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- 검색키워드
- 저자 : Abid Mehmood (검색결과 26 건)
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( Abid Mehmood Yousaf ),( Dong Wuk Kim ),( Yu Kyoung Oh ),( Chul Soon Yong ),( Jong Oh Kim ),( Han Gon Choi ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
Background: The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate. Methods: The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w/v) aqueous solutions of each carrier. The polyvinylpyrrolidone (PVP) nanospheres, hydroxypropyl-β-cyclodextrin (HP-β-CD) nanocorpuscles, and gelatin nanocapsules were formulated as fenofibrate/PVP/sodium lauryl sulfate (SLS), fenofibrate/HP-β-CD, and fenofibrate/gelatin at the optimized weight ratios of 2.5:4.5:1, 1:4, and 1:8, respectively. The three solid-state products were achieved using the solventevaporation method through the spray-drying technique. The physicochemical characterization of these nanoparticles was accomplished by powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Their physicochemical properties, aqueous solubility, dissolution rate, and pharmacokinetics in rats were investigated in comparison with the drug powder. Results: Among the tested carriers, PVP, HP-β-CD, gelatin, and SLS showed better solubility and were selected as the most appropriate constituents for various nanoparticulated systems. All of the formulations significantly improved the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to the drug powder. The drug was present in the amorphous form in HP-β-CD nanocorpuscles; however, in other formulations, it existed in the crystalline state with a reduced intensity. The aqueous solubility and dissolution rates of the nanoparticles (after 30 minutes) were not significantly different from one another. Among the nanoparticulated systems tested in this study, the initial dissolution rates (up to 10 minutes) were higher with the PVP nanospheres and HP-β-CD nanocorpuscles; however, neither of them resulted in the highest oral bioavailability. Irrespective of relatively retarded dissolution rate, gelatin nanocapsules showed the highest apparent aqueous solubility and furnished the most improved oral bioavailability of the drug (~5.5-fold), owing to better wetting and diminution in crystallinity. Conclusion: Fenofibrate-loaded gelatin nanocapsules prepared using the solvent-evaporation method through the spray-drying technique could be a potential oral pharmaceutical product for administering the poorly water-soluble fenofibrate with an enhanced bioavailability.
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AJFCode: An Approach for Full Aspect-Oriented Code Generation from Reusable Aspect Models
Abid Mehmood,Dayang N. A. Jawawi 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.6
Model-driven engineering (MDE) and aspect-oriented software development (AOSD) contribute to the common goal of development of high-quality code in reduced time. To complement each approach with the benefits of the other, various methods of integration of the two approaches were proposed in the past. Aspect-oriented code generation, which targets obtaining aspect-oriented code directly from aspect models, offers some unique advantages over the other integration approaches. However, the existing aspect-oriented code generation approaches do not comprehensively address all aspects of a model-driven code generation system, such as a textual representation of graphical models, conceptual mapping, and incorporation of behavioral diagrams. These problems limit the worth of generated code, especially in practical use. Here, we propose AJFCode, an approach for aspect-oriented model-driven code generation, which comprehensively addresses the various aspects including the graphical models and their text-based representation, mapping between visual model elements and code, and the behavioral code generation. Experiments are conducted to compare the maintainability and reusability characteristics of the aspect-oriented code generated using the AJFCode with the most comprehensive object-oriented code generation approach. AJFCode performs well in terms of all metrics related to maintainability and reusability of code. However, the most significant improvement is noticed in the separation of concerns, coupling, and cohesion. For instance, AJFCode yields significant improvement in concern diffusion over operations (19 vs 51), coupling between components (0 vs 6), and lack of cohesion in operations (5 vs 9) for one of the experimented concerns.
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( Abid Mehmood Yousaf ),( Omer Mustapha ),( Dong Wuk Kim ),( Dong Shik Kim ),( Kyeong Soo Kim ),( Sung Giu Jin ),( Chul Soon Yong ),( Yu Seok Youn ),( Yu Kyoung Oh ),( Jong Oh Kim ),( Han Gon Choi ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Purpose: The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate. Methods: Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP) and Labrafil® M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed, The solid state characterization of an optimized formulation was conducted by scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopic analyses. Oral bioavailability in rats was also evaluated for the formulation of an optimized nanospherule in comparison with free drug and a conventional fenofibrate-loaded solid dispersion. Results: All of the electrosprayed nanospherule formulations had remarkably enhanced aqueous solubility and dissolution compared with free drug, Moreover, Labrafil M 2125, a surfactant, had a positive influence on the solubility and dissolution of the drug in the elcctrospraycd nanospherulc. Increases were observed as the PVP/drug ratio increased to 4: I, but higher ratios gave no significant increases. In particular, an electrosprayed nanospherule composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of I :4:0,5 resulted in a particle size of <200 nm with the drug present in the amorphous state, It demonstrated the highest solubility (32,51±2.41μg/ml.), an excellent dissolution (-85% in 10 minutes), and an oral bioavailability -2,5-fold better than that ofthe free drug, It showed similar oral bioavailability compared to the conventional solid dispersion, Conclusion: Electrosprayed nanospherules, which provide improved solubility and bioavailability, are promising drug delivery tools for oral administration of poorly water-soluble fenofibrate.
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Yousaf, Abid Mehmood,Mustapha, Omer,Kim, Dong Wuk,Kim, Dong Shik,Kim, Kyeong Soo,Jin, Sung Giu,Yong, Chul Soon,Youn, Yu Seok,Oh, Yu-Kyoung,Kim, Jong Oh,Choi, Han-Gon Dove Medical Press 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P><B>Purpose</B></P><P>The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate.</P><P><B>Methods</B></P><P>Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP) and Labrafil<SUP>®</SUP> M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed. The solid state characterization of an optimized formulation was conducted by scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopic analyses. Oral bioavailability in rats was also evaluated for the formulation of an optimized nanospherule in comparison with free drug and a conventional fenofibrate-loaded solid dispersion.</P><P><B>Results</B></P><P>All of the electrosprayed nanospherule formulations had remarkably enhanced aqueous solubility and dissolution compared with free drug. Moreover, Labrafil M 2125, a surfactant, had a positive influence on the solubility and dissolution of the drug in the electrosprayed nanospherule. Increases were observed as the PVP/drug ratio increased to 4:1, but higher ratios gave no significant increases. In particular, an electrosprayed nanospherule composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of 1:4:0.5 resulted in a particle size of <200 nm with the drug present in the amorphous state. It demonstrated the highest solubility (32.51±2.41 μg/mL), an excellent dissolution (~85% in 10 minutes), and an oral bioavailability ~2.5-fold better than that of the free drug. It showed similar oral bioavailability compared to the conventional solid dispersion.</P><P><B>Conclusion</B></P><P>Electrosprayed nanospherules, which provide improved solubility and bioavailability, are promising drug delivery tools for oral administration of poorly water-soluble fenofibrate.</P>
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Yousaf, Abid Mehmood,Kim, Dong Wuk,Oh, Yu-Kyoung,Yong, Chul Soon,Kim, Jong Oh,Choi, Han-Gon Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P><B>Background</B></P><P>The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate.</P><P><B>Methods</B></P><P>The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w/v) aqueous solutions of each carrier. The polyvinylpyrrolidone (PVP) nanospheres, hydroxypropyl-β-cyclodextrin (HP-β-CD) nanocorpuscles, and gelatin nanocapsules were formulated as fenofibrate/PVP/sodium lauryl sulfate (SLS), fenofibrate/HP-β-CD, and fenofibrate/gelatin at the optimized weight ratios of 2.5:4.5:1, 1:4, and 1:8, respectively. The three solid-state products were achieved using the solvent-evaporation method through the spray-drying technique. The physicochemical characterization of these nanoparticles was accomplished by powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Their physicochemical properties, aqueous solubility, dissolution rate, and pharmacokinetics in rats were investigated in comparison with the drug powder.</P><P><B>Results</B></P><P>Among the tested carriers, PVP, HP-β-CD, gelatin, and SLS showed better solubility and were selected as the most appropriate constituents for various nanoparticulated systems. All of the formulations significantly improved the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to the drug powder. The drug was present in the amorphous form in HP-β-CD nanocorpuscles; however, in other formulations, it existed in the crystalline state with a reduced intensity. The aqueous solubility and dissolution rates of the nanoparticles (after 30 minutes) were not significantly different from one another. Among the nanoparticulated systems tested in this study, the initial dissolution rates (up to 10 minutes) were higher with the PVP nanospheres and HP-β-CD nanocorpuscles; however, neither of them resulted in the highest oral bioavailability. Irrespective of relatively retarded dissolution rate, gelatin nanocapsules showed the highest apparent aqueous solubility and furnished the most improved oral bioavailability of the drug (~5.5-fold), owing to better wetting and diminution in crystallinity.</P><P><B>Conclusion</B></P><P>Fenofibrate-loaded gelatin nanocapsules prepared using the solvent-evaporation method through the spray-drying technique could be a potential oral pharmaceutical product for administering the poorly water-soluble fenofibrate with an enhanced bioavailability.</P>
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Abid, Muhammad,Khan, Yasir Mehmood Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.46 No.6
This paper presents results of the effect of different bolt tightening sequences and methods on the performance of gasketed bolted flange joint using nonlinear finite element analysis. Bolt preload scatter due to elastic interactions, flange stress variation and bolt bending due to flange rotation and gasket contact stress variation is difficult to eliminate in torque control method i.e. tightening one bolt at a time. Although stretch control method (tightening more than one bolt at time) eradicates the bolt preload scatter, flange stress variation is relatively high. Flange joint's performance is compared to establish relative merits and demerits of both the methods and different bolt tightening sequences.
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Muhammad Abid,Yasir Mehmood Khan 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.46 No.6
This paper presents results of the effect of different bolt tightening sequences and methods on the performance of gasketed bolted flange joint using nonlinear finite element analysis. Bolt preload scatter due to elastic interactions, flange stress variation and bolt bending due to flange rotation and gasket contact stress variation is difficult to eliminate in torque control method i.e. tightening one bolt at a time. Although stretch control method (tightening more than one bolt at time) eradicates the bolt preload scatter, flange stress variation is relatively high. Flange joint’s performance is compared to establish relative merits and demerits of both the methods and different bolt tightening sequences.
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