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RISS 인기검색어
- 검색키워드
- 저자 : Adnan Yilmaz (검색결과 5 건)
- 무료
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Oguzhan Yilmaz,Adnan A. Ugla 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.4
Shaped metal deposition (SMD) method would be an alternative way to traditional manufacturing methods, especially for complex featured and large scale solid parts and it is particularly used for aerospace structural components, manufacturing and repairing of die/molds and middle-sized dense parts. This method is implemented by depositing continuous cold or hot-water melted via welding arc plasma heat. This paper presents the designing, constructing, and controlling of an additive manufacturing system using TIG plus wire based Shaped metal deposition (TW-SMD) method. The aim of the current study is to design and develop an integrated system which is able to reduce time consuming and boring task of deposition process. The developed additive system is capable of producing near net shaped components of sizes not exceed 400 mm in 3 directions directly from CAD drawing. The results showed that the developed system succeeded to produce near net geometries and error-free depositions for various features of SS308LSi components. Additionally, workshop tests have been conducted in order to verify the capability and reliability of the developed AM system.
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Association of Insulin Resistance with Overactive Bladder in Female Patients
Hakki Uzum,Mehmet Kalkan,Adnan Yilmaz,Ahu Kemik,Orhan Unal Zorba 대한배뇨장애요실금학회 2012 International Neurourology Journal Vol.16 No.4
Purpose: Metabolic syndrome and obesity have been advocated to be risk factors for the development of overactive bladder (OAB). Additionally, insulin resistance is the underlying mechanism of metabolic syndrome. We aimed to investigate the association of insulin resistance with overactive bladder in female patients. Methods: We prospectively conducted the study in our urology department. Female patients aged between 30 and 76 years old applied to our policlinics with or without OAB symptoms were enrolled. One hundred and twenty-two patients with OAB and 62 age-matched controls without OAB were included into the study. Fasting serum insulin, glucose, high-density lipoprotein (HDL-c), and triglycerides levels were measured. Insulin resistance value was obtained via the homeostasis model assessment of insulin resistance (HOMA-IR) calculator. The chi-square and Mann-Whitney U tests were used to compare differences in variables. Results: Serum insulin level was found higher in female patients with OAB (11.5±6.2 μU/mL) relative to controls (6.4±2.1 μU/mL), statistically significant (P=0.036). In addition, HOMA-IR was significantly found higher in the OAB group, 2.86 (0.76 to 17.04) in comparison to controls, 1.32 (0.67 to 224), P=0.018. High-density lipoprotein cholesterol levels (HDL-c) were significantly found lower in females with OAB. Conclusions: Insulin resistance can be associated to overactive bladder and may play significant role in pathogenesis.
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Kum, Rauf Oguzhan,Ozcan, Muge,Baklaci, Deniz,Kum, Nurcan Yurtsever,Yilmaz, Yavuz Fuat,Gungor, Volkan,Unal, Adnan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: Laryngeal carcinogenesis is a multifactorial process that has not been fully elucidated. Despite extensive research, reliable markers with diagnostic and prognostic value are still lacking. It was recently reported that an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) may correlate with an increased risk of recurrence, tumor aggressiveness and poorer prognosis in various malignancies. The aim of this study was to examine whether NLR could be used as an inflammatory marker to differentiate laryngeal squamous cell carcinoma (LSCC) patients from benign laryngeal lesion (BLL) and precancerous laryngeal lesion (PLL) patients. Materials and Methods: This retrospective study was performed on 209 patients admitted to a tertiary referral center with laryngeal lesions and undergoing biopsies to establish their histopathological diagnosis. We reviewed the patient files for their clinical, histopathological and laboratory data. The patients were divided into three groups according to their histopathological findings, as BLL, PLL and LSCC groups. The patients in the PLL group were also divided into three subgroups as mild, moderate and severe dysplasia/carcinoma in situ (CIS) subgroups. The groups were compared for NLR and the other laboratory data. Results: The mean NLRs of the BLL, PLL and the LSCC groups were $2.12{\pm}0.86$, $2.32{\pm}0.68$ and $3.46{\pm}1.51$, respectively, and the difference was statistically significant (p=0.001). The mean NLRs of the patients with PLL and LSCC were significantly higher than the patients with BLL (p=0.031 and p=0.001, respectively). The mean NLRs were similar among mild dysplasia, moderate dysplasia and severe dysplasia / CIS groups (p>0.05). Conclusions: To our knowledge, this is the first study investigating NLR in BLL, PLL and LSCC. NLR is an inexpensive, reproducible and widely available blood test, and could be a useful inflammatory marker to differentiate LSCC from BLL and PLL.
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Correlation between SERT polymorphisms and Venlafaxine response in major depression patients
Nevzat Yuksel,Ozlem Dogan,Mehmet Ali Ergun,Hatice Ersin Karslioglu,Aysegul Koc,Akin Yilmaz,Mustafa N. Ilhan,Adnan Menevse 한국유전학회 2010 Genes & Genomics Vol.32 No.3
Major depression (MD) has a complex multifactorial aetiology with genetic and environmental factors contributing to this disorder. As with all antidepressant treatments, there is variability in drug response because of heredity, and this leads us to focus on the genetic polymorphism of the drug's metabolising transporter genes. The serotonin transporter (5-HTT) gene is a particularly important candidate for genetic involvement in MD disorders owing to its key role in the regulation of serotonergic transmission and is therefore considered an interesting candidate in the mechanism of antidepressant drugs. Here, we studied the associations between genetic polymorphisms in two regions of the 5-HTT gene (5-HTTLPR and VNTR) to understand venlafaxine response. Venlafaxine was found to be effective in MD patients based on their HAM-D and CGI scores (p<0.05). Although the results did not yield a significant difference between the frequencies of the SS, LS,LL, 9/9, 10/10, 12/12 and 10/12 genotypes and venlafaxine response, venlafaxine dose was increased in patients with Stin2.12 and S alleles. These alleles might have a predisposition to mood disorders. Further studies with more patients are required to confirm this clinical association.
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