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홍경천(紅景天)추출물(KH101)이 강제유영 흰쥐의 피로회복에 미치는 영향
정혁상,김은영,심은섭,이현삼,문은정,김진화,김선여,손영주,손낙원,Jung, Hyuk-Sang,Kim, Eun-Young,Shim, Eun-Sheb,Lee, Hyun-Sam,Moon, Eun-Jung,Jin, Zhen-Hua,Kim, Sun-Yeou,Sohn, Young-Joo,Sohn, Nak-Won 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Objectives : Rhodiola rosea has been used in herbal medicine to treat various conditions, such as antimelancholia, antifatigue, improvement of work competence and prevention of altitude sickness. In this study, we investigated effects of Rhodiola rosea extract (KH101) on fatigue in forced swimming rats. Methods : Sprague-Dawley rats were induced with fatigue by forced swimming, then rats in each group were treated with KH101. We observed changes of glucose, LDH and cortisol in serum and LDH, glycogen, hexokinase, citrate synthase MDH, SDH and CK in muscle. Results : Obtained results were as follows: 1. Continuance times of exercise significantly increased in all groups at day 1, in the 50 mg/kg concentration group at day 2, in all groups at day 3 and in the 50 mg/kg conc. group at day 4. 2. In serum, glucose significantly decreased in all concentration groups. 3. In the soleus muscle, LDH significantly decreased in the 50 mg/kg concentration group. HK significantly decreased in the 100 mg/kg conc. group. SDH significantly increased in the 100 mg/kg conc. MDH were significantly decreased in all conc. groups. 4. In the gastrocnemius muscle, HK significantly decreased in all concentration groups, while MDH significantly increased all conc. groups. Conclusions : It is concluded that the KH101 has and anti-fatigue effect in rats. Additional studies are needed to find the mechanism of the association between each single herb.
정혁상,Jung, Hyuk-Sang 한국터널지하공간학회 2016 한국터널지하공간학회논문집 Vol.18 No.5
본 논문은 비파괴 기법을 활용한 격자지보재의 품질평가 기법에 대한 내용을 다루었다. 일반적인 격자지보재의 성능평가는 강재의 인장강도시험과 육안조사로 이루어진다. 강재의 인장강도시험은 현장에 반입되는 격자지보의 시편을 확보하여 수행하게 되는데 이때 시편 확보를 위해 격자지보재를 훼손시켜야하는 단점을 가지고 있고 대부분의 현장에서는 인장강도시험기를 보유하고 있지 않아 시험인증기관에 의뢰해야하는 불편함을 가지고 있다. 또한 강재 생산시 발행된 성적서(Mile sheet)로 대체하기도 하나 이는 신뢰성이 결여될 수 밖에 없다. 더욱이 현장에서의 육안조사는 신뢰성이 결여되는 문제점을 가지고 있기 때문에 현장에서 자재의 훼손없이, 쉽고 빠르게 격자지보재의 품질을 평가할 수 있는 방법이 필요하게 되었다. 따라서 본 연구에서는 동일 시편에 대한 인장강도시험의 항복강도와 계장화압입시험의 항복강도를 비교 분석하여 비파괴시험법의 적용성을 분석하였다. 시험결과 계장 화압입시험은 95%이상의 정밀도를 보였으며 현장에서 성능평가가 가능한 계장화압입시험에 의한 품질평가기법을 제안하고자 한다. This paper dealt with contents of the quality evaluation method of lattice girder utilizing non-destructive method. Quality evaluation of ordinary lattice girder is performed through the tensile strength test of structural steel and visual inspection. The tensile strength test of structural steel is performed by collecting samples of lattice girder brought into the site, during which lattice girder must be damaged to obtain sample. In addition to such disadvantage, tensile strength tester is not available at the site in most cases, requiring an inconvenient service from test certification agency. In addition, it is substituted by mile sheet issued during the production of structural steel, which inevitably lacks reliability. Furthermore, visual inspection at the site entails a problem of lack of reliability, thereby requiring a method of easily and quickly evaluating the quality of lattice girder without damaging the material. Accordingly, this study comparatively analyzed the yield strength of tensile strength test and the yield strength of instrumented indentation test with same sample. The test results ensured over 95% precision level for the instrumented indentation test, based on which a quality evaluation method based on instrumented indentation test that allowed onsite direct quality evaluation is proposed.
뇌해마의 장기양 조직배양을 이용한 한약물의 뇌신경세포손상 보호효능 연구
정혁상,손낙원,이원철,Jung, Hyuk-Sang,Sohn, Nak-Won,Lee, Won-Chul 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3
Objectives : For the screening of neuroprotective effects of medicinal herbs, the complex system of animal models suffer some disadvantages in controlling critical parameters such as blood pressure and body temperature. Additionally, application of drugs to the appropriate brain area sometimes is difficult, due to poor permeability though the blood brain barrier, and so potential protective effects might be masked. Methods : Organotypic hippocampal slice culture (OHSC) method has the advantages of being relatively easy to prepare and of maintaining the general structure, including tissue integrity and the connections between cells. Drugs can easily be applied and neuronal damage can easily be quantified by using tissues and culture media. This study demonstrates neuroprotective effects of Puerariae radix (葛根, PR), Salviae miltiorrhizae radix (丹蔘, SR), Rhei rhizoma (大黃, RR), and Bupleuri radix (柴胡, BR). These were screenedand compared to MK-801, antagonist of NMDA receptors, by using OHSC of 1 week-old Sprague-Dawley rats. Oxygen/glucose deprivation (OGD) were conducted in an anaerobic chamber $(85%\;N_2,\;10%\;CO_2\;and\;5%\;H_2)$ in a deoxygenated glucose-free medium for 60 minutes. Water extracts of each herbs were treated to culture media with $5\;{\mu}g/ml$ for 48 hours. Results : Neuronal cell death in the cultures was monitored by densitometric measurements of the cellular uptake of propidium iodide (PI). PI fluorescence images were obtained at 48 hours after the OGD and medicinal herb treatment. Also TUNEL-positive cells in the CAI and DG regions and LDH concentrations in culture media were measured at 48 hours after the OGD. According to measured data, MK-801, PR, SR and BR demonstrated significant neuroprotective effect against excessive neuronal cell death and apoptosis induced by the OGD insult. Especially, PR revealed similar neuroprotective effect to MK-801 and RR demonstrated weak neuroprotective effect. Conclusions : These results suggest that OHSC can be a suitable method for screening of neuroprotective effects of medicinal herbs. (This work was supported by the research program of Dongguk University and Grant 01-PJ9-PG1-01CO03-0003 from Ministry of Health & Welfare.)
정혁상,신영완,송기일,신종호,Jung, Hyuk-Sang,Shin, Young-Wan,Song, Ki-Il,Shin, Jong-Ho 한국터널지하공간학회 2016 한국터널지하공간학회논문집 Vol.18 No.2
본 논문은 격자지보재의 규격자재와 비규격자재의 성능평가에 대한 내용을 다루었다. 격자보재는 강봉으로 제작된 아치형의 터널지보공을 말하며 터널 굴착시 지반의 변형을 최대로 억제하여 터널의 안정성을 확보하기 위하여 사용되어지는 지보재이다. 이런 격자지보재의 성능평가는 휨강도시험과 인장강도시험을 통해 평가할 수 있으며 터널표준시방서에서는 항복강도 500MPa 이상인 용접용 강재를 사용도록 규정하고 있다. 그러나 저품질의 강재가 사용될 경우 현장에서 규격자재와 비규격자재를 육안으로 구분하기 어렵게 되었다. 따라서 본 논문에서는 격자지보재의 규격자재와 비규격자재에 대한 성능평가를 실시하여 비규격자재의 항복강도 저하의 문제점을 분석하였다. This paper dealt with contents on the performance evaluation of standardized steel and non-standardized steel of lattice girder. Lattice girder is arch type tunnel supports made of structural steel bar and it is girder used to ensure the stability of tunnel by suppressing any transformation of ground as much as possible during tunnel excavation. The performance evaluation of lattice girder can be conducted through bending strength test, tensile strength test and tunnel standard specification specifies that welding structural steel with over 500MPa yield strength shall be used. However, it is difficult to distinguish visually between standardized steel and non-standardized steel onsite if low-quality structural steel is used. Accordingly, this paper conducted performance evaluation of standardized steel and non-standardized steel of lattice girder to point out the issue of deteriorated yield strength of non-standardized steel, while proposed a method of verifying yield strength onsite.
정혁상(Jung Hyuk Sang),홍종욱(Hong Jong Ouk),백승인(Baeg Seung In),천병식(Chun Byung Sik) 대한토목학회 2012 대한토목학회논문집 C Vol.32 No.4
최근 도심지에서 터널이 인접하여 시공하는 사례가 흔해지면서 특수하게 신설터널과 기존터널이 교차되는 터널들에 관한 설계 및 시공에 관한 연구들이 속속들이 발표되고 있다. 터널이 상호 교차되어 시공될 경우 기존터널에 영향을 미치는 주요 인자로는 터널 간 이격거리, 상대적인 위치 관계, 신설터널의 크기, 신설터널의 시공방법 지형 및 지질조건, 기존터널 라이닝 구조와 건전도 등이 영향을 미친다고 보고되고 있다. 본 연구에서는 실내모형 실험을 통하여 신설터널 굴착에 따른 기존 터널의 종방향 침하 경향 분석 및 신설터널의 상·하 위치변동에 따른 기존터널의 종방향 침하 경향 비교·분석하였다. 또한, 교차부에서 신설터널 굴착에 따른 기존터널의 변위 분포에 관한 경향 분석 및 기존터널의 변형률 분포 경향을 분석하였다. 연구결과 신설터널이 기존터널 하부를 통과하는 경우 터널직경의 기준으로 좌우측 각각 1D 이내의 보강영역이 필요한 것으로 분석되었고, 신설터널과 기존터널의 교치부에서는 신설터널의 굴착 영향이 기존터널에 먼저 미치는 영역부터 보강을 실시하여야 할 것으로 판단된다. With the increase in infrastructure needs and tunnel construction, more complicated geometries have come to light, especially in cross tunnel design and construction. The major factors to influence existing tunnels are spacing between tunnels, relative position, size of the new tunnel, construction techniques, topographic and geologic conditions, structure, and alternative construction. In this study, settlement from an excavation for a new tunnel near an existing tunnel, settlement from a change in position of the new tunnel relative to an existing tunnel, and the distribution of deformations of the existing tunnel as a result of excavating the cross-location are analyzed through laboratory model tests. As the results, in condition of the new tunnels go through below the existing tunnel, not only analysed through the standard of the diameter of the tunnel, so it would need to set up to strengthen the field within each side of the 1D, but also determined the part of the cross in the existing and the new tunnel, should implement the reinforcement from the part of new tunnel to the existing tunneling influence of excavation.
정혁상(Hyuk Sang Jung),한진규(Jin Kyu Han),문준식(Joon Shik Moon),윤환희(Hwan Hee Yoon) 한국지반환경공학회 2017 한국지반환경공학회논문집 Vol.18 No.12
본 논문에서는 운영 중인 철도노반의 침하에 대응하고자 노반보강 재료와 공법에 대한 내용을 다루었다. 국내에서는 도시철도와 고속철도, 그리고 일반철도에 콘크리트궤도가 도입되고 있지만 최근 시공된 일부구간에서 콘크리트궤도의 노반침하가 발생되고 있고, 유지보수에 어려움을 겪고 있는 실정이다. 철도 안전운행을 위해 침하된 철도노반의 보강이 시급하지만 현재까지 운영중인 철도노반의 보강에 대한 시공사례는 전무한 상태로서 노반 보강에 어려움이 있다. 따라서 본 연구에서는 최초로 시도되는 운영 중인 철도노반을 보강하기 위해 지반보강 재료들을 통해 노반 보강의 목표성능을 선정하였고, 이에 침투성능 및 고결성 주입효과 등을 확인하여 목표성능의 만족여부를 판단하였다. 연구 결과 일반적으로 쓰이는 지반보강재료 및 공법들은 철도노반 보강의 적용을 위해 개선이 필요하다는 것이 확인되었다. This paper discusses about the reinforcement materials and construction method in order to cope with roadbed settlement in operating railway. In Korea, concrete tracks have been introduced to urban railways, high-speed railways, and general railways, but some recently constructed concrete tracks have experienced roadbed settlements. Reinforcement of the railway roadbed is urgent task for safe operation of railway, but it is difficult to reinforce the roadbed and there are no case history of reinforcing railway roadbed under an operating railroad track. Therefore, in this study, the target performance level for roadbed reinforcement was determined, and infiltration and solidity injection efficiency were investigated for selected reinforcement materials. As a result of the study, it was found that the generally used reinforcement materials and methods for geotechnical works need to be improved for applying in railway roadbed reinforcement.