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다약물 내성기전으로서 ABC transporter와 화학감작제의 개발
최철혁,권대승,최석민 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2
Anticancer resistance is one of the major problems in the clinical cancer chemotherapy. Of resistance mechanisms are ATP (ATP-binding cassette) transporters including P-glycoprotein. In this paper, ABC transporters with respect to the physiological functions and multidrug resistance mechanisms as well as the development of chemosensitizers for their reversal have been reviewed.