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광두근이 백서 중대뇌동맥 폐쇄에 의한 국소뇌허혈손상에 미치는 효과
이현삼,정혁상,강철훈,손낙원 대한한의학회 2000 대한한의학회지 Vol.21 No.2
Objective : This research was performed to investigate protective effects of Sophora subprostrata, against ischemic brain damage after a middle cerebral artery(MCA) occlusion. The effect was estimated using histological test, neurobehavioural test, and biochemical test. Methods : Rats(Sprague-Dawley) were divided into four groups: Sham operated group, MCA occluded group, Sophora subprostrata administrated group after MCA occlusion, and Normal group. The MCA was occluded by intraluminal method. Sophora subprostrata was administrated orally twice(l and 4 hours) after middle cerebral artery occlusion. The neurobeavioural test was performed at 3 hours, 6 hours, 9 hours and 24 hours after the surgery by posture reflex test and swimming behavioural test. All groups were sacrificed at 24 hours after the surgery. The brain tissue was stained with 2% triphenyl tetrazolium chioride(TTC) or 1 % cresyl violet solution, to examine effect of Sophora subprostrata on ischemic brain tissue. The blood samples were obtained from the heart of rats. Tumor necrosis factor-a level was measured from sera using Enzyme-Linked Immunoabsorbent Assay(ELISA). Results : The results showed that (1) Sophora subprostrata reduced infarct size and total infarct volume by 54.8% compared to the control group, (2) that neuronal death, which was shown by decrease in cell number and size, was attenuated significantly in the boundary area of the infarction, (3) that serum $TNF-{\alpha}$ㆍlevel was reduced significantly, and finally, there was significant recovery of motor deficit at 3 hours after MCA occluded by Swimming behavioural test. Conclusions :In conclusion, Sophora subprostrata has protective effects against ischemic brain damage at the early stage of ischemia.
이현삼 ( Hyun Sam Lee ),이훈 ( Hoon Lee ),손인미 ( In Mi Sohn ),이동주 ( Dong Joo Lee ) 대한면역약침학회 2014 대한면역약침학회지 Vol.3 No.2
Herpes zoster (Shingles) is a disease since the Varicella-zoster virus (VZV) had been dormant in the sensory dorsal root ganglion, reactivated in the immunocompromised status. Main symptoms are the herpes rash of the skin accompanied by unilateral pain. Immuno-Yakchim is one of the Korean medicine therapy for treating a disease through the Su-Seung-Hwa-Gang & Pyo-Li-Tong-Ki by the method of injecting purified herbal extract at the meridian points. We analyzed the clinical cases to determine the therapeutic effect of immuno-Yakchim for Herpes zoster. In conclusion, treatment of immuno-Yakchim for acute stage of herpes zoster might be effective, and tendency of suppressing the transition to postherpetic neuralgia.