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절연파괴 현상을 구동력으로 하는 마이크로젯 인젝터 개발
함휘찬(Hwi-chan Ham),김용현(Yong-hyun Ghymn),육승근(Seung-keun Yook),여재익(Jai-ick Yoh) 한국생산제조학회 2020 한국생산제조학회지 Vol.29 No.1
Drug delivery via microjets is a method that can potentially overcome the disadvantages of conventional needle injections. We implemented a microjet injection system that operates with spark-generated bubbles. The system consists of three components: a battery, power supply system, and microjet injector, which allows 10-20 discharges and microjet injections per second. In order to increase discharge efficiency, the circuit elements and electrode shapes were optimized and the flow inside the discharge chamber was operated to minimize the influence of metal colloids generated by electrode erosion. The microjet ejection was captured by a high-speed camera to correlate the energy of the spark discharge with microjet characteristics in order to make the system suitable for transdermal drug penetration.
장헌재(Hun jae Jang),함휘찬(Hwi chan Ham),여재익(Jai ick Yoh) 대한기계학회 2017 大韓機械學會論文集B Vol.41 No.7
경피를 통한 약물 전달 방식에 있어, 본 연구에서 제안하고 있는 바늘 없는 주사기 시스템은 레이저와 마이크로젯 인젝터로 구성 되어 있다. 이때 마이크로젯 인젝터의 핵심 메커니즘은 레이저 유도버블이다. 동력원으로 Nd:YAG와 Er:YAG, 두 종류의 레이저가 사용되었다. 버블의 특성을 결정짓는 레이저 변수인 펄스폭, 파장 등이 본 연구에서 고려되었다. Nd:YAG 레이저의 경우에 펄스폭이 버블의 생존 시간보다 짧기 때문에 캐비테이션에 가까운 버블을 형성하는 반면 Er:YAG 레이저의 경우에 펄스폭이 상대적으로 길고 물에서의 흡수가 잘 되기 때문에 보일링 버블이 만들게 된다. 버블 및 마이크로젯의 자세한 움직임은 초고속 카메라를 통해 촬영되었다. 이와 같은 과정을 통하여 마이크로젯의 특성이 버블에 의해 결정되는 것을 본 연구를 통해 관찰되었다. 약물 전달 성능은 기니어피그 조직에 형광물질을 침투한 결과로 부터 분석하였다. For transdermal drug delivery, needless injection system is composed of laser and microjet injector. Main mechanism of microjet injector is the laser-induced bubble. Nd:YAG and Er:YAG laser are used as a power source. Laser parameters such as pulse duration and wavelength are considered, which are core parameters to control the bubble motion. The Nd:YAG laser, pulse duration is short than bubble life time making cavitation like bubble while in Er:YAG laser, long pulse duration and high absorption in water drive bubble as a boiling bubble. Detailed motion of bubble and microjet is captured by the high speed camera. So it is observed that microjet characteristics are determined by the bubble behavior. The performance of drug delivery system is evaluated by fluorescent staining of guinea pig skin.
임동욱,최두선,김태민,박정래,박규백,함휘찬,김지훈,Lim, Dong-Wook,Choi, Doo-Sun,Kim, Tae-min,Park, Jung-Rae,Park, Kyu-Bag,Ham, Hwi-Chan,Kim, Ji-Hun 한국금형공학회 2020 한국금형공학회지 Vol.14 No.3
In the drug delivery system industry, the technology with even split injection becomes important for maximizing efficiency and minimizing the side effects. In conventional drug delivery system, infection can occur due to pain and splashing. Also, various applications are impossible due to disposable use, and it is the reason to avoid to use this system because of the complexity of the driving method. Therefore, in this study, a painless drug delivery device is developed for non-pain with electrical insulation breakdown method. Finite elements analysis was used to evaluate the ejection characteristics of drugs according to the shape of the micro ejection nozzle. The effect of the number of holes in the micro nozzle, the length of the nozzle and the inner shape of the nozzle on the drug discharge characteristics were analyzed.