지역 첨단산업정책 설계를 위한 진화론적 분석방법 : 의료기기산업을 중심으로

황인균(In-kyun Hwang) 대한지리학회 2023 대한지리학회 학술대회논문집 Vol.2023 No.06

지역 첨단산업정책 설계를 위한 지역적 차별화 및 착근 과정의 개념적 틀: 의료기기산업을 중심으로

황인균(In-Kyun Hwang) 대한지리학회 2022 대한지리학회 학술대회논문집 Vol.2022 No.6

한국 의료기기산업 발전에서 제도적 환경과의 관계 고찰

황인균 ( In-kyun Hwang ) 산업클러스터학회 2022 산업클러스터 Vol.5 No.1

이 논문은 제도적 환경과 의료기기산업의 발전과의 관계를 고찰하는데 목적이 있다. 이를 위해, 건강보험제도를 중심으로 의료기기산업은 어떠한 상호작용 과정을 거치며 발전하였는지를 살펴보았다. 그 결과는 다음과 같다. 첫째, 게임의 룰을 제공해주는 건강보험제도와 관련된 제도적 여건은 급여와 비급여로 구분되는 의료기기제품 유형에 따라 병원의 수익창출 구조에 영향을 주며 이는 다시 의료기기산업 부문별 발전에 영향을 미친다는 점이다. 둘째, 의료기기산업 부문별로 의료서비스기관의 형태에 따른 교섭력 여부가 차별적으로 나타났다는 점이다. 즉, 의료서비스 기관이 병·의원급, 대형병원급에 따라 의료기기 기업과 구매 기관의 교섭력에 영향을 미친다는 점이다. 이는 의료서비스기관에서 제품에 대한 친밀성이 부문별 성장에도 영향을 미칠 수 있다는 점이다. 셋째, 제품 간 경쟁구도와 관련된 시장진입 구조이다. 의료서비스 소비자인 국민 혹은 환자는 의료기관과의 일방적 관계에서 상호적 관계로 변화되는 흐름도 산업 부문별 성장에 영향을 줄 수 있다. The purpose of this paper is to examine the relationship between the institutional environment and the development of the medical device industry. To this end, we examined how the medical device industry developed through the process of interaction, focusing on the health insurance system. The results are as follows. First, the institutional conditions related to the health insurance system that provide rules of the game affect the hospital’s profit-generating structure according to the type of medical device product divided into salary and non-payment, which in turn affects the development of the medical device industry sector. Second, the medical device industry sector showed discriminatory bargaining power according to the type of medical service institution. In other words, medical service institutions affect the bargaining power of medical device companies and purchasing institutions depending on the level of hospitals, clinics, and large hospitals. This is that intimacy with products in medical service institutions can also affect growth by sector. Third, it is a market entry structure related to the competitive structure between products. The trend of changing from a one-sided relationship with medical institutions to a mutual relationship between the public and patients, who are consumers of medical services, can also affect the growth of each industry sector.

지역 산업클러스터 형성을 위한 제도적 역량 구축의 가능성과 한계: 춘천시 IT산업을 사례로

정성훈 ( Sung Hoon Jung ),황인균 ( In Kyun Hwang ) 한국경제지리학회 2010 한국경제지리학회지 Vol.13 No.4

이 논문은 산업 낙후지역의 제도적 역량 구축의 가능성과 한계점을 고찰하기 위해 강원도 춘천시 의 산업클러스터 정책 기획단계에서부터 현재까지의 진화과정을 종합적으로 분석하였다. 춘천시의 제도적 역량구축 과정을 살펴본 결과, IT 클러스터 기획에 대한 춘천시의 오류가 존재했으며, 비전제시자의 변화에 따른 클러스터 정책의 불일치, 지방정부지원형 IT 기업의 혁신역량 부족 등의 문제가 한계점으로 밝혀졌다. 이와 같은 한계점으로 인해, 춘천시는 IT 클러 스터 형성에 필요한 제도적 혁신역량의 축적에 성공하지 못한 것으로 나타났다. The aim of this paper is to explore opportunities and limitations of the top-down approach to build institutional performance by analyzing the process of local government-led cluster`s initiatives. In doing so, this paper investigates processes of the design and implementation of cluster`s policy as well as firms` innovative capacities. As the result, it reveals the fallacy of the local government`s policy in planning industrial clusters, the inconsistence of cluster initiatives due to changes of regional vision providers, weakness of innovative performance of IT firms supported by the local government in the region. It should be concluded that Chun-cheon City did not succeed in accumulating institutional capabilities which were crucial to implement a cluster initiative.

수출용 단감에 대한 Difenoconazole과 Thiamethoxam의 잔류특성 연구

장희라 ( Hee Ra Chang ),강혜림 ( Hae Rim Kang ),도정아 ( Jung A Do ),오재호 ( Jae Ho Oh ),황인균 ( In Kyun Hwang ),권기성 ( Ki Sung Kwon ),임무혁 ( Moo Hyeong Im ),김균 ( Kyun Kim ) 한국환경농학회 2012 한국환경농학회지 Vol.31 No.3

국내 유망 수출 식품 중 잔류농약으로 인하여 수출 장애가 있는 식품을 대상으로 문제가 되는 농약에 대해 CAC 및 수출국의 농약잔류 허용기준 제안을 위한 작물잔류 시험을 수행하였다. 대상 작물은 수출용 단감이었고, difenoconazole과 thiamethoxam을 대상으로 시험을 수행하였다. Difenoconazole의 잔류량 범위는 0.2∼0.56 mg/kg였고, thiamethoxam의 잔류량 범위는 0.08∼0.28 mg/kg으로 두 약제 모두 수확 1일차 시료부터 MRL 농도 이하로 잔류량이 감소하였다. 따라서 안전사용기준에 따라 약제를 살포하고 수확한다면 국내에 설정된 MRL 기준을 충분히 만족시키는 것으로 확인되었다. Difenoconazole의 각 포장별 반감기는 각각 13.6, 19.4, 16.3일 이었고, thiamethoxam의 각포장별 반감기는 각각 10.0, 15.3, 14.0일 이었다. Clothianidin의 잔류농도는 1개 지역에서 14, 28일 시료에서 검출되었으나, 농도는 0.03 mg/kg 이하였다. BACKGROUND: In order to elucidate residual characteristics of difenoconazole and thiamethoxam by treatment to sweet persimmons for one year and to generate the data for the maximum residue limit (MRL) establishment for those pesticides in or on sweet persimmon. METHODS AND RESULTS: Systemic fungicide difenoconazole WP (10% a.i.) and systemic insecticide thiamethoxam WG (10%ai.) were sprayed onto 12∼25-years-old sweet persimmons according to its preharvest interval (PHI), respectively, and then fresh sweet persimmons were harvested at 0, 1, 3, 7, 14, 21 days after treatment from pesticide-sprayed plots at each 3 sites. The analytical methods were evaluated to limit of quantification, linearity, specificity, reproducibility and recoveries. The crop samples were extracted with acetone and performed dichloromethane partition process. The extracted samples of difenoconazole were analyzed by GC-ECD and the thiamethoxam extracted samples were analyzed by HPLC with good sensitivity and selectivity of the method. The average recoveries of difenoconazole ranged from 87.5 to 99.5% with the percentage of coefficient variation in the range 4.1∼7.6% at three different spiking levels(0.02, 0.2 and 2.0 mg/kg). And the average recoveries of thiamethoxam and clothianidin ranged from 88.8 to 98.9% and 83.2 to 96.6% with the percentage of coefficient variation in the range 3.6∼5.0% and 3.8∼9.4% at three different spiking levels(0.02, 0.2 and 2.0 mg/kg), respectively. The residue amounts ranges of difenoconazole were 0.2∼0.56 mg/kg and the residue amount was decreased below the MRL level, 1.0 mg/kg, after 1 day harvest. The residue amounts ranges of thiamethoxam were 0.08∼0.28 mg/kg and the residue amount was decreased below the MRL level, 0.5 mg/kg, after 1 day harvest. And the residue amount of clothianidin was below then 0.03 mg/kg for only one test site of 14 and 28 day samples. CONCLUSION: As a result, the residual amounts of difenoconazole and thiamethoxam were not exceeded the MRL of established criteria for sweet persimmon. The biological half-lives of difenoconazole and thiamethoxam were 13.6, 19.4, 16.3 and 10.0, 15.3, 14.0 days at each three test sites, respectively.

다발성신경섬유종증의 유전학적 연구

황인균 대한피부과학회 1976 大韓皮膚科學會誌 Vol.14 No.4

Using a paradigm similar to the one employed by Crowe et al., this study was undertaken to determine the genetic characteristics of multiple neurofibromatosis in Korean people. Thirty three subjects were used in this study. All subjects were identified through an exarnination of the records of all patients who had visited the Department of Dermatology of Chonnam Medical University Hospital between 1967 and 1976. Relatives of subjects were examined whenever possible. The results of the study projected that the total number of persons in Chonriarn Province afflicted with multiple neurofibromatosis lies sornewhere between 880 and 16,500. Crowe estimated that between 2500 and 3300 patients could be found on Michigans lower peninsula. Sixty percent of this studys subjects presented as sporadic patients, a condition thought to be the resu.lt of a genetic mutation. They had no blood relatives who demonstrated the disease. Fifty percent of Crowes subject were found to be sporadic patients, and a similar study by a Japanese investigator revealed a sporadic patient rate of sixty percent. In this study, the rernaininp 40% of the subject group conformed to the expected genetic frequency, thus pointing toward the fact that rnultiple neurofibrornatosis is a highly penetrant autosomal dorninant disease. This was demonstrted by the fact that, of the 79 offspring bad by this group, 82 persons demonstrated multiple neurofibromatosis. This study also suggested somatic mutation in 3 of the 20 sporadic patients. Because this nutation did not occur at the germinal level, the patient is much less likely to transmit this disease to his offspring, One patient showed the usual clinical and family traits but the chromosome analysis was negative. Genetic issues associated with multiple neurofibromatosis are also discussed in this study.

DDS ( Diaminodiphenyl Sulfone ) 내성 나종형 (癩腫型) 나환자에 대한 Lamprene ( Clofazimine ) 약물효과의 세균학적 및 임상적 가치

김영표,황인균 대한피부과학회 1976 대한피부과학회지 Vol.14 No.2

While for the last thirty years Dapsone (4,4, diaminodiphenyl sulfone; DDS) has been the chemotherapeutic treatment of choice in the management of leprosy, other non-sulfone compounds have been used when patients have shown either sulfone resistance or sulfone sensitivity. Unfortunately, however, there have gradually appeared a significant number of dapsone resistant and non-sulfone resistant patients (i. e., patients resistant to the conventional chemotherapeutic management of leprosy), thus necessitating the synthesis of additional antileprotic medication. At present, it appears that Lamprene (Clofazimine) is the most adequate preparation for the treatment of sulfone and/or other anti-leprotic drug resistant cases, as well as reactive states. The work of Browne and Hogerzeil in 1962, and subsequent studies by ether workers, have demonstrated lamprenes anti-leprotic and anti-inflamatory effects. The drug has also been need successfully in the management of the reactive patient. However, as its most untoward side effect, the drug causes an unsightly darkening of the skin in those areas where the concentration of M. leprae is greatest. Because the literature provides only sparse data on the effect of lamprene on the morphological (MI) and bacteriological (BI) indices of bacteriologically open patients, the authors undertook the following study: Eighteen dapsone resistant patients, two of whom were in lepra, reaction, received a daily dose of 100mg. of lamprene during a period. ranging from 4 to 22 months. Patients were kept under close clinical observation and bacteriological samples were taken at an average of three month intervals from eight different sites on the body, All subjects were in residence at the National Leprosy Hospital of Korea on Sorok island. The study yielded the following results: 1) Within 3 to 8 months after the administration of lamprene, the MI decreas d to the base line in all patients save one. 2) In the short term administered group (less than 10 months), 6 of 1R patients showed a BI increase in inverse proportion to an MI decrease during the initial stage of lamprene administration. However, the BI began to decrease between the 4th and 5th months of treatment. Of the remaining 7 patients, all showed a decrease in both BI and MI. 3) In the long term administered group (more than 10 months), the BI, an indicat- or in the evaluation of long term administration, gradually decreased in 4 of 5 patients. In the remaining patients the BI increased. The authors regard the inverse relationship between the BI and MI as the result of the increment of bacilli secondary to the destruction of M. leprae by lamprene. That groups showed a decrease in both BI and Ml is interpreted as lamprenes biochemical intervention so as to render M. leprae more susceptible to phagocytosis. While. no ready explanation can account for the single case in which the BI increased and the MI also increased, the pos. ibility that there might be a strain of M. leprae resistant to lamprene must be ruled out. Thus, given the above results, the authors conclude that lamprene is a valuable antileprotic drug not only for DDF$gt; resistant patients but also for patients in lepra reaction. Moreover, this drug seems to find its best setting in the leprosarium where the untoward side effect of darkened skin does not in any way diminish the patients social relationships.

상염색체성 우성유전을 나타낸 ( Autosomal Dominant Inheritance ) 을 나타낸 다발성 신경섬유종증 ( Multiple Neurofibromatosis ) 의 1가족예

김영표,황인균 대한피부과학회 1976 大韓皮膚科學會誌 Vol.14 No.3

Multiple neurofibromatosis is known to be a genetic disease with the autosomal dominant inheritance pattern. In clinical practice, however, we can hardly ever find a case in which the autosomal dominant inheritance is demonstrable, because sporadic mutation is believed to cause about 50 % of the observed rnultiple neurofibromatosis cases, and because such patients show reduced fertility. The authors observed a family case in which the typical autosomal dominant inheritance could be demonstrated. Among 17 consanguinities of the 3 generations studied, 12 had developed multiple neurofibrornatosis. The presumed reason for the high incidence of the disease in the family studied is 2 fold: 1) The autosomal dominant gene responsible for the disease is highly penetrable. 2) The mutant gene responsible for the disease, for some unexplained reason, was transmitted from patient No. 1 to a.ll of her offsprings, instead of to only half of her offsprings, as would be expected.