프로톤펌프억제제 포함 표준요법 실패 후 Helicobacter pylori 감염 구제요법

서영환 ( Young Hwan Seo ),이수연 ( Su Yeon Rhie ),박범준 ( Bum Joon Park ),김형준 ( Hyung Joon Kim ),김재규 ( Jae Gyu Kim ) 대한내과학회 2008 대한내과학회지 Vol.74 No.1

목적: 국내에서 Helicobacter pylori를 제균하기 위해 사용되는 PPI 표준 삼제요법과 bismuth 포함 사제 요법은 적지 않은 제균 실패율은 보이고 있다. 이번 연구의 목적은 일차제균 치료에 실패한 환자에서 이차 치료로 bismuth 포함 사제요법과 삼차 치료로 rifabutin 포함 삼제요법의 H. pylori 제균율을 분석하고, 구제요법으로서의 역할에 대해 알아보고자 하였다. 방법: 2004년 7월부터 2006년 10월까지 중앙대학교 필동병원과 용산 병원을 내원하여 상부위장관 내시경 검사에서 H. pylori 감염 진단을 받고 PPI 삼제요법 치료에 실패한 52명의 환자를 대상으로 이차 bismuth 삼제요법을 시행하였다. 또한 이차 제균에 실패한 3명의 환자를 대상으로 rifabutin 포함 삼제요법으로 삼차 구제요법을 시행하였다. 또한 연령, 성별, 질환, 음주, 흡연, 그리고 NSAIDs 복용력에 따른 제균율을 분석하였다. 결과: Bismuth 포함 사제요법의 제균율은 84.6%였으며, rifabutin 포함 삼제요법의 제균율은 100%였다. 연령, 성별. 질환, 음주, 흡연, 그리고 NSAIDs 복용력에 따른 의미있는 통계학적 유의성은 보이지 않았다. 결론: Bismuth 포함 사제요법은 PPI 포함 일차 삼제요법 실패 후 이차 치료로 여전히 효과적이며, rifabutin 포함 삼제요법도 국내에서 이차 치료 실패 시 삼차 구제요법으로 사용되어질 수 있을 것으로 생각한다. Background/Aims: Proton pump inhibitor (PPI)-based standard triple therapy for Helicobacter pylori infection is widely used, but it has a considerable failure rate. The aim of this study was to evaluate the efficacy and tolerability of rescue therapies with a quadruple regimen and a rifabutin-based regimen for patients who experienced failure with PPI-based standard triple therapy. Methods: From July 2004 through October 2006, 52 patients for whom first-line triple therapy (PPI, amoxicillin and clarithromycin) had failed were included in this study. They were treated with a quadruple regimen for 7 days (PPI, bismuth, tetracycline and metronidazole) as a second-line therapy. For third?line therapy, a rifabutin-based regimen (PPI, rifabutin and amoxicillin) was prescribed for 14 days. The H. pylori status was determined before and at least 4 weeks after therapy by the 13C urea breath test or by endoscopy with antral and corpus biopsies for a rapid urease test, histological examination and culture. Results: The mean age was 52.6 years. Thirteen patients (25%) of the 52 patients were dropped. The eradication rate of the quadruple therapy was 84.6% (33/39). Three patients of the 6 failures with quadruple therapy were then treated with the rifabutin-based regimen. The eradication rate of the rifabutin-based therapy was 100% (3/3). Adverse effects (10.2%) were reported in 4 patients who were treated with quadruple regimen. Conclusions: The quadruple regimen is still an effective second-line therapy for Korean patients who experience failure with PPI-based standard triple therapy. The rifabutin-based regimen could be used as a third-line rescue therapy in Korea. (Korean J Med 74:23-29, 2008)

사회체육진흥을 위한 학교와 지역사회 및 관련단체의 역할 : 운동과학 : 폐기능 향상을 위한 장 , 단기간의 훈련효과

서영환(Young Hwan Seo),위승두(Seung Doo Wee),윤오남(Oh Nam Yoon),나승희(Seung Hee Na) 한국사회체육학회 2001 한국사회체육학회 학술대회 Vol.- No.-

비만중년여성의 동영상 콘텐츠를 활용한 홈 트레이닝이 스트레스효소, 비만도 및 생리적 특성에 미치는 영향

서영환(Young-Hwan Seo),손연희(Youn-Hee Son) 한국발육발달학회 2021 한국발육발달학회지 Vol.29 No.4

The purpose of this study was to investigate the effects of stress enzymes, obesity, and physiological characteristics changes in obese middle-aged women by using video content exercise methods. Exercise using video content was 50 minutes a day for a total of 8 weeks, and the following conclusions were obtained. There was a significant difference between the groups in α-amylase, a stress enzyme, and there was an interaction effect between the measurement period × the group. In addition, as the result of the decrease in body weight in the degree of obesity, there was an interaction effect between the measurement period × the group. The body fat percentage showed a significant difference according to the measurement period, and there was an interaction effect between the measurement period × the group. There was no significant effect on BMI. In the change of physiological characteristics, TC showed an interaction effect between measurement period × group, and TG showed no significant effect. Therefore, fitness bag exercise using YouTube reduced stress enzymes in obese middle-aged women, improved obesity and showed positive changes in physiological characteristics. Even if middle-aged obese women cannot participate in the exercise center due to the recent corona virus, if their will and active participation are supported, they will be able to show the effect of exercise at home.

점핑 다이어트 프로그램이 비만중년여성들의 생활습관병 관련인자와 혈중스트레스 요인에 미치는 영향

서영환(Young-Hwan Seo),오장록(Jang-Rok Oh) 한국발육발달학회 2019 한국발육발달학회지 Vol.27 No.3

The purpose of this study is to investigate the effect of the jumping diet program, which is popular in GX exercise, on lifestyle - related factors and blood stress in obese middle - aged women. Subjects underwent a 40-minute-a-day exercise three times a week for eight weeks and to determine the difference between before and after exercise, a t-test of the corresponding sample was conducted and the following conclusions were drawn. The results of decreasing body weight and body fat percentage after exercise were found to be statistically significant. In addition, it was decreased in TC, LDL-C and TG, which are lifestyle-related factors, and HDL-C was increased, resulting in statistically significant results, and the fasting blood glucose level was maintained to be normal. And blood stress did not enter the normal range, but decreased, indicating a significant difference. Taken together, the jumping diet exercise program improves body composition items and lifestyle-related factors in obese middle-aged women and reduces blood stress. Although the duration of jumping exercise was relatively short, it was thought that improvement of body shape and lifestyle - related factors were obtained for middle - aged obese women through 30 minutes of high intensity exercise and muscle power supplementation exercise. If I continue this exercise for a long time, I think it is one of the exercise programs that can relieve middle age obesity and maintain health.

걷기운동이 비만남자 대학생의 신체조성과 혈중 Adiponectin, Ghrelin, Resistin 및 인슐린 저항성에 미치는 영향

서영환(Young Hwan Seo),손연희(Youn Hee Son),위승두(Seung Doo Wee) 한국발육발달학회 2011 한국발육발달학회지 Vol.19 No.2

The purpose of this study was to investigate effects of walking exercise on body composition, insulin resistance, circulating concentration of diponectin, ghrelin and resistin in obese male university students. Subjects were divided into control group (n = 14) and walking exercise group (n = 13). Walking exercise was performed 4 times a week at the intensity of 65-75% HRmax (1-4 weeks: 65% HRmax, 5-8 weeks: 70% HRmax, 8-12 weeks:75% HRmax). And the change of body composition, blood glucose, insulin, HOMA-IR, adiponectin, ghrelin and resistin has been measured before and after 12 weeks of exercise. Statistical technique for data analysis was two-way ANOVA to determine the difference between before and after 12 weeks of walking exercise. As a result, body weight, BMI, and VO_2max were significantly improved during post-exercise. The change of adiponectin, ghrelin and resistin in experimental group was significantly changed after 12-week walking exercise. The present study provides the possibility that walking exercise may be a critical mediator to improve insulin resistance, concentrations of adiponectin, ghrelin and resistin in obese male university students.

걷기운동프로그램이 비만중년 여성의 혈장 고감도 C-반응성 단백(hs-CRP), Interlukin-6 및 TNF-α에 미치는 영향

서영환(Young Hwan Seo),강선영(Sun Young Kang),강형숙(Hyoung Sook Kang),김영표(Young Pyo Kim),윤진환(Jin Hwan Yoon) 한국사회체육학회 2009 한국사회체육학회지 Vol.0 No.37

The purpose of this study was to investigate the effect of walking program on plasma hs-CRP, interlukin-6 and TNF-α in obese middle-aged women. The subjects for this study were composed of twenty-three obese middle-aged women. The subjects were classified to two groups; control group(CG, n=13), walking exercise group(WEG, n=15). The WEG exercised for 12 weeks and were monitored for changes in BMI(body mass index), C-reactive protein(CRP), interlukin-6(IL-6), and tumor necrosis factor-alpha(TNF-α). The results of this study are as follow; BMI was significantly decreased in WEG after 12 weeks of walking exercise. CRP, IL-6, and TNF-α were significantly decreased in WEG after 12 weeks of walking exercise. CRP, IL-6, and TNF-α showed a significant correlation with BMI. In conclusion, the results of this study suggest that walking exercise can contribute to the better benefit in BMI, CRP, IL-6, and TNF-α for obese treatment.

체육계열 대학생의 전공연계 봉사활동 참여 동기에 따른 전공만족도, 직업가치관 형성, 진로준비행동의 관계 분석

서영환(Young-Hwan Seo),유한나(Han-Na Yu),이강찬(Kang-Chan Lee),신진화(Jin-Hwa Shin) 한국발육발달학회 2017 한국발육발달학회지 Vol.25 No.2

This Dissertation analyzes the relationship among satisfaction with majors, establishment of job values, and behavior for course preparation, depending on university student"s participation motivation in voluntary service activity related with Majors. First, the factors of self-development motivation and great cause motivation, parts of participation motivation, had affirmative effects on satisfaction with subjects, satisfaction with relationship, and satisfaction with recognition. Great cause motivation, a part of participation motivations, had an affirmative effect on satisfaction on lessons. Second, the factor of leisure motivation, a part of participation motivation, had an affirmative effect on course recognition, a part of job values, and the factors of self-development motivation, great cause motivation, and leisure motivation, parts of participation motivations, had an affirmative effect on job selection a part of job values. Third, the factors of self-development motivation, a part of participation motivation, had an affirmative effect on preparation behavior, a part of course preparation behaviors, and the factors of self-development motivation and leisure motivation, the parts of participation motivation, had an affirmative effect on exploration activity, a part of course preparation activity.

사회 비교 피드백이 운동 기술의 파지 및 전이에 미치는 영향

서영환(Young Hwan Seo),한남익(Nam Ik Han),안정덕(Jeong Deok Ahn) 한국발육발달학회 2013 한국발육발달학회지 Vol.21 No.4

Most research on feedback has focused on its informational role. In contrast, motor learning researchers have somewhat neglected the motivational aspects of feedback, perhaps because motivation is often assumed to exert only temporary effects on performance or to have, at best, indirect effects on learning through increased practice. But more recently, studies following up on findings indicating that learners preferred to receive feedback after good trials have shown that providing feedback after relatively successful trials can enhance motor learning relative to feedback after less successful trials. This study examined motivational effects of feedback on motor learning. Specifically, we investigated the influence of social-comparative feedback on the motor learning of a badminton short serve task. Twenty-eight university students with mean age of 19 years took part in this experiment. Participants were randomly assigned to the positive feedback and control groups, with an equal number of females in each group. The practice data were analyzed in 2(groups)×6(blocks of 10 trials) analyses of variance (ANOVAs) with repeated measures on the last factor. The retention and transfer data were analyzed in seperate one-way ANOVAs. Bothe groups reduced their absolute and variable errors across the practice phase. The main effect of block was significant p<.001. And on the transfer test, requiring novel absolute short serve, the social-comparative group had smaller errors than the control group(p<.05). The findings of the present study demonstrated evidence that motivational factors have transient effects on motor performance and affect motor learning.

한국과 일본 초등학생의 체육교과 선호도, 영역별 선호도, 방과 후 놀이 선호도 및 운동의 즐거움 요인 비교 연구

서영환(Youngwhan Seo),남윤신(Younshin Nam),최태희(Taehee Choi),靑柳領(Osamu Aoyagi),池田孝博(Takahiro Ikeda),한남익(Namik Han) 한국발육발달학회 2017 한국발육발달학회지 Vol.25 No.2

The purpose of this study was to investigate the preference of physical education contents, afterschool play and factors of physical pleasure derived from physical activity in Korea and Japan elementary students. The results of this study are as followed. Firstly, Japan subjects showed significantly high preference than that of the Korea subjects. Korea physical education showed significantly high than that of the other subject. Japan physical education, practical subject and arts subject showed significantly high than that of the other subject. Secondly, Japanese physical education contents showed significantly high preference than that of the Korean physical education contents. Japanese male students showed significantly high than that of the korean male students, Japanese female students and korean female student. Japanese T&F showed significantly high preference than that of the Japanese gymnastics, korean ball game, Japanese swimming, korean T&F, korean gymnastics, korean swimming. Third, It became clear that the gender and a after-school play factor have an influence on the preference of after-school play. Japanese of the preference of after school play showed significantly high than that of the korean. Japanese male students showed significantly high preference than that of korean male students, Japanese female students and korean female student. Lastly, It became clear that the gender and factor of PPA have an influence on the preference of PPA. PPA of Japanese showed significantly high than that of the korean PPA. Japanese male students showed significantly high preference than that of Japanese female students and korean female student.

초등학교 스포츠강사의 고용불안에 따른 직무만족, 조직헌신 및 처우개선에 관한 연구

서영환(Seo, Yeong-Hwan),김수교(Kim, Su-Kyo),이태형(Lee, Tae-Hyeong),이현정(Lee, Hyun-Jung),배두열(Bae, Du-Yol) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.3

This study drew the conclusion, basing on the study on duty satisfaction, organization contribution, and treatment improvement due to elementary school sports teacher"s employment anxiety. The factor of work anxiety and of welfare circumstances related to employment anxiety had a significant effect on work circumstance, worth, and pride related to duty satisfaction. The factor of welfare circumstance related to employment anxiety had a significant effect on autonomy and professionality, and the factor of work anxiety related to employment anxiety had a significant effect on human relation related to duty satisfaction. Second, the factor of work anxiety related to employment anxiety had a significant effect on organization faithfulness related to organization contribution, the factor of work anxiety related to employment anxiety had a significant effect on autonomy related to organization contribution, and the factor of welfare circumstance related to employment anxiety had a significant effect on worth acceptance related to organization contribution. Third, the factor of work and of welfare circumstance related to employment anxiety had a significant effect on treatment improvement.