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후천성 말단성 섬유각화종 - 항 Factor XIIIa 항체를 이용한 면역조직화학 염색 -
서호석(Ho Seok Suh),류병직(byung Jick Ryu),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.6
In normal hurnan dermis, factor XIIIa positive dermal dendrocyte are located in the papillary areas closely associated with blood vessels and the upper reticular dem These cells represent a specific type of bone marrow derived dermal cells, distinct from Langerhans cells having some features in common with rnonocyte/macrophage lineage and with potential antier presenting activity. Although the significance of these cells has not yet been fully established, it been suggested that they play a major role in skin immune iesponses, in collagen synsthesis regultic and in wound repair. We report a case of acaqired fibrokeratoma which is studiec conventional histopathology and immunohistochemistry. Histopathologic findings of this case showed ovascular proliferation and the increased presence of fibroblast like cells as a common fe;ture of these benign tumors. Immunohistochemical staining with anti factor XIIIa antibody deiaoi strates increased numbera of positive dendritic cells in the upper dermis. There finding supports the fat that some fibroblagt like cells in the upper dermis of acquireid fibrokeratoma may be factor XIIIa positive dermal dendritic cells. (Kor J Dermatol 1994; 32(6): 1131-1135)
서호석 ( Ho Seok Suh ),지민선 ( Min Sun Jee ),김형훈 ( Hyung Hun Kim ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.1
Cutaneous larva migrans(CLM) is a creeping cutaneous eruption that results from skin invasion by the larval form of nematodes. We experienced two patients who had typical clinical findings of CLM. One patient had a history of contact with possibly contami
서호석(Ho Seok Suh),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5
Beckground : Molluscum contagiosum is a common viral infect oudisease of the skin and mucous membrane that is caused by a molluscum contagiosum virus(MCV; which belongs to the poxviridae family. One of the characteristic histopathologic findings is an epidermal hyperplasia Porter and Archard reported that this phenomenon might be explained by a virus induced epidermal growth factor (EGF) like polypeptide. There was a report that epidermal prolifeation in viral infection might be modulated by other factors than the virus itself such as local immune response. Objective : The purpose of this study was to examine the expression pattern of epidermal growth factor receptor and other immunocompetent cells by immunohistochemical stainings. Method : We performed iinmunoperoxidase staining on the 11 slaecmens of formalin-fixed, paraffin-embedded molluscum lesions and 15 specimens of snap frozen mollucum lesions with nine primary antibodies(EGFR, factor XIIIa, CDla, S-100 protein, MAC 387, HLA-IR, CD4, CDS, L26) Results : EGF receptors were strongly expressed in lesional MCV ifect,ed keratinocytes. The number of CDla and factor XIIIa positive dermal dendritic cells were sigtly increased. In inflamed lesions, CD4 and HLA-DR expressions were increased in the dermis and per lesional epidermis. Conclusion : This study shows that 1) increased EGFR expression is of MCV infected keratinocytes may be related to the pathogenesis of epidermal hyperplasia. 2) helper T lyrnphocytes may operate in inflamed molluscum lesions. (Kor J Dermatol 1994;32(5):787-794)
주사 환자에서 경구 메트로니다졸 치료의 효용성에 대한 고찰
한석현 ( Seok Hyun Han ),서호석 ( Ho Seok Suh ),최유성 ( Yu Sung Choi ) 대한피부과학회 2017 대한피부과학회지 Vol.55 No.9
Background: Recent studies have revealed that several factors including Demodex mites induce an excessive immune response and that the skin lesions seen in patients with rosacea may develop as a result of excessive inflammation. Therefore, acaricidal and anti-inflammatory treatments such as systemic metronidazole have been shown to be efficacious for rosacea. Objective: This study aimed to evaluate the efficacy of systemic metronidazole in the treatment of rosacea. Methods: A group of 39 patients diagnosed with rosacea who visited the Department of Dermatology of Ulsan University Hospital from April 2014 to July 2015 was investigated in this single-center retrospective study. Patients were treated with metronidazole 250 mg 3 times daily for 3 weeks. The response was evaluated using serial photographs of the patients. According to clinical improvement, patients were classified into an effective group and a failure group. Results: After treatment, 29 patients (74.4%) responded to systemic metronidazole treatment. Fourteen patients (48.3%) in the effective group were well controlled without recurrence for 20.1 weeks. Patients in the effective group showed a higher detection rate of Demodex mites and proportion of the papulopustular rosacea subtype than patients in the failure group. Conclusion: The results of this study showed that systemic metronidazole was a tolerable and effective option for the treatment of patients with papulopustular rosacea with Demodex mites. Moreover, the early treatment of inflammatory lesions leads to an improved prognosis. (Korean J Dermatol 2017;55(9):557∼564)
위축성 여드름 흉터에서 두 가지 국소 화학 박피술의 치료 효과 ; 100% TCA CROSS와 Phenol CROSS의
채웅석 ( Woong Suk Chae ),서호석 ( Ho Seok Suh ),최유성 ( Yu Sung Choi ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.5
Atrophic acne scars have been treated using various modalities. The CROSS (Chemical Reconstruction of Skin Scars) technique using 100% TCA has the advantage of reconstructing acne scars by focusing on dermal thickening and collagen production. However, the phenol CROSS technique is not widely used for acne scarring. Objective: The purpose of this study was to evaluate the clinical effectiveness and safety of 100% TCA CROSS and phenol CROSS in the treatment of facial atrophic acne scars. Methods: Twenty-four participants were randomly and equally divided into 2 groups: group 1 received 2 sessions (8 weeks apart) of 100% TCA CROSS, while group 2 received 2 sessions (8 weeks apart) of phenol CROSS. The severity of atrophic acne scarring and treatment efficacies were evaluated by standardized photography, patient satisfaction, physician global assessment, and the ECCA grading scale. Side effects were assessed at the 8- and 20 week visits. Results: At the 0-, 8-, and 20-week visits, both groups showed an acceptable improvement in patient satisfaction and physician global assessment. ECCA grading scale scores improved by a mean of 22.2% (p<0.05) in group 1 and 19.1% (p<0.05) in group 2. The between-group difference in the degree of ECCA score improvement was not statistically significant (p=0.392). Complications such as pain, crust, postcrust erythema, postcrust dryness, and postinflammatory hyperpigmentation were observed in both treatment groups. However, no severe side effects occurred in either group. Conclusion: Both 100% TCA CROSS and phenol CROSS are effective treatment modalities for atrophic acne scarring without significant side effects. (Korean J Dermatol 2014;52(5):293∼301)
주의력 저하 아동에 대한 뉴로피드백 치료의 주의집중력 향상
신기석,이영진,이용호,성형모,서호석,Sin, Ki-Seok,Lee, Young-Jin,Lee, Yong-Ho,Sung, Hyung-Mo,Suh, Ho-Suk 한국정신신체의학회 2009 정신신체의학 Vol.17 No.1
Objectives : This research is to figure out the neurofeedback treatment for the inattentive children is effective in improving attention deficit and furthermore, in relieving hyperactivity and impulsivity. Methods : 20 children subjects participated for this study. C3-A1 protocol neurofeedback was given 15 to 20 times to each child, it is carried out to compare the degree of attention in each case every 5 times of neurofeedback by using ADHD Rating Scale-IV : Parent Version(ARS) and Attention Deficit Disorder Evaluation Scale-Home Version(ADDES-HV). Results : The subscale of mean inattention score of ARS was reduced from 14.2 to 8.8 significantly(p<0.05) after 20 sessions of neurofeedback treatment, also the subscale of mean impulsivity/hyperactivity score of ARS from 13.3 to 7.1. The subscales of mean inattention, impulsivity and hyperactivity score of ADDES-HV was also reduced significantly(p<0.05) after 20 sessions of neurofeedback treatment. The changes of scores appeared significantly(p<0.05) from 10-15 sessions of neurofeedback treatment. Conclusion : The results of this study suggest that neurofeedback can improve children's attention deficit, hyperactivity and impulsivity, there exists the possibility of being a method to treat ADHD. 연구목적 : 본 연구에서는 주의집중력이 저하된 아동에게 뉴로피드백 훈련이 주의집중력의 향상에 효과가 있는가를 알아보고, 더 나아가 과잉행동(hyperactivity)과 충동성(impulsivity)의 호전에 효과가 있는가를 알아보고자 하였다. 방법 : 본 연구에서는 주의집중력이 저하된 아동 20명을 대상으로 각 아동별로 뉴로피드백 C3-A1 프로토콜을 15~20회 시행하였으며, 뉴로피드백 시행 전과 후의 주의집중력 정도를 ADHD Rating Scale-IV : Parent Version(ARS)과 Attention Deficit Disorder Evaluation Scale-Home Version(ADDES-HV)을 이용하여 비교하였다. 결과 : ARS 점수는 뉴로피드백 시행 전 inattention 소척도 평균 점수 14.2점에서 20회 시행 후의 평균 점수 8.8점으로 유의하게(p<0.05) 감소하였으며, impulsivity/hyperactivity 소척도의 평균 점수는 13.3점에서 7.1점으로 유의하게 감소하였다. ADDES-HV의 경우는 뉴로피드백 시행 전 inattention 소척도 평균 점수 34.8점에서 20회 시행 후의 평균 점수 20.7점으로 유의하게 감소하였으며(p<0.05), impulsivity 소척도는 22.5점에서 12.7점, hyperactivity 소척도는 18.8점에서 9.9점으로 유의하게 감소하였다. 이 점수들은 대개 10~15회 시점부터 유의하게 변화하기 시작하였다. 결론 : 뉴로피드백 치료를 통하여 아동의 주의집중력, 과잉행동, 충동성이 호전되었으며, 이는 뉴로피드백이 주의력 향상, ADHD의 치료에 한 방법이 될 수 있는 가능성을 시사하고 있다.
혈관중심성 T - 세포 림프종 : 4예의 임상 및 병리조직학적 관찰
지두현 ( Doo Hyun Chi ),서호석 ( Ho Seok Suh ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),허주령 ( Joo Ryung Huh ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.4
Background: Angiocentric T-cell lymphoma(AL) is a rare subtype of cutaneous T-cell lymphoma and recently many cases have been reported from Taiwan and Japan. But little is known about the clinical and histopathologic features of AL and few data are available in Korea. Objective : Our purpose was to characterize the clinical and histopathologic features of the specific cutaneous manifestauons of AL and to investigate the association with Epstein-Barr virus (EBV), Methods : Clinical records and histopathologic evaluation of skin biopsy specimens from four patients with AL were reviewed. We also performed immunohistochemical staining using monoclonal antibodies against, surface markers of lymphocytes and in situ hybridization for EBV-encoded RNA(EBER) in lesional skin. Results : 1. The most common clinical finding in our patients was indurated plaque predominantly on the trunk. 2. The common histopathologic finding in skin biopsy specimens from all four patients was angiocentric, angioinvasive, and angiodestructive infiltrate containing atypical lymphocytes. 3. In three of four patients, EBER was demonstrated in lesional skin by in situ hybridization. Conclusion : AL is an unique clinicopathologic entity showing strong association with EBV in Korea. (Kor J Dermatol 1996;34(4): 555-560)