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Blue nevus is a neoplasm composed of pigmented dendritic dermal melanocytic cells in the reticular dermis. The lesion clinically presents as a well dermacated cerulean-blue or bluish black colored papule or plaque that usually measure less than 1 cm in diameter. Pilar sheath acanthoma is a rare, benign follicular hamartoma commonly affecting middle-aged and elderly individuals. It is characterized by a small, solitary, skin colored papule situated on the head and neck, particularly around the upper lip. We report a rare case of a blue nevus associated with a pilar sheath acanthoma in a 26 year-old man presented with a bluish papule on the neck. (Korean J Dermatol 2013;51(10):814∼816)
Bisphosphonates are widely used, though gastrointestinal tolerance is a problem on daily administration. Intermittent regimen, from once weekly to once yearly, is now available in overseas and can overcome GI adverse events. New generation of anti-resorptive agents (anti-RANKL antibody and a new SERM, bazedoxifene) are promising and will be soon available for the treatment of osteoporosis. Anabolic agents such as teriparatide and strontium ranelate have marked effects on BMD and reduction on fracture risk. While none of these options is suitable for everyone, the range of future available therapies does mean that most patients can find an intervention that is effective and acceptable. Now I introduce new antiresorptive drugs (Denosumab, Integrin inhibitor, Cathepsin K inhibitor) and new bone formation drugs (PTH-Teriparatide, Strontium Ranelate, Antisclerostin Ab-Sclerostin inhibitor, 2MD, Other Wnt-signaling related drugs).
Squamous cell carcinoma on the lip is a common oral malignancy, and it is responsible for >30% of all oral squamous cell carcinomas. Numerous factors have been implicated in the development of squamous cell carcinoma on the lip, but the most frequently identified risk factors include chronic exposure to ultraviolet radiation. Squamous cell carcinoma on the lip is more prevalent in elderly men, with a male-to-female ratio of 5:1. We report an interesting case of squamous cell carcinoma mimicking herpes simplex on the lip in a 35-year-old woman who presented with erythematous grouped vesicles on the upper lip.
Background: Melasma has been shown to have a significant emotional and psychological effect on affected patients. Objective: The aim of this study is to evaluate the usefulness of the Melasma Quality of Life Scale (MELASQOL) as compared to Dermatology Life Quality Index (DLQI). Methods: A total of 74 female patients of melasma were asked to complete a questionnaire of MELASQOL, DLQI, and additional demographic data. The degree of melasma was determined on the basis of clinical photos by the investigator using the Melasma Area and Severity Index (MASI). Results: The mean age of these patients was 46.3±8.5 years. The mean MELASQOL score was 39.8±16.03 and the mean DLQI score 6.7±4.41. The MASI and MELASQOL scores showed statistically significant correlations (p<0.01, Pearson correlation=0.373). But, there was no statistically significant correlation between MASI and DLQI scores (p>0.05, Pearson correlation=0.129). Also, multiple linear regression model shows that the correlation of MASI and MELASQOL (standardized coefficient=0.367, p<0.001) is higher than the MASI and DLQI (standardized coefficient=0.139, p>0.05). Conclusion: We suggest that the MELASQOL could be more relevant and useful than DLQI when evaluating the quality of life for melasma patients. It is presumed that the MELASQOL might be helpful in guiding the patient to appropriate treatment methods and in tracking patient`s satisfaction levels.
Background: The most of typical seborrheic keratoses (SKs) can be clinically differentiated with ease from other dermatoses. However, its differential diagnosis can sometimes be difficult and recently reported cases clinically suggest that SKs with the skin biopsy result being some other diseases can bring on the need for further evaluations. Objective: The aim of this study is to examine the diagnostic yield in submitting clinically diagnosed SKs which showed single discoid lesions of the face for routine microscopic examinations. Methods: We conducted a retrospective review of cases for histological examinations with a clinical diagnosis of SKs or with a differential diagnosis that includes SKs which shows single discoid lesion of the face. A total of 94 pathology reports containing a diagnosis of SKs in the clinical information field were identified. The accuracy of the clinical diagnosis and clinic histopathological correlations were studied. Results: In this study, 45.7% of patients was clinically assumed to have SKs but turned out to be some other diseases according to the histopathology test results - a total of 19 cases (44.2%) with some considered to be precancerous (actinic keratosis 25.6%, benign lichenoid keratosis 16.3% or cancerous (basal cell carcinoma 9.3%, squamous cell carcinoma 4.7%). Conclusion: Lesions suggested to be SKs need more examinations and lesions of atypical clinical appearances which cannot completely exclude the possibility of precancerous or malignant lesions are strongly recommended for skin biopsies. (Korean J Dermatol 2013;51(7):494∼500)
Amelanotic maliganat melanoma is a comparatively rare disease. It accounts for 1.8∼8.1% of all malignant melanoma. It is sometime difficult to diagnose amelanotic malignant melanoma because there is no pigmentation, clinically. Polypoid melanoma is a variant of nodular melanoma, which in depth seldom reaches the reticular dermis. The main part of the tumor is located above the nearby epidermis, raised in the form resembling cauliflower. We report a rare case of amelanotic malignant melanoma with polypoid feature in a 78-year-old woman who presented a single bright red nodule on the left thigh.