats (model group), and stressed rats treated with acupuncture (acupuncture group), riluzole (riluzole group), acupuncture combined with botulinum toxin A (BTX-A) injection (acupuncture+BTX-A group) or riluzole combined with BTX-A injection (riluzole+BTX-A group). Behavioral analysis showed significant differences in sucrose consumption, weight, and horizontal or vertical movements between the model and both the riluzole and acupuncture groups. No obvious differences between the riluzole+BTX-A and acupuncture+BTX-A groups were found. Moreover, no significance differences in glutamate content in the hippocampus were found among the riluzole+BTX-A, acupuncture+BTX-A and model groups (p>0.05). Western blots and reverse transcription polymerase chain reactions were employed to detect protein and mRNA expressions of VGLUT2, SNAP25, VAMP1, VAMP2, VAMP7, and syntaxin1; no obvious differences among the riluzole+BTX-A, acupuncture+BTX-A and model groups were found. These data suggest that soluble N-ethylmaleimide-sensitive factor attachment receptor proteins are involved in the remission of depression in rats treated with acupuncture.
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Ashraf, Zaman,Alamgeer,,Rasool, Raqiqatur,Hassan, Mubashir,Ahsan, Haseeb,Afzal, Samina,Afzal, Khurram,Cho, Hongsik,Kim, Song Ja,Zhang, Ge,Lu, Aiping MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.12
<P>Dexibuprofen–antioxidant conjugates were synthesized with the aim to reduce its gastrointestinal effects. The esters analogs of dexibuprofen <B>5a</B>–<B>c</B> were obtained by reacting its –COOH group with chloroacetyl derivatives <B>3a</B>–<B>c</B>. The in vitro hydrolysis data confirmed that synthesized prodrugs <B>5a</B>–<B>c</B> were stable in stomach while undergo significant hydrolysis in 80% human plasma and thus release free dexibuprofen. The minimum reversion was observed at pH 1.2 suggesting that prodrugs are less irritating to stomach than dexibuprofen. The anti-inflammatory activity of <B>5c</B> (<I>p</I> < 0.001) is more significant than the parent dexibuprofen. The prodrug <B>5c</B> produced maximum inhibition (42.06%) of paw-edema against egg-albumin induced inflammation in mice. Anti-pyretic effects in mice indicated that prodrugs <B>5a</B> and <B>5b</B> showed significant inhibition of pyrexia (<I>p</I> < 0.001). The analgesic activity of <B>5a</B> is more pronounced compared to other synthesized prodrugs. The mean percent inhibition indicated that the prodrug <B>5a</B> was more active in decreasing the number of writhes induced by acetic acid than standard dexibuprofen. The ulcerogenic activity results assured that synthesized prodrugs produce less gastrointestinal adverse effects than dexibuprofen. The ex vivo antiplatelet aggregation activity results also confirmed that synthesized prodrugs are less irritant to gastrointestinal mucosa than the parent dexibuprofen. Molecular docking analysis showed that the prodrugs <B>5a</B>–<B>c</B> interacts with the residues present in active binding sites of target protein. The stability of drug–target complexes is verified by molecular dynamic simulation study. It exhibited that synthesized prodrugs formed stable complexes with the COX-2 protein thus support our wet lab results. It is therefore concluded that the synthesized prodrugs have promising pharmacological activities with reduced gastrointestinal adverse effects than the parent drug.</P>
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