소음인향사양위탕(少陰人香砂養胃湯)의 효능(效能)에 관(關)한 실험적(實驗的) 연구(硏究)

김경요,Kim, Kyung-Yo 사상체질의학회 1989 사상체질의학회지 Vol.1 No.1

We have studied some effects of the SOEUMIN-HYANGSAYANGYUI-TANG (S.H.Y.) on the C.N.S. and on the intestines. Several empirical remarks, depending on the different treatments, are investigated throughout this study as follows; 1) The treatment, using atropine bromide, represses the effect of the S.H.Y. on the contractive force of intestines. 2) The treatment, using pheniramine maleate, seems not be able to repress the effect of the S.H.Y. on the contractive force of intestines. 3) The treatment, using cyproheptadine, seems not be able to repress the effect of the S.H.Y. on the contractive force of intestines. 4) The analgesic effect as well as the antipyretic effect are remarked while the acetic acid is applied. 5) The suppressive action on the convulsion, induced by strychine, is not observed. However the significant effect on the convulsion induced by picrotoxin is remarked. 6) The sedactive effect of the S.H.Y., using the Rotor rod test, is not obviously observed.

청심연자탕(淸心蓮子湯)이 태음인(太陰人) 뇌경색증(腦硬塞症) 환자(患者)의 세포활성물질(細胞活性物質) 생성조절(生成調節)에 미치는 영향(影響)

김경요,노현수,Kim, Kyung-Yo,Noh, Hyun-Soo 사상체질의학회 2000 사상체질의학회지 Vol.12 No.2

Purpose : Studies on the Regulatory Effect of Cytokine Production in Taumin Patients with Cerebral Infarction by Cheongsimyeonjatang Method : ELISA(enzyme-linked immuno-sorbent assay) Result : Chungsimyeunjatang(CYT) is a prescription for the cerebral infarction (CI) patients of Taeumin according to Sasang constitution philosophy. Taeumin patients with CI were treated with CYT during the acute stage. Clinical signs of CI disappeared markedly in about two to four weeks after oral administration of CYT in all patients. The mean interleukin (IL)-2 plasma levels were slightly lower in the patients with CI than in the normal groups, whereas the mean IL-4, IL-6 and IgE levels were significantly higher in the patients. There were no significant differences in $interferon-{\gamma}$ $(IFN-{\gamma})$ levels between the groups. Serum $IFN-{\gamma}$ and IL-2 levels derived from T helper (Th)1 cells were elevated significantly in the patients with CI by CYT administration. Significant reduced plasma levels of IL-4 and IL-6 derived from Th2 cells and IgE were observed in the patients treated with CYT. During the period of CYT administration, there were no other adverse effects. The data indicate that CYT has a good CI treatment effect, and that its action may be due to regulation of cytokine Production.

("동의수세보원(東醫壽世保元)"에서 인용한 "동의보감(東醫寶鑑)"의 문장(文章)에 대한 고찰

김경요,유관석,원진희,Kim, Kyung-Yo,Yoo, Kwan-Suk,Won, Jin-Hee 사상체질의학회 2006 사상체질의학회지 Vol.18 No.3

1. Objectives This study is written to investigate the biblographical facts on the book ${\ulcorner}$Dogyi Suse Bowon${\lrcorner}$(東醫壽世保元) quoted from ${\ulcorner}Dongeuibogam{\lrcorner}$(東醫寶鑑). 2. Methods It was researched on the comparative and literal study about the relation to ${\ulcorner}$Dogyi Suse Bowon${\lrcorner}$, ${\ulcorner}Dongeuibogam{\lrcorner}$and several books quoted from ${\ulcorner}Dongeuibogam{\lrcorner}$. 3. Results and Conclusions In this study, We found out${\ulcorner}$Dogyi Suse Bowon${\lrcorner}$has several wrong quoted expressions. 1) There are 22 wrong expressions of quoted book 2) There are 6 wrong expressions of writer 3) There are 6 wrong expressions of contents

형방지황탕(荊防地黃湯) 전탕액(煎湯液)이 산소자유기로 손상된 배양(培養) 해마신경세포(海馬神經細胞)에 미치는 영향

김경요,배영춘,노현수,김종관,한병삼,권덕윤,최용석,Kim, Kyung-Yo,Bae, Young-Chun,Lo, Hyun-Soo,Kim, Jong-Gwan,Han, Byung-Sam,Gwon, Duk-Yun,Choi, Yong-Seok 사상체질의학회 2003 사상체질의학회지 Vol.15 No.2

The purpose of this study is to examine the toxic effects caused by glucose oxidase (GO) and the effects of Hyungbangjihwangtang (HJT) water extracts on the treatment of the toxic effects. For this purpose, experiments with the cultured hippocampal cells from new born mice were done. The results of these experiments were as follows. 1. GO decreased the survival rate of the cultured cells on MTT assay and NR assay. 2. HJT has the efficacy of decreasing the lipid peroxidation. 3. HJT has the efficacy of increasing the amount of neurofilaments. 4. HJT has the efficacy of decreasing the activation of protein kinase C(PKC). From the above results, it is concluded that HJT has marked efficacy as a treatment for the damages caused by the GO-mediated oxidative stress. Further clinical study of this pharmacological effects of H]T should be completed.

사상(四象) 체질별(體質別) 약재(藥材) 분류(分類) 관한 연구(硏究)(태음인(太陰人) 및 태양인편(太陽人編)

김경요,김종열,Kim, Kyung-Yo,Kim, Jong-Yol 사상체질의학회 2002 사상체질의학회지 Vol.14 No.1

We analyzed 44 and 16 types of herbal medicines for Taeumin and Taeyangin, clinically applied in Dongyisoosebowon. In order to discover the standard of herbal classification for the Sasang constitutions, four concepts of Sasang Medicine were applied. These included 'Sadangron (theory of four groups)', 'Seungganggaehap (ascending-descending and gathering-dispersing)', 'Pyorihanyoul (exterior-interior and hot-cold)',and 'Hyungchiaekmi (fragrance, smell, bodily fluid and taste)'. According to these analyzing methods of herbal properties, we have reached the following conclusions: Herbal medicines for 'Taeumin' are characterized by opening energetics that reinforce dispersing Qi. The 'Exterior cold disease' is treated with herbs that ventilate the lungs and disperse dampness in three ways: by moistening the lungs, by releasing exterior, and by resolving dampness. The 'Interior heat disease' is treated with herbs that clear the liver and disperse heat in two ways. One by clearing liver heat through dispersing damp-heat of the small intestine and the other by opening orifices. Herbal medicines for Taeyangin are characterized by those that gather energy inward. They include herbs that treat beriberi, dystrophy of the extremities and vomiting, as well as, fish, shellfish, fruits and vegetable.

태음인(太陰人) 남학생(男學生)의 혈액변화(血液變化)에 대한 연구(硏究)

김경요,한종현,홍순용,Kim, Kyung-Yo,Han, Jong-Hyeon,Hong, Sun-Yong 사상체질의학회 1991 사상체질의학회지 Vol.3 No.1

Comparative blood analysis was carried out to investigate the change of blood constituent in TAE-EUM-IN group and control group. RBC, WBC, hemoglobin, hematocrit, total protein, triglyceride, phospholipid, total cholesterol, LDL-cholesterol, HDL-cholesterol, BUN, creatinine, ACTH, cortisol and prostaglandin E and $F_2{\alpha}$ were measured. And the following results were obtained: 1. In the change of blood cell, the value of hematocrit showed significant difference, while that of RBC, WBC and himoglobin didn't. 2. In the change of protein, the value of total protein showed significant difference, but that of albumin didn't. 3. In the change of lipid and cholesterol in serum, the value of triglyceride, phospholipid, total cholesterol and LDL-cholesterol indicated significant difference, while that of HDL-cholesterol indicated significant difference, while that of HDL-cholesterol didn't. 4. The value of BUN in serum represented significant difference, but that of creatinine didn't. 5. The value of cortisol in plasma showed significant difference, but that of ACTH didn't. 6. The value of prostaglandin E and $F_2{\alpha}$ in plasma showed significant difference. These results suggest that investigation on hormones and blood constituents enables objectification in differentiation of four types of physical constitution.

양격산화탕(凉膈散火湯)이 소양인(少陽人) 뇌경색증(腦硬塞症) 환자(患者)의 세포활성물질(細胞活性物質) 생성조절(生成調節)에 미치는 영향(影響)

김경요,권덕윤,Kim, Kyung-Yo,Kweon, Deog-Yun 사상체질의학회 2000 사상체질의학회지 Vol.12 No.2

1. Purpose This studies the regulatory effect of cytokine production in Soyangin patients with cerebral infarction by Yangkyuksanhwatang. 2 Method ELISA 3. Result & Conclusion Yangkyuksanhwatang(YST) is a prescription for the cerebral infarction (CI) patients of Soyangin according to Sasang constitution philosophy. Soyangin patients with CI were treated with YST during the acute stage. Clinical signs of CI disappeared markedly in about 2 to 4 weeks after oral administration of YST in all patients. The mean interleukin (IL)-2 plasma levels were slightly lower in the patients with CI than in the normal groups, whereas the mean IL-4, IL-6 and IgE levels were significantly higher in the patients. There were no significant differences in interferon- ${\gamma}$ (IFN- ${\gamma}$ ) levels between the groups. Serum IFN- ${\gamma}$ and IL-2 levels derived from T helper (Th)1 cells were elevated significantly in the patients with CI by YST administration. Significant reduced plasma levels of IL-4 and IL-6 derived from Th2 cells and IgE were observed in the patients treated with YST. During the period of YST administration, there were no other adverse effects. The data indicate that YST has a good CI treatment effect, and that its action may be due to regulation of cytokine production.

"사상의학초본권(四象醫學草本卷)"과 "동의수세보원(東醫壽世保元)" 초판본(初版本)의 비교를 통한 사상 방제의 변천 과정에 대한 연구

김경요,옥윤영,Kim, Kyung-Yo,Ok, Yun-Young 사상체질의학회 2000 사상체질의학회지 Vol.12 No.2

Purpose This study is intended to catch the expansion of theory of Sasang Constitutional Medicine through comparison prescription of Sasang-Yihak-Chobonguen with prescription of Dongyi-Soose-Bowon Method I studied the archive of prescription and medicines concerned in the Sasang-Yihak- Chobonguen with Dongyi-Soose-Bowon Result and conclusion 1. The base of theory on prescription of Sasang-Yihak-Chobonguen is based on Naesang -oigam theory but the base of theory on prescription of Dongyi-Soose-Bowon is based on Pyoribyung theory of Sasang constitutional Medicine. 2. Medicines are confused in prescription of Sasang-Yihak-Chobonguen but medicines are not confused in prescription.

태(太)·소음인(少陰人), 소양인(少陽人)의 처방(處方)이 Gold thioglucose로 유발(誘發)된 백서(白鼠)의 비만병(肥滿病)에 미치는 효과(效果)

김경요,Kim, Kyung-Yo 사상체질의학회 1996 사상체질의학회지 Vol.8 No.1

비만(肥滿)은 일반적으로 칼로리 섭취가 신체 활동과 성장에 필요한 에너지 소비량을 초과하여 지방질이 지방조직에 과잉 축척된 열량 불균형 상태로 표현하며, 표준체중의 10% 이상율 과체중이라 하고 20%이상 초과된 경우를 비만이라고 부르고 있다. 이러한 과잉 체지방은 지방세포의 크기가 변함으로써 과잉으로 체내에 축척되게 되고, 극히 심한 경우에는 지방세포의 수가 증가되기도 한다. 아울러 비만은 서구화된 사회에서 가장 혼한 영양 불량 문제이고 빠른 속도로 중가하고 있다. 비만의 원인을 나누어 보면 일반적으로 외적 원인과 내적 원인에 의해 일어나는 것으로 구분한다. 외적 원인으로는 음식의 과잉 섭취와 운동 부족 등이 있으며 내적 원인으로는 유전적 요인, 병적인 요인(시상하부병변, 갑상선 이상, 뇌하수체전엽 이상, 다른 질환의 2차적 합병증)등이 있다. 이 밖에 심리적 요인 등이 있다고 보기도 한다. 비만자의 사망율을 살펴보면, 보통 사람보다 분명히 높게 나타나고 있으며, 이것은 비만자의 심장질환, 동맥경화, 고혈압, 당뇨병 등의 성인질환 유병율이 높기 때문이며, 이로 인해 미국 및 선진 여러 나라에서 비만에 대한 대책이 사회 문제화되고 있는 것을 볼 수 있다. 동양의학에서는 비만을 비(肥), 비인(肥人), 비귀인(肥貴人), 비부성(肥膚盛), 비반 등으로 표현하였고 그 형상에 대하서는 "황제내경(黃帝內經)"에 "연질장대(年質壯大) 혈기충잉(血氣充孕) 부혁견고(膚革堅固)${\cdots}$ 비인지(肥人地)", "괵육견 피수자비(皮綬者肥)"라고 쓰여져 있다. 동양의학에서 비만의 현인에 대하여 고찰해 보연 "황채내경"에 "수식감미(數食甘味)", "고취지질(高聚之疾)", "탐어취여(貪於取與)"라고 쓰여져 있으며, 주로 고량후미(膏梁厚味)한 음식(飮食)의 탐식(貪食), 습담(濕痰), 기허(氣虛)및 간신양허(肝腎陽虛), 비토처약(脾土處弱), 비위적열(脾胃積熱), 비신양허(脾腎陽虛)와 같은 오장육부(五臟六腑)의 기능 조화가 상실돼 비습(肥濕), 즉 지방과 수분이 과잉 축적되기 때문이라고 하였다. 비만의 치법으로는 약물요법 이외에도 한방적 치료 방법으로는 청구요법, 이침요법, 기공과 수기, 운동요법, 절식요법등이 있다. 이중 절식요법, 운동요법은 양한방에서 가장 바람직한 치료법이나 지속적인 치료를 할 수 없다는 어려운 점이 있다. 한의학적 치료의 효과는 식욕 억제와 함께 식사량을 줄이는 데서 오는 심한 공복감, 무기력, 어지러움, 구역감, 변비 등을 최소화하는 것이다, 특히 무기력, 두통, 위장장애등 부작용을 줄여 주는 일에 초점을 두고 있다. 아울러 오장육부의 기능을 활성화하고 인체를 보강하여 식사 및 체중 감량에 따르는 만성질환의 발생이나 저항력 감퇴 등을 막아 준다. 최근 들어 비만에 대한 한의학적 연구들이 많이 시행되고 있으나 사상처방을 이용한 연구 및 실험은 거의 없는 실정이기에, 사상처방이 비만의 치료에 효과가 있으리라 생각하고 본 실험에 착수하게 되었다. 본 실험에 사용된 사상처방은 모두 이제마의 신정방(新定方)으로서 "동의수세보원"에 기재되어 있는 것으로 태음인(太陰人) 태음조위탕(太陰調胃湯), 소음인(少陰人) 십이미관중탕(十二味寬中湯), 소양인(少陽人) 양격산화탕(凉膈散火湯)을 선택하였다. 태음인 태음조위탕은 태음인 표병증에서 식후비만, 퇴각무력(腿脚無力) 등에 사용되며 여러 문헌에서 중풍허증(中風虛證), 식후도포(食後倒 It is researched to elucidate the effects of Taeumjowuitang(TE,太陰調胃湯), Sibimikwanjungtang(SE, 十二味寬中湯) and Yangkeogsanwhatang(SY,凉膈散火湯) on the obesity induced by gold thioglucose and the differentiation and growth of preadipocyte 3T3-L1 in the mouse. The result were as follows: 1. TE,SE and SY extracts improved the blood level of transaminase in the obese mouse induced by gold thioglucose. 2. TE,SE and SY extracts inhibited the increase of liver fat and body fat in the obese mouse induced by gold thioglucose. 3. TE,SE and SY extracts inhibited the increase of body weight in the obese mouse induced by gold thioglucose. 4. TE,SE and SY extracts inhibited the growth of undifferentiate preadipocyte 3T3-L1. 5. TE,SE and SY extracts showed inhibitory effect on the differentiation of preadipocyte 3T3-L1. The above results suggest that the TE,SE and SY extracts may be used on the obesity induced by the overgrowth and differentiation of adipocyte, and the accumulation of fat in liver and body.

사상(四象) 체질별(體質別) 약재(藥材) 분류(分類)에 관한 연구(硏究) (소양인편(少陽人編))

김종열,김경요,Kim, Jong-yol,Kim, Kyung-yo 사상체질의학회 2001 사상체질의학회지 Vol.13 No.3

We analyzed 45 types of herbal medicines for Soyangin, clinically applied in Dongyisoosebowon. In order to discover the standard of herbal classification for the Sasang constitutions, four concepts of Sasang Medicine were applied. These included 'Sadangron(theory of four groups)', 'Seungganggaehap(ascending-descending and gathering-dispersing)', 'Pyorihanyoul(exterior-interior and hot-cold)', and 'Hyungchiaekmi(fragrance, smell, bodily fluid and taste)'. According to these analyzing methods of herbal properties, we have reached the following conclusions: Herbal medicines for 'Soyangin' are characterized by descending energetics that reinforce the Yin Qi. The 'Exterior cold disease' is treated with herbs that descend the "Exterior Yin" in five ways: by releasing exterior, by resolving dampness, by clearing and transforming heat phlegm, by clearing heat, and by settling and calming the spirit. The 'Interior heat disease' is treated with herbs that raise the "Interior Yang" in three ways: by tonifying kidney Yin, by clearing heat, and by clearing heat and purging.