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- 저자 : 배숙향 ( Hyang) (검색결과 3 건)
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증례 : 혈액종양 ; 불응성 급성전구B림프모세포백혈병 환자에서 발생한 장기종 1예
배숙향 ( Suk Hyang Bae ),황진연 ( Jin Yeon Hwang ),김동균 ( Dong Kyun Kim ),김민식 ( Min Sik Kim ),권희진 ( Hee Jin Kwon ),한진영 ( Jin Yeong Han ),김성현 ( Sung Hyun Kim ) 대한내과학회 2011 대한내과학회지 Vol.80 No.4
장기종은 소화기 장벽내 공기가 축적되는 방사선학적 소견이다. 장기종의 원인은 매우 다양하여 그 원인이 아직 명확하지 않다. 백혈병 환자에서 장기종은 약물치료 및 수술적 치료가 필요한 드문 합병증이다. 대부분의 장기종은 경과 및 예후가 좋은 편이지만 응급수술이 필요한 경우도 있으므로 치료 결정이 어려울 때가 많다. 저자들은 불응성 급성전구B 림프모세포백혈병 환자에서 백혈병의 진행과정으로서 장기종이 발생하여 결국 패혈증으로 사망한 증례를 경험하여 보고하는 바이다. Pneumatosis intestinalis (PI) is an imaging phenomenon that represents air in the bowel wall. The cause of PI is variable, although specific etiologic factors remain unknown. It is an infrequent complication in leukemia patients and is associated with several medical and surgical conditions. PI often represents a benign condition, but it can also require surgery. Therefore, the assessment of PI with or without complications can be difficult. Herein, we report on an unusual case of a 63 year-old woman with refractory acute precursor B-cell lymphoblastic leukemia-lymphoma who presented with PI resulting from the leukemic process, and finally expired due to sepsis. (Korean J Med 2011;80:482-485)
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HBeAg 양성 만성 B형 간염환자에서 Clevudine, Entecavir 및 Lamivudine의 초치료 효과
배숙향 ( Suk Hyang Bae ),백양현 ( Yang Hyun Baek ),이성욱 ( Sung Wook Lee ),한상영 ( Sang Young Han ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.6
Background/Aims: Clevudine is a potent antiviral agent that has demonstrated efficacy in patients with chronic hepatitis B. This study compared the efficacy of clevudine (C), entecavir (E) and lamivudine (L) in treatment-naive patient with HBeAg-positive chronic hepatitis B. Methods: A total of 146 treatment-naive patients with HBeAg-positive chronic hepatitis B received clevudine, entecavir or lamivudine. C group (n=39) received 30 mg of clevudine, E group (n=39) received 0.5 mg of entecavir and L group (n=68) received 100 mg of lamivudine once a day for more than 48 weeks. The efficacy analysis estimated the mean changes of the HBV DNA levels as a virologic response, the normalization of the ALT levels (less than 35 IU/L) as a biochemical response and loss of HBeAg or seroconversion as a serologic response. The serum HBV DNA level was quantified by hybrid capture and real-time PCR assay. Results: Before the administration of clevudine, entecavir and lamivudine, the mean HBV DNA and ALT levels and the gender and age were well balanced among the three groups (p>0.05). For the virologic response at 48 weeks, the mean changes of the HBV DNA levels from baseline of the C, E and L groups were -3.8±2.2, -4.5±1.9 and -2.5±2.1 log copies/mL. C and E group showed superior antiviral activity compared to that of L group (p<0.0001), but no significant differences in antiviral response were noted between C and E groups. For the biochemical response at 48 weeks, the normalization of the ALT levels (less than 35 IU/L) among the C, E and L groups was 82%, 74% and 71%, respectively (p=0.46). The rates of undetectable serum HBV DNA (less than 300 copies/mL) of the C, E and L groups were 39%, 69% and 27%, respectively (p<0.0001). For the serologic response at 48 weeks, the loss of HBeAg was 13%, 31% and 24% and the seroconversion was 10%, 23% and 17%, respectively. There was no difference of efficacy among the three groups regarding ALT normalization or serologic response (p>0.05). Viral breakthrough in C group was noted at 24 weeks (5%) and 48 weeks (21%), but no biochemical breakthrough was noted. The elevation of the serum CK level was noted in only 1 patient of group C at 48 weeks (2.56%) after therapy. For the patients without or with liver cirrhosis (LC), C and E group showed superior antiviral activity compared to that of the L group, but the antiviral activity was more effective in non-LC group than LC group (p<0.0001 vs p=0.036). Conclusions: Clevudine therapy compared with lamivudine for 48 weeks showed significantly potent antiviral efficacy in treatment-naive patients with HBeAg-positive chronic hepatitis B, and especially in the non-LC patients. However, the antiviral efficacy of clevudine was similar to that of entecavir even though taking into account relatively short follow up period and retrospective study. (Korean J Gastroenterol 2010;56:365-372)
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혈액투석 환자에서 관상동맥질환의 예측인자로서 단순방사선 촬영상 혈관 석회화 점수들간의 비교
김정민 ( Jung Min Kim ),안원석 ( Won Suk An ),김기현 ( Ki Hyun Kim ),김성은 ( Seong Eun Kim ),손영기 ( Young Ki Son ),정석희 ( Seuk Hee Chung ),오유정 ( You Jeong Oh ),김우재 ( Woo Jai Kim ),김동균 ( Dong Kyun Kim ),배숙향 ( Hyang 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.2
Purpose: Vascular calcification (VC) scores on simple plain radiographic films are known to be associated with coronary artery disease (CAD) and mortality. The present study was designed to demonstrate a correlation between VC scores of the hands and pelvis, and feet and lateral lumbar spine on plain radiographs. In addition, we analyzed the usefulness of checking all the plain radiographs for assessment of pre-existing CAD. Methods: We recruited 61 hemodialysis (HD) patients from OO Dialysis Center. We checked the plain radiographic films of the feet, hands, pelvis, and lateral lumbar spine and evaluated VC scores with previously reported methods. We defined CAD based on myocardial scans, echocardiography, or coronary angiography. Results: Positive associations were found between the VC scores of the feet, VC scores of the hands and pelvis, scores of abdominal aortic calcifications (AACs), and CAD. Approximately 30% of patients who had CAD could be missed based on a single VC scoring method. Patients who showed any one finding among the AAC scores >5, VC scores of the pelvis and hands >3 or arterial media calcifications of the feet on plain radiographs had a high sensitivity (93.8%) and a high negative predictive value (96.3%) for the presence of CAD. Conclusion: Each VC score was highly inter-correlated. All three VC scoring methods on plain radiographic films are useful screening tests for the presence of CAD in HD patients.
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