http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
레이저 펄스 에너지를 이용한 무통증 마이크로젯 약물전달시스템
여재익(Jai-ick Yoh),한태희(Tae-hee Han),하정무(Jung-moo Hah) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
A laser based needle-free liquid drug injection device has been developed. A laser beam is focused inside the liquid contained in the rubber chamber of micro scale. The focused laser beam causes explosive bubble growth, and the sudden volume increase in a sealed chamber drives a microjet of liquid drug through the micronozzle, The exit diameter of a nozzle is less than 100 11m and we verify the injected microjet is fast enough to penetrate human soft tissue. In the experiment, the microjet penetrated 5% gelatin-water solution, which replicates human thrombus, and pork fat tissue.
Innovative Modeling of Explosive Shock Wave Assisted Drug Delivery
여재익(Jai-Ick Yoh),김기홍(Ki-Hong Kim),이경철(Kyung-Cheol Lee),이현희(Hyun-Hee Lee),박경진(Kyoung-Jin Park) 한국연소학회 2006 한국연소학회지 Vol.11 No.4
Recent advances in energetic materials modeling and high -resolution hydrocode simulation enable enhanced computational analysis of bio-medical treatments that utilize high-pressure shock waves. Of particular interest is in designing devices that use such technology in medical treatments. For example, the generated micro shock waves with peak pressure on orders of 10 ㎬ can be used for treatments such as kidney stone removal, trans-dermal micro-particle delivery, and cancer cell removal. In this work, we present a new computational methodology for applying the high explosive dynamics to bio-medical treatments by making use of high pressure shock physics and multi-material wave interactions. The preliminary calculations conducted by the in-house code, GIBBS2D, captures various features that are observed from the actual experiments under the similar test conditions. We expect to gain novel insights in applying explosive shock wave physics to the bio-medical science involving drug injection. Our forthcoming papers will illustrate the quantitative comparison of the modeled results against the experimental data.
여재익(Jai-ick Yoh),김기홍(Ki-Hong Kim),이경철(Kyung-Cheol Lee),이현희(Hyun-Hee Lee),박경진(Kyoung-Jin Park) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
??Recent advances in energetic materials modeling and high-resolution hydrocode simulation enable enhanced computational analysis of bio-medical treatments that utilize high-pressure shock waves. Of particular interest is in designing devices that use such technology in medical treatments. For example, the generated micro shock waves with peak pressure on orders of 10 ㎬ can be used for treatments such as kidney stone removal, trans-dermal micro-particle delivery, and cancer cell removal.<br/> ??In this work, we present a new computational methodology for applying the high explosive dynamics to bio-medical treatments by making use of high pressure shock physics and multi-material wave interactions. The preliminary calculations conducted by the in-house code, GIBBS2D, captures various features that are observed from the actual experiments under the similar test conditions. We expect to gain novel insights in applying explosive shock wave physics to the bio-medical science involving drug injection. Our forthcoming papers will illustrate the quantitative comparison of the modeled results against the experimental data.
여재익(Jai-ick Yoh) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5
We present two-dimensional models for two HMX-based explosives. The models are constructed based on measurements of thermal and mechanical properties along with small scale thermal explosion measurements obtained at the Lawrence Livermore National Laboratory. Confined high explosives (HE's) are heated at a rate of 1 C per hour until an explosion is observed. The heating, ignition, and deflagration phases are modeled using an Arbitrarily Lagrangian-Eulerian code that can handle a wide range of time scales that vary from a structural to a dynamic hydro time scale. During the pre-ignition phase, quasi-static mechanics and diffusive thermal transfer from a heat source to the HE are coupled with the finite chemical reactions that include both endothermic and exothermic processes. Once the HE ignites, a hydro dynamic calculation is performed as a burn front propagates through the HE in a level-set framework. The simulated dynamic response of HMX-based explosives is compared to measurements in large scale thermal explosion tests.
여재익(Jai-ick Yoh) 한국항공우주학회 2009 韓國航空宇宙學會誌 Vol.37 No.1
정상파 시스템의 구조는 발열반응으로 상변화를 하는 물질의 연속방정식에 의해 타당성을 검증받는다. 1차원 연속체 충격 구조 분석에서의 이론적 배경을 기반으로, 상변화 현상과 관련된 파의 마이크로 두께를 산출하였다. 상변화를 하는 물질로써, n-heptane은 탄화수소 연료의 증발과 응축 분석에 사용하였고, HMX은 고체 로켓 연료의 용융과 응고 분석에 사용하였다. n-heptane의 증발-응축 변의 산출 두께는 10?²마이크론 차수이고, 반면에 HMX의 용융-응고 변의 산출 두께는 1 마이크론 차수 이다. 소개된 상변 두께 산출 이론은 실험적으로 얻을 수 없는 방대한 범위의 에너지 물질까지 계산범위를 확장시킬 수 있다. The structure of steady wave system is considered which is admitted by the continuum equations for materials that undergo phase transformations with exothermic chemical reaction. With its theoretical basis in one-dimensional continuum shock structure analysis, the present approach estimates the micro-width of waves associated with phase transformation phenomena. n-heptane is selected as the hydrocarbon fuel for evaporation and condensation analysis while HMX is used for melting and freezing analysis of solid rocket propellant. The estimated thickness of evaporation - condensation front of n-heptane is on the order of 10?²micron while the HMX melting - freezing front thickness is estimated at 1 micron.
Innovative Modeling of Explosive Shock Wave Assisted Drug Delivery
Jai-Ick Yoh(여재익),Ki-Hong Kim(김기홍),Kyung-Cheol Lee(이경철),Hyun-Hee Lee(이현희),Kyoung-Jin Park(박경진) 한국연소학회 2006 KOSCOSYMPOSIUM논문집 Vol.- No.-
Recent advances in energetic materials modeling and high-resolution hydroeode simulation enable enhanced computational analysis of bio-medical treatments that utilize high-pressure shock waves. Of particular interest is in designing devices that use such technology in medical treatments. For example, the generated micro shock waves with peak pressure on orders of 10 ㎬ can be used fur treatments such as kidney stone removal, trans-dermal micro-particle delivery, and cancer cell removal. In this work, we present a new computational methodology for applying the high explosive dynamics to bio-medical treatments by making use of high pressure shock physics and multi-material wave interactions. The preliminary calculations conducted by the in-house code, GIBBS2D, captures various features that are observed from the actual experiments under the similar test conditions. We expect to gain novel insights in applying explosive shock wave physics to the bio-medical science involving drug injection. Our forthcoming papers will illustrate the quantitative comparison of the modeled results against the experimental data.
레이저 펄스 에너지를 이용한 무통증 마이크로젯 약물전달시스템
여재익(Jai-ick Yoh),한태희(Tae-hee Han),하정무(Jung-moo Hah) 대한기계학회 2011 大韓機械學會論文集B Vol.35 No.5
레이저 기반의 무바늘 액체 약물전달장치는 계속해서 개발되어왔다. 레이저 빔이 고무 챔버 내부의 액체에 모이게 된다. 초점이 맞춰진 레이저 빔은 공기방울을 생성시키고 급격히 팽창하게 된다. 밀봉된 챔버 안쪽에서의 급격한 부피변화는 액체약물을 마이크로 노즐을 통해 빠르게 밀어내어 마이크로 약물젯을 생성한다. 노즐의 출구지름은 100 ㎛ 이하이며 본 연구팀은 생성된 마이크로 약물젯의 속도가 인체의 연조직으로 침투시키기에 충분함을 확인하였다. 이 실험에서는 사람의 혈전을 모사한 무게 비 5%의 젤라틴 수용액을 냉각시킨 샘플과 돼지 지방층을 사용하여 침투실험을 수행하였다. We have developed a laser-based needle-free liquid drug-injection device. A laser beam is focused inside the liquid contained in the rubber chamber of a micro-scale. The focused laser beam causes explosive bubble growth, and the sudden volume increase in a sealed chamber drives a microjet of liquid drug through the micronozzle. The exit diameter of a nozzle is less than 100 ㎛, and we verify that the injected microjet is fast enough to penetrate soft human tissue. In the experiment, the microjet penetrated a 5% gelatin-water solution that replicates the human thrombus and pork-fat tissue.