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천은재,박준은,황인찬,정현주 대한소아혈액종양학회 2017 Clinical Pediatric Hematology-Oncology Vol.24 No.2
Background: Severe neutropenia is defined as an absolute neutrophil count (ANC) less than 0.5×109/L, which is known to increase the risk of serious bacterial infections. The aim of this study was to investigate characteristics, etiology and differences between transient and chronic severe neutropenia in children. Methods: 204 children, who were diagnosed with severe neutropenia at the Ajou University Hospital during a 5-year period, were included in the study. Clinical and laboratory features were analyzed. The patients were classified as having transient severe neutropenia (TSN) if recovery occurred within 6 months of diagnosis, and chronic severe neutropenia (CSN) if the neutropenia persisted for 6 months or more. Results: 184 (90.2%) patients with TSN and 20 (9.8%) patients with CSN were identified. Most of the TSN occurred in patients less than 2 year of age (75.5%) and rarely occurred in patients 5 years or older (5.4%). The most common cause of TSN was infection-related neutropenia (82.6%), and most of the associated infections were respiratory infections (44.6%). Compared to TSN, CSN patients were younger at diagnosis (1.00 vs. 0.71, P<0.001), had a lower ANC at diagnosis (364.8 vs. 214.9, P<0.001), lower ANC at nadir (356.0 vs. 50.0, P<0.001), and higher platelet count (188×109 vs. 308×109, P<0.001), monocyte count (491.5×106 vs. 832.9×106, P=0.010) and CRP (0.22 vs. 0.85, P=0.036). Conclusion: Most of the severe neutropenia occurred in children younger than 2 years of age, and virus infection was the most common cause of TSN.
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학교 밖 청소년의 진로체험 교육을 위한 지역사회 소자본 창업자와 청소년 단체의 자율적 협력 사례
최예솔,천은재 한국문화융합학회 2023 문화와 융합 Vol.45 No.5
This study was conducted to propose a development plan for balanced career education by overcoming the limitations that career education in Korea is concentrated on general youth, centered on the Ministry of Education and schools, and expanding the interest of career education to out-of-school youth and community cooperation. To this end, we looked at the cases of career experience education for out-of-school teenagers conducted by community small capital founders and youth organizations autonomously. As a result, it was found that the background of small-capital founders in the community participated in the program, the role played in the process of implementing the program, the benefits experienced, and the disappointment. In addition, it was confirmed that the case was an ideal type of career experience education. Furthermore, a plan was proposed for the development and revitalization of career experience education programs for out-of-school youth.
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다운증후군에서 일과성골수증식질환과 백혈병의 임상적 특성의 차이에 대한 단일기관 연구
황인찬,양새미,천은재,황금빛,정현주,이장훈,박문성,박준은 대한소아혈액종양학회 2017 Clinical Pediatric Hematology-Oncology Vol.24 No.1
Background: Children with Down syndrome (DS) have a 10- to 20-fold increased risk of developing leukemia. However, in some patients, leukemia does not become apparent despite significant number of blast cells in the peripheral blood. This condition is called Transient myeloproliferative disorder (TMD), and is a disease entity unique to DS newborns and defined as the morphologic detection of blasts in DS less than three months of age. The present study investigated whether there was a difference between leukemia and TMD, and determined prognostic and risk factors. Methods: We collected blood samples from 317 patients of 433 DS confirmed patients. We found 18 patients who had blast cells in their peripheral blood. Results: Twelve patients were positive for blasts during the neonate period, and only one patient progressed to leukemia. The other 11 patients were later diagnosed with TMD. Six more patients were later diagnosed with leukemia, therefore, 7 patients were diagnosed with leukemia in total. All patients diagnosed with leukemia had anemia at the time of diagnosis, which was not found in TMD patients. All leukemia patients developed their disease after three months of life. Acute Myeloid Leukemia (AML) patients had additional chromosome mutation to trisomy 21 when they were diagnosed. Conclusion: In patients with Down Syndrome, anemia at diagnosis and age of onset could be helpful in distinguishing TMD from acute leukemia. Cancerous mutations in the chromosomes of peripheral and marrow blast cells of Down syndrome patients may foreshadow acute leukemia.
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