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관절염에 대한 resveratrol 적용의 치료 효과 리뷰 : 연구논문을 통한 동물 실험 고찰
현승철(Seung-Chul Hyun),권정욱(Jung-Wook Kwon),김동혁(Dong-Hyuck Kim),이의석(Eui-Seok Lee),임호경(Ho-Kyung Lim) 대한치과의사협회 2023 대한치과의사협회지 Vol.61 No.13
Temporomandibular disorders (TMD) are challenging to treat despite various existing methods. Stress on the temporo- mandibular joint (TMJ) leads to an accumulation of reactive oxygen species, promoting inflammation and cartilage degra- dation. Resveratrol, a natural polyphenol, inhibits inflammatory pathways and suppresses chondrocyte apoptosis, making it a promising candidate for TMD treatment. This review analyzes six studies with 3 kinds of animals on the intra-articular application of resveratrol for treating arthritis. This paper aims to elucidate the potential of resveratrol administrations into the articular cartilage to improve severity of arthritis, providing a foundation for future research and clinical investigations.
턱관절 장애 환자에서 턱관절 증식치료(Prolotherapy)의 효과 : 문헌고찰
권정욱(Jung-Wook Kwon),현승철(Seung-Chul Hyun),김동혁(Dong-Hyuck Kim),이의석(Eui-Seok Lee),임호경(Ho-Kyung Lim) 대한치과의사협회 2023 대한치과의사협회지 Vol.61 No.13
This paper reviewed prolotherapy as an approach to treating temporomandibular joint disorders (TMD), focusing on temporomandibular joint subluxation and hypermobility. Prolotherapy, commonly used in orthopedics, involves injecting substances like dextrose or lidocaine to promote healing in musculoskeletal conditions. Clinical studies in which this prolo- therapy was used for TMD were reviewed. Total 13 papers involving 372 patients (Male 90, Female 282) were examined, considering factors such as dextrose concentration (10%~50%), injection frequency (one to four times), injection period (one to four weeks) and injection sites. The assessment primarily focused on pain reduction and changes in maximum mouth opening after prolotherapy. In all papers, a consistent trend of pain reduction after prolotherapy was observed. Regarding maximum mouth opening, there were 6 cases of decreased range and 7 cases of increased range. With prolotherapys rec- ognition as a new medical technology for TMD, it emerges as a potential alternative treatment, highlighting its significance in the field.