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기능성 소화불량증에서 13C - 요소호기검사의 DOB30 와 위근위부 운동기능과의 상관관계
심상군(Sang Goon Shim),이풍렬(Poong Lyul Rhee),현재근(Jae Gun Hyun),김지은(Jee Eun Kim),성인경(In Kyung Sung),장재권(Jae Kwon Jang),류광현(Kwang Hyun Ryu),김영호(Young Ho Kim),김재준(Jae J . Kim),고광철(Kwang Cheol Koh),백승운(Seung 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Background/Aims: 13C-urea breath test (UBT) is accepted as an accurate test to detect Helicobacter pylori (H. pylori) infection. The results of UBT could be correlated with the extent of H. pylori colonization density or the severity of the gastric mucosal inflammation. We examined whether UBT values correlated with some parameters for proximal gastric motor functions in functional dyspepsia (FD). Methods: Twelve patients with FD and H. pylori infection confirmed by UBT were included. Breath samples were taken before and 30 min after 75 mg 13C-urea ingestion and analyzed by isotope mass spectrometry. The results of UBT were expressed as the difference between value at 30 min and value at baseline (DOB30). Gastric emptying scintigraphy and gastric barostat study were performed to measure the proximal gastric motor functions. Results: No significant correlation was found between DOB30 and proximal half-emptying time (r=-0.34, p=0.28), DOB30 and proximal gastric distribution of meal at 1 min images (r=0.03, p=0.93). According to the gastric barostat study, basal tone (r=0.53, p=0.07), compliance (r=-0.05, p=0.86), and gastric accommodation (r=-0.08, p=0.79) were not associated with DOB30. Conclusion: DOB30 does not correlate with proximal gastric motor parameters in patients with FD. (Korean J Gastroenterol 2001;38:405-410)