단기간의 고강도 저항성 트레이닝에 의한 근섬유의 MHC phenotype 변화

하재여(Ha Jae-Yeo),김효정(Kim Hyo-Jeong),김창근(Kim Chang-Keun) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.3

The purpose of this study was to examine the effect of 4 week resistance training on myosin heavy chain (MHC; Ⅰ, Ⅰ/Ⅱa, Ⅱa, Ⅱa/Ⅱx, Ⅱx, Ⅰ/Ⅱa/Ⅱx) isoforms in single muscle fiber in young men (age 21.20±2.25, n=10). Subjects were subjected to 4 weeks of isokinetic training and each training session consisted of 10 × 10 maximal 90°/s and 180°/s extension and flexion contractions using a Kin-Com isokinetic dynamometer. To maintain the effective control of the differences of training impact on individuals, the present study adopted the one-leg exercise training or within subject model. Muscle biopsies were obtained from right/left vastus lateralis before and after training. We analyzed MHC isoforms in single muscle fiber by electrophoretic analysis (100 fibers analyzed to each biopsy sample; 4,000 fibers analyzed in total). Mean MHC IIa isoforms in the trained leg were significantly increased by 10% (p<.05), whereas the number of MHC IIx isoforms was decreased by 8% (p<.01). MHC Ⅱa was significantly increrased by 5% (p<.05) in untrained leg. MHC Ⅱx and MHC Ⅰ/Ⅱa/Ⅱx were decreased by 7% (p<.05) and 1% (p<.05) respectively in untrained leg. However, MHC IIa expression in trained leg was increased by 5%(p<.05) than untrained leg. From the result of this study we confirmed 4 week of training result in significant changes in MHC isoforms in within subject resistance exercise model.

복합재활운동 프로그램이 슬관절 전치환술 노인 환자의 근력, 이동능력 및 균형감각에 미치는 영향

여효성(Yeo, Hyo-Seong),전유나(Jeon, Yu-Nah),하재여(Ha, Jae-Yeo) 한국웰니스학회 2017 한국웰니스학회지 Vol.12 No.3

이 연구는 퇴행성 관절염 환자의 슬관절 전치환술 후 저하되는 신체능력을 회복시킬 수 있는 효과적인 재활방법을 구명하고자 계획되었다 따라서 슬관절 전치환술 후 초기에 노인 여성 환자에게 복합재활운동 . 프로그램을 적용하여 하지의 근력, 이동능력, 균형감각의 변화를 확인하고자 하였다. 연구의 목적을 위해, 퇴행성 관절염을 가진 65세 이상 노인 여성 14명을 복합재활운동 집단(n=7)과 가정운동집단(n=7)으로 구분하였다. 복합재활운동 집단은 12주 동안 저항성 운동과 균형 운동을 병행하여 실시하였으며, 가정운동집단은 낮은 강도의 전통적인 재활운동을 실시하였다. 수술 전과 수술 후 12주간의 재활이 종료된 시점에 하지의 최대자발적 근 수축력, 이동 능력 그리고 균형능력을 측정하였다. 12주간의 복합재활운동을 실시한 노인 여성의 근력은 수술 전과 유의한 차이를 보이지 않았으나(p=.275), 가정운동을 실시한 집단의 근력은 수술 전에 비해 유의하게 낮았다(p=.001, -35.2%). 이와 유사하게 복합재활운동을 실시한 노인 여성의 이동능력은 수술 전과 유의한 차이를 보이지 않았지만(p=.639), 가정운동 집단에서는 수술 전에 비해 유의하게 낮았다(p=.002, -13.7%). 한편, 가정운동 집단의 균형능력은 수술 전 · 후 차이가 없었으며(p=.647), 복합재활운동집단의 균형능력은 훈련 후 수술 전에 비해 향상된 것으로 나타났다(p=.005, 12.5%). 이러한 결과들을 통해 복합재활 운동이 노인 여성 슬관절 전치환술 환자들의 신체기능 회복 및 기능개선에 긍정적인 영향을 미칠 가능성이 제안된다. The purpose of this study was to investigate the effective rehabilitation to regain physical abilities reduced after total knee arthroplasty (THA) of degenerative arthritis patients. Therefore, we applied combined rehabilitation exercise to aged female patients at early period after THA and observed the changes of lower limb muscle strength, mobility and balance. To purpose of the study, fourteen elderly female patients (age > 65yrs) undergone degenerative arthritis were assigned into combined rehabilitation exercise group (n=7) and home exercise group (n=7). Combined rehabilitation exercise group performed resistance exercise and balance exercise together and home exercise group conducted low level of traditional rehabilitation at home for 12 weeks. Maximal voluntary muscle contraction, mobility, and balance were measured before the surgery and after the 12 wk of rehabilitation. Muscle strength of combined rehabilitation exercise group was not changed (p=.275), however home exercise group showed significant lower muscle strength (p=.001, -35.2%). Likewise, in case of mobility, it was not changed in combined rehabilitation exercise group (p=.639), but reduced in home exercise group (p=.002, -13.7%). On the other hand, balance ability was not changed in home exercise group (p=.647), but significantly increased in combined exercise group after the training (p=.005, 12.5%). These results suggest that combined rehabilitation exercise may have a positive effect on recovery of physical function and ability of elderly female patients undergone THA.

필라테스 재활운동 프로그램이 만성요통 노인환자의 균형능력, 이동성 및 통증에 미치는 영향

여효성(Hyo Seong Yeo),하재여(Jae Yeo Ha) 한국발육발달학회 2019 한국발육발달학회지 Vol.27 No.2

Chronic low back pain is a major health problem worldwide, particularly in elderly population. Interventions based on exercise have been the most commonly used treatments for patients with this condition. Over the past few years, the Pilates method has been one of the most popular rehabilitation exercise programs used in clinical practice. Therefore, the purpose of this study was to confirm the effects of regular Pilates exercise on balance, mobility and pain in elderly patients with chronic low back pain. Fourteen elderly participants with chronic low back pain (age, 66.7 ± 1.4 years; height, 157.0 ± 4.1 cm; weight, 59.0 ± 4.6 kg; BMI, 23.9 ± 1.6 kg/m²) were randomly allocated to either a Pilates exercise group (EX, n=7) or a control group (CON, n=7). EX group performed exercise sessions with physiotherapy conducted over an 12-week period (3 sessions/week), while CON group attended only physiotherapy over the same period. The level of static balance, mobility and pain were measured 48-hours before and after the exercise program and compared to assess training effects. Static balance ability by MFT of EX group was significantly improved after the Pilates program (p=.003, -21%), whereas there was no change in CON group (p>.05). The MFT score was significantly lower in EX group than in CON group (p=.009, -21%). Likewise, mobility was improved by reducing TUG score in EX group (p=.001, -21%) after the program and the score was lower in EX group compared to CON group (p=.001, -17%). The level of pain was lowered both in EX group (p=.001, 42%) and CON group (p=.014, 11%), but there was no significant difference between groups (p>.05). These results provide initial evidence that regular Pilates rehabilitation exercise may enhance balance and mobility and reduce pain in elderly patients with chronic low back pain.

4주간의 βeta-alanine 보충이 등속성 및 무산소성 운동수행능력 향상에 미치는 영향

선주상(Seon Ju-Sang),손희정(Son Hee-Jung),하재여(Ha Jae-Yeo),이용우(Lee Yong-Woo),김효정(Kim Hyo-Jeong),김창근(Kim Chang-Keun) 한국체육과학회 2010 한국체육과학회지 Vol.19 No.3

Carnosine(Carn) is a dipeptide of β-Alanine and Histidine and occurs in high concentrations in skeletal muscle. Carn is highly effective in buffering H<SUP>+</SUP> over the physiological pH range, and probably the only such active compound where the concentration can be changed by diet. This study was performed to investigate the effect of 4 weeks β-alanine supplementation (6.4g/d) on isokinetic and anaerobic exercise performance capacity. Ten young elite swmmermale volunteers (25-30yrs) supplemented with 6.4g of β-alanine per day (4 times/d) during 4 weeks. Subjects undertook Wingate tests and isokinetic tests at 60°/s, 180°/s and 240°/s before and after supplementation. The Peak power(829±170 vs 946±127) and Fatigue Index(15.92±4.1 vs 19.44±3.1) were increased (p<.05) and Peak torque in flexor at 60°/s was increased(153±29 vs 186±39) with the supplementation (p<.01). These results indicated that the increased carnosine concentration by the β-alanine supplementation (6.4g/d) during 4 weeks in this study is likely contribute to both isokinetic and anaerobic exercise capacity.

Tau23 동물에서 손상된 HSP90-mediated autophagic/lysosomal pathway의 운동의 개선 효과

김용안(Kim Yong-An),손희정(Son Hee-Jeong),박준영(Park Joon-Young),김범수(Kim Bum-Soo),하재여(Ha Jae-Yeo),조임형(Cho lim-Hyeong),임예현(Leem Yea-Hyun) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.2

The objective of this study is to investigate whether chronic endurance exercise attenuates tau hyperphosphorylation and alters incomplete autophagic pathway. To achieve the objective of current study, 16 months of age of Tau23 mice were subjected to treadmill-running with 12m/min or 19m/min of speed for 12 weeks of period. the levels of neuropathophysiological phospho-sites on tau (pSer202, 204, 396, 404) were profoundly reduced in response to exercise. Autolysosomal activity-related LC3-Ⅱ/LC3-Ⅰ expression ratio and Cathepsin D expression were enhanced in Tg mice, but inversely declined in exercised Tg mice. Beeline-1 and p62, which were linked to autophagosome formation, expression levels were significantly reduced in Tg mice. HSP90 and CHIP, which play key role in escorting toward autophagy, expression levels were increased or decreased, respectively in Tg mice, and were reversed in exercised Tg mice. Based on our findings, chronic exercise suggests to ameliorate the incomplete and immature autophagic activity by Tau overexpression and hyperphosphorylation, resulting in reduction of Tau hyperphosphorylation.