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- 저자 : 최태승(Tae Seung Choe) (검색결과 4 건)
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지속적 외래 복막 투석이 당뇨성 신부전 환자의 β2-Microglobulin 에 미치는 영향
최태승(Tae Seung Choe),김선숙(Sun Sook Kim),권영주(Young Joo Kwon),조원용(Won Yong Cho),김형규(Hyoung Kyu Kim),원동준(Dong Joon Woo) 대한내과학회 1991 대한내과학회지 Vol.41 No.3
N/A To evaluate the effect of CAPD on the removal of beta-2-microglobulin (B2MG) in the patients with diabetic renal failure, serum levels and clearances of creatinine, urea, and B2MG, ultrafiltration rates, mass transfer raters of B2MG, and equilibration curves were determined in 5 diabetics and 5 nondiabetics with chronic renal failure undergoing CAPD. The study was carried out using peritoneal dialysis solutions with 1.5% dextrose for 240minutes of dwell time. The valuse of plasma were the means of 2samples taken at the start and after 240minutes. The values of peritoneal dialysis solution were determined on 3mlsamples taken at the 30minutes, 60minutes, 120minutes, and 240minutes after dialysate infusion. The authors results are as follows; 1) The serum R2MG levels were 39.4mg/1 in nondiabetic and 18.2mg/1 in diabetic renal failure groups which were significantly higher values than normal values and significantly lower values than that of hemodialyzed patients. 2) The peritoneal clearances of B2MG were 0.64 ml/ min in nondiabetic and 0.90ml/min in diabetic renal failure groups which represented 7.7% and 11.0% of dialysate flow rate in each groups. In diabetic renal failure group, patient 'age and mass transfer rate of B2MG were positively correlated with the peritoneal clearance of BRMG (r=0.25 and 0.76). 3) The equilibration curves of creatinine and urea were well fitted to their standard equilibration curves in both groups. In diabetic renal failure group, the dialysate to plasma ratios of creatinine and urea showed the linear correlation with the in-dwelling time during the 240minutes of dwell time (r=0.9964 and 0.9742) 4) The equilibration curves of B2MG showed that the D/P ratios of the diabetic group were constantly higher than those of nondiabetic group. The equilibration slopes between 120minutes and 240minutes after indwelling were significantly lower than those between the start and 120minutes after dwelling in each nondiabetic and diabetic groups. In conclusin, the standard CAPD may allow a constant B2MG removal diabetic renal failure patients by the means of diffusion and increased peritoneal vascular permeability of B2MG.
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실험적 급성 허혈성 (虛血性) 신부전 (腎不全)에서 Ca++ - ATPase 의 발현양상과 칼슘길항제의 효과
신종인(Jong In Shin),변현주(Hyoun Ju Byoun),이규백(Kyu Baik Lee),최태승(Tae Seung Choe),조원용(Won Yong Cho),김형규(Hyoung Kyu Kim) 대한내과학회 1991 대한내과학회지 Vol.41 No.1
N/A Calcium has been implicated as a primary pathogenetic mediator of cellular injury under conditions of oxygen and substrate deprivation in the kidney such as ischemic acute renal failure (ARF). However, the role of Ca++-ATPase in ischemic ARF, one of the important intracellular calcium regulation machineries participating in calcium ion translocation is unclear. The authors evaluated the changes of Ca+-ATPase before and after renal ischemia. The experimental animals, cats, were divided into 3 groups. Group I (n=6) was ischemic ARF model by renal artery clamp for 60 minutes, Group II (n=5) was ischemic ARF with a verapamil pretreatment (5 ㎍/kg/ min), systemically, and Group III (n = 7) was the same as Group II but with nonsteroidal antiinflammatory drug pretreatment. The results were as followings: 1) In Group I, creatinine clearance was 10.79±7.19 ml/min/kg before clamp and decreased to 2.09±1.70 ml/min/kg, and Group II, 3.41±1.56 to 0.12±0.05 ml/min/kg, and in Group III, 6.8±5.6 to 0.8±0.7ml/min/kg, respectively. 2) Creatinine clearance decreased significantly in Group II, 96±2% compared with Group I, 61±30%. A reduction of creatinine clearance in Group III was 84±11%, not different significantly from the other groups. 3) A Ca++-ATPase of renal tubular cell in the preischemic period was almost negative. The luminal and posterobasal surface of the proxima1 tubule showed slightly increased Ca++-ATPase activities in the postischemic period but the difference of location and activity of Ca++-ATPase among each group was not significant. These results suggested that Ca++-ATPase was activated after ischemia to compensate for ischemic insults resulting in increased intracellular calcium. There were no benefits to protecing renal function from ischemia and therefore no effects on the location and activity of Ca++-ATPase by systemic pretreatment of verapamil for ischemic ARF.
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만성 신부전 환자에서 Catecholamine 의 제거율
이은주(Eun Joo Lee),위경소(Kyoung So Wee),최태승(Tae Seung Choe),차대룡(Dae Ryong Cha),조원용(Won Yong Cho),김형규(Hyoung Kyu Kim),김형건(Hyoung Gun Kim),최원충(Won Chung Choi) 대한내과학회 1989 대한내과학회지 Vol.37 No.5
N/A The adrenergic system interacts with a vaiety of tissues and organs, including the kidney. However, there is little known about the renal clearance of catecholamine (CAs) in man. To obtain this information, 4 normal subjects and 6 patients with chronic renal failure (CRF) were studied. Plasma and urinary CAs concentrations were measured by high performance liquid chromatography with an electrochemical detector. Plasma CAs concentrations (pg/ml) were norepinephrine (NE) 44.62±83.29 (pg/ml) end DOPAC 585.58±462.47 in normal subjets, and NE 632.20±290.40 and DOPAC 990.55±69.05 in CRF. Plasma CAs concentrations of the CRF group were higher than those of normal subjects, but did not differ significantly among the groups (p<0.05). Urinary CAs excretion amounts were NE 59.3±34.9 (pg/ml), E 11.9±10.2. DOPAC 27.l±61.4, and dopamine 13.4±11.2 in normal subjects, and NE 100.0±90.1, E 135.5±147.4, DOPAC 401.7±500.7, and dopamine 163.9±115, 7 in CRF. Urinary CAs and CAs clearance levels were lower in the CRF group than in normal subjects, but did not differ significantly between the groups. It is concluded that a chronic reduction in excretory kidney function may have no relevant impact on circulatory levels of CA per se, although their urinary excretion falls distinctly at the stage of advanced renal failure. These aspects deserve consideration when pathogenetic or diagnostic studies of catecholamines are performed in normotensive or hypertensive patients with impaired kidney function.
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한국형 출혈열 환자에서 혈장 Catecholamine의 변화
정동국,최태승,김용섭,류승관,조원용,김형규,원동준 대한내과학회 1990 대한내과학회지 Vol.38 No.1
To evaluate the relationship between plasma catecholamines and the pathogenesis of acute renal failure(AFR), the plasma NE, E, Dopamine, DOPA and DOPAC were measured in 13 cases of Korean hemorrhagic fever(KHF) with renal failure and 12 normal persons as a control group by HPLC with ECD. To correlate these values with other renal functions, the blood pressure(systolic and diastolic), pulse rate, serum creatinine and creatinine clearance were measured. The results were failure as follows: 1) In 13 cases of KHF with renal failure, the plasma NE was increased in the oliguric and diuretic phases compared with the control group(p<0.05). The plasma E was also increased in the diuretic phase(p<0.05). 2) In the follow-up 7 cases, plasma E and NE were decreased in the diuretic phase(p<0.05). 3) The plasma E had a positive correlation with plasma Cr in the oliguric phase and a negative correlation with plasma Cr in the diuretic phase. The plasma NE had a positive correlation with plasma Cr in the diuretic phase. From these results, the increased synthesis of catecholamines is considered to be one of the pathogenic factors in KHF with acute renal failure. And the renal response to changes of catecholamines may be different with each phase in Korean hemorrhagic fever.
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