본태성 고혈압에서의 혈중 Atrial Natriuretic Peptide 농도와 Renin - Aldosterone 계의 상관관계에 대한 연구

신현호(Hyun Ho Shin),박원근(Won Kun Park),한인권(In Kwon Han),김은주(Eun Joo Kim),김선우(Sun Woo Kim),송정상(Jung Sang Song),배종하(Jong Hoa Bae),최영길(Young Kil Choi) 대한내과학회 1987 대한내과학회지 Vol.32 No.6

N/A Atrial Natriuretic Peptide (ANP) has been shown to posseses a variety of important biologic activities, in- cluding natriuresis, relaxation of vascular smooth muscle, and reduction in aldosterone secretion. This raises the possibility that ANP may play a part in the regulation of volume homeostasis and may be involved in the pathogenesis of essential hypertension. We investigated the relationship of ANP and reninaldosterone system in 12 normal subjects and 24 patients with essential hypertension. The results were as follows; 1) Plasma levels of ANP in patients with essential hypertension were significantly higher than in normotensive controls (131.1±21.7pg/ml VS 102.3±17.4 pg/ml). 2) There were no significant difference in plasma renin activity or aldosterone levels between normotensive and hypertensive subjects. 3) The patients with low renin essential hypertension had a tendency of increased ANP concentration, compared with high renin hypertension patients. 4) Plasma levels of ANP were positively and significantly correlated with blood pressure (Systolic r=0.38, p<0.05; diastolic r=0.49, p<0.005). These results suggests that increased secretion of ANP in essential hypertension may be a compensatory response to a diminished capacity for sodium excretion.

흰쥐에서 난소제거술로 유발시킨 골다공증에 유효한 기능성성분을 배합한 P 식이의 효능

서지혜(Ji He Seo),임병우(Beong Ou Lim),강순아(Sun A Kang),한인권(In Kwon Han),박동기(Dong Ki Park) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1

N/A The aim of this investigation was to examine the effects of serum alkaline phosphatase, phosphorous, calcium and bone mineral density in P diet on osteoporosis induced by ovariectomy in rats. Female Sprague-Dawely 20 rats of weighting 249±29g, were divided into four groups including the sham operation groups (5 heads) and ovariectomy groups (15 heads). They were fed low calcium diets for 4 weeks after experimental operation and 12 more weeks. The experimental group received a daily administration of P diet for 4 and 8 weeks after oophorectomy. Therefore, we measured levels of calcium, alkaline phophatase (ALP), phosphorous, trabecular density of tibia, ash weights in tibia and femur. The level of serum ALP of P diet was showed a significant decrease in comparison with sham group. Calcium and phosphorous were almost not changed between three groups. The weight of tibia and femur of P diet was increased in comparison with sham group in 8 week after oophorectomy. The trabecular bone density in ovariectomy group showed significant decrease in comparison with sham. Those in P diet-treated showed significant increase in comparison with sham after oophorectomy. Accordingly to the above results, effects of the P diet on the rat osteoporosis showed a efficiency in elevation of bone density by increasing bone weight by ovariectomy. So P diet can be used for preventing and curing of the postmenopausal osteoporosis, as for it's effects, continuous clinical study is needed.

내분비학적으로 본 여성건강

한인권(In-Kwon Han) 대한여성건강학회 2000 여성건강 Vol.1 No.1

갱년기 골다공증 환자의 HRT와 Alendronate 1년 병합치료 효과

오한진(Han Jin Oh),임창훈(Chang Hun Lim),정호연(Ho Yeon Chung),한기옥(Ki Ok Han),장학철(Hak Chul Jang),윤현규(Hyun Koo Yoon),한인권(In Kwon Han) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.1

N/A Background; Rate of bone loss should be increased after menopause and then formation coupled with resoprtion also be increased. Alendronate (Fosamax ;MSD, Rahway, NJ, USA), an antiresorptive drug known to be helpful to prevent bone loss. Alendronate is one of antiresorptive drug for treatment of osteoporosis and resulted in a decrease of bone turnover, There are no available data about Korean people, So, we wanted to determine the effects of alendronate in Korean postmenopausal osteoporosis patients after 1- year treatment Subjects and Methods; We studied 42 women with postmenopausal osteoporosis (bone mineral density[BMD] T score<2.5) who visited osteoporosis clinic in Samsung Cheil Hospital from Jan. 1999 to Apr. 2000, Subjects were stratified in 2 groups. Group 1 treated with alendronate 10mg/day and estrogen, and Group 2 treated with estrogen alone. BMD at the lumbar spine were measured at baseline and 1-year after treatment. We also measured serum marker of bone formation (total alkaline phosphatase[Alk]), and marker of bone resorption (deoxypyridinoline [DPYD]) from urine at baseline, 3months and I-year after treatment. Results; The mean differences in changes of markers after 3 months and 1 year of treatment were remarked significantly (3-Month; delta Alk:-28,7±3.6%, delta DPYD:-31.0±5,4% vs 1-Year; delta Alk:-32.2±3.1%, delta DPYD:-23.0±3.5%). Markers of bone metabolism showed no significant responses between two groups at 3 months and 1year after treatment, Also, Bone mineral density at lumbar spine was significantly increased in Group treated with alendronatc and estrogen than estrogen only group (9.6±0,7% vs 5.3±0.6%, P<0,001). Conclusion; Our data showed that using alendronate with estrogen to the patients of Korean women with osteoporosis increase bone mineral density more, So, we concluded that alendronate therapy with estrogen was helpful to manage postmenopausal osteoporosis patients.

폐경 여성의 골밀도 변화를 중심으로 한 치료 방법의 비용효과적 비교

오한진 ( Han Jin Oh ),김의현 ( Ui Hyun Kim ),오장균 ( Jang Kyun Oh ),윤현구 ( Hyun Koo Yoon ),한인권 ( In Kwon Han ) 대한폐경학회 2001 대한폐경학회지 Vol.7 No.1

N/A Background : There were many strategies to treat postmenopausal women with osteoporosis. Because of bone mass measurement confirms the existence of osteoporosis and also predicts the risk of fracture, the effectiveness of the treatment should be measured by the amount of increased bone mass. Methods : 311 postmenopausal Korean women were evaluated who visited one of university hospital located in Seoul from Aug. 1997 to July 2000, with respect to markers of bone turnover and BMD at lumbar spine. Subjects were classified into 3 groups, peri-menopause, early-menopause, and late-menopause by menopausal states. To evaluate the cost-effectiveness of treatment, we compared changes of BMD after 1-year of treatment and total drug costs for 1-year among 3 groups. And also to evaluated the cost-effectiveness between groups classified by WHO criteria, we also compared changes of BMD and total drug costs after 1-year. Results : Our results showed those findings: 1. The const-effectiveness was similar among 3 groups classified by the menopausal state. 2. Among three groups classified by bone density, osteopenia group showed significantly favorable cost-effectiveness score than normal or osteoporotic group.

한국 폐경 여성에서 이중에너지 방사선 흡수 계측기 ( DEXA ) 의 요추 및 대퇴골 골밀도 표준화

최규홍(Kyu Hong Choi),한인권(In Kwon Han) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.1

N/A Objectives: Bone densitometry is a current method for evaluating skeletal status, assessing osteoporosis, and determining fracture risk. DEXA has rapidly became a dominant method for evaluating skeletal status, But the comparison of patient data among different DHXA scanners is complicated because the instruments show differences in scanner design, bone mineral calibration, and analysis algorithms, and scan site. This study was performed to establish appropriate cross-calibration parameters at the lumbar and femoral sites among two models of DEXA system from different manufacturers. Materials and Methods: In our study, 63 healthy, Korean women aged 37-81 years(mean age:57.1+7,03) were examined, Posteroanterior Lumbar spine (L2-L4) and hip measurements were obtained on a Hologic QDR 4500, and a Noland XR-36 densitometer. All subjects had no spinal deformities, osteophytes, fractures and scoliosis, bilateral hip replacements, and other conditions that could affect BMD measurements. We performed the measurement of BMD in each subject with different two scanners at two scan sites at the same time, Results: The correlations of the patients' spinal BMD(r 0.971) and femoral neck BMD(r 0.905) were excellent for each of the two scanner pairs. From the linear regression analysis of the patient data, cross calibration equations for spinal and femoral neck BMD values were derived, The BMD values at the lumbar spine and proximal femur measured using different scanner showed different proportion of diagnostic criteria in osteoporosis. Conclusion: Even though it has some limitations, the standardization approach as performed in our study may provide compatibility of DEXA results obtained on different scanners

고 Prolactin 혈증 환자의 당불내인성 ( Glucose Intolerance ) 의 기전에 관한 연구

고완(Wan Ko),이승재(Seung Jae Lee),곽진구(Jin Koo Kwark),박원근(Won Kun Park),한인권(In Kwon Han),김선우(Sun Woo Kim) 대한내과학회 1988 대한내과학회지 Vol.34 No.6

N/A Prolactin may have a diabetogenic action. But underlying mechanisms how prolactin induce changes in glucose homeostasis are unknown. To ascertain the potential contribution of altered insulin receptor to this phenomenon, we studied insulin binding to erythrocyte and internalization of insulin in 5 patients of hyperprolactinemia and 8 healthy, non-pregnant female control. The results were as follows: 1) Glucose tolerance deteriorates in hyperprolactinemic patients compaired with nofmal control. 2) Plasma insulin and c-peptide concentration after oral GTT of hyperprolactinemic patients were not different that of normal control. 3) Insulin binding to erythrocyte was lower in hyperprolactinemic patients than normal control. 4) Internalization of insulin was lower in hyperprolactinemic patients than normal cotnrol. Above data suggested that hyperprolactinemia is accompanied with significant insulin resistance which is partly due to reduced number of insulin receptor without changes of binding affinity and reduced internalization of insulin.

PCR 을 이용한 인슐린 수용체 β - 소단위의 DNA 측정에 관한 연구

최웅환(Woong Hwan Choi),유계수(Ge Soo Yoo),고근아(Keun Ah Koh),정형진(Hyung Jin Chung),김해엽(Hae Youp Kim),신현호(Hyun Ho Shin),한인권(In Kwon Han),문인걸(In Gul Moon) 대한내과학회 1991 대한내과학회지 Vol.40 No.6

N/A Insulin resistance is one of the most important mechanisms of type II diabetes, which may result from acquired or genetic abnormalities in the pathway of insulin action. As the develoment of cloning method of human insulin receptor precursor cDNA, it has become possible to investigate the insulin receptor at the genetic level. We used the modified PCR technique method that permitted us to employ small amounts of cellular RNA as the initial template to amplify the region that encodes the intracellar β-subunit of the human insulin receptor and C-terminal region of β-subunit. We think that this PCR method will facilitate a definite determination to what degree insulin resistance can be ascribed to genetic alterations in the structure of the insulin receptor molecule in type II diabetes.

Type 2 DM 환자에서 인슐린 또는 경구혈당강하제등의 치료에 의한 인슐린 내지환와 Dagradation 장애의 회복

박원근(Won Kun Park),고완(Wang Ko),최웅환(Woong Hwan Choi),한인권(In Kwon Han),김선우(Sun Woo Kim),정운원(Woon Won Jeng),문인걸(In Gul Moon) 대한내과학회 1988 대한내과학회지 Vol.35 No.4

N/A The internalization of I-insulin in human erythrocytes was studied using an acid extraction technique (pH 5.7, PBS) from 7 patients with type 11 diabetes mellitus (DM) and 14 normal subjects before and after glucose control. Insulin degradation products from 4 patients with type 11 DM and 14 normal subjects in the same period were assayed using HPLC with Sephadex G-50 column and a radioisotope detector. The maximal rates of insulin internalization (Incubation time: 4 hours, at 37°C) which were decreased before glucose control (50.25±6.99%vs 80.23±7.73%), returned toward normal levels after glucose control (89.5±5.45%). The maximal degradation products of insulin (incubation time: 4 hours, at 37°C) which were decreased before glucose control (62.25±10.50vs 87.75±6.66%), returned toward normal levels after glucose control (91.4±7.60%). These results suggest that in type 11 DM, the decreased rate of insulin internalization and degradation may be one of the contributory factors in the pathogenesis of postbinding resistance, which is reversible with insulin or sulfonylurea treatment.

NIDDM 환자에서 혈당조절 전후의 Nitrogen Balance 와 IGF - I 변화에 관한 연구

최웅환(Woong Hwan Choi),박원근(Won Kun Park),신현호(Hyun Ho Shin),한인권(In Kwon Han),김은주,김선우(Sun Woo Kim),최영길(Young Kil Choi) 대한내과학회 1987 대한내과학회지 Vol.34 No.1

N/A We studied the effect of blood sugar control in patients with NIDDM on the IGF-I level and nitrogen balance as a metabolic index. The result as follows 1) There was no difference in IGF-I level between patients with NIDDM and normal control group. (222±60ng/ml vs 221±49ng/ml, p>0.1) 2) There was a statistically significant increment in IGF-I level in the NIDDM patients who improved to positive nitrogen balance from negative nitrogen balance. (217±55ng/ml vs 285±44ng/ml, p<0.05) 3) IGF-I level was not increased in patients who did not improve to positive nitrogen balance after suger control and the patient who was prositive nitrogen blance initially. (231±63ng/m1 vs 190±52ng/ml, p>0.1) 4) IGF-I level was not increased in spite of improved nitrogen balance after sugar control in patients with under body weight. (221±68ng/ml vs 213±42ng/ml, p>0.1) These reult sugested that mornitoring of serum IGF-I level in NIDDM patients is useful marker which represent metabolic compensation with treatment of diabetes.