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신규 Capsaicin 유도체 DA-5018을 함유한 외용진통제의 제제설계 I : 평가법 확립 및 외용크림제의 설계
차봉진,이응두,김원배,이민화,Cha, Bong-Jin,Lee, Eung-Doo,Kim, Won-Bae,Lee, Min-Hwa 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
To formulate the topical analgesic preparation of a new capsaicin derivative, DA-5018, a skin penetration evaluation system was established and the effect of composition of formulation on skin penetration using this system was evaluated, The effect of massage on hairless mouse skin penetration and inter-day variation of this effect were investigated using test formulations(cream). In massage group, compared with non-massage group, absolute penetration amount of DA-5018 increased and this experimental system was found to be reproducible, The effects of pH of water phase, ratio of oil/water and the concentration of active ingredient in cream on skin penetration were investigated. The permeation of DA-5018 from the cream increased with increasing pH of water phase to 9. But at pH 10, the permeation of DA-5018 decreased, because of the physical instability of the cream. The permeation of DA-5018 from the cream increased with increasing the ratio of oil/water of the cream. The increase of the content of DA-5018 to 0.3% increased the permeation of DA-5018, but at high concentration(1.0%), the permeation of DA5018 decreased, due to the instability of the cream.
신규 Capsaicin 유도체 DA - 5018 을 함유한 외용진통제의 제제설계 Ⅰ: 평가법 확립 및 외용크림제의 설계
차봉진,이응두,김원배,이민화 ( Bong Jin Cha,Eung Doo Lee,Won Bae Kim,Min Hwa Lee ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A To formulate the topical analgesic preparation of a new capsaicin derivative. DA-5018, a skin penetration evaluation system was established and the effect of composition of formulation on skin penetration using this system was evaluated. The effect of massage on hairless mouse skin penetration and inter-day variation of this effect were investigated using test formulations (cream). In massage group, compared with non-massage group, absolute penetration amount of DA-5018 increased and this experimental system was found to be reproducible. The effects of pH of water phase, ratio of oil/water and the concentration of active ingredient in cream on skin penetration were investigated. The permeation of DA-5018 from the cream increased with increasing pH of water phase to 9. But at pH 10, the permeation of DA-5018 decreased, because of the physical instability of the cream. The permeation of DA-5018 from the cream increased with increasing the ratio of oil/water of the cream. The increase of the content of DA-5018 to 0.3% increased the permeation of DA-5018. but at high concentration(1.0%), the permeation of DA-5018 decreased, due to the instability of the cream.
HPLC 법에 의한 혈중 Clofibric Acid 의 정량법 개선 및 응용
차봉진(Bong - Jin Cha),민신홍(Shin - Hong Min),전흥원(H . Won Jun) 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.4
An improved procedure for the quantitation of clofibric acid in human serum by high performance liquid chromatography with fluorescence detection was developed. The assay is simple, accurate, reproducible and was validated at the concentrations of 0.3-100 ㎍/㎖ in human serum. Regression analysis for the standard plots obtained from intra-day and inter-days studies indicated excellent linearity(r>0.999) and reproducibility(CV, 3.4-5.0%). The pharmacokinetic profile in human could be obtained over seven times the elimination half-life after a single oral dose of 500㎎ of clofibrate.
유아교사의 교사효능감이 4세 누리과정 실행수준에 미치는 영향
차봉진 ( Bong Jin Cha ),홍순옥 ( Soon Ohk Hong ),김근혜 ( Geun Hye Kim ) 한국어린이문학교육학회 2015 어린이문학교육연구 Vol.16 No.1
본 연구는 유아교사의 교사효능감이 4세 누리과정 실행수준에 어떠한 영향을 미치는지 알아보고, 4세 누리과정의 실행수준을 높일 수 있는 방안과 유아교육의 질에 영향을 줄 수 있는 유아교사에 대한 효능감 및 사회전반의 관심을 제고시키는데 목적이 있다. 본 연구는 B시의 유치원과 어린이집에서 4세 누리과정을 실행하고 있는 유아교사 311명을 대상으로 설문조사를 실시하였으며, 수집된 자료는 SPSS 21.0프로그램을 이용하여 평균과 표준편차, 일원변량분석, Scheffe사후분석, Pearson``s 상관분석과 다중회귀분석을 실시하였다. 이에 따른 연구결과는 첫째, 유아교사의 연령과 경력, 학력이 높을수록 교사효능감이 높은 것으로 나타났다. 둘째, 유아교사의 연령과 경력이 높을수록 4세 누리과정의 실행수준이 높은 것으로 나타났다. 셋째, 4세 누리과정을 실행하는 유아교사의 교사효능감과 누리과정 실행수준은 정적 상관관계가 있는 것으로 나타났다. 넷째, 4세 누리과정을 실행하는 유아교사의 교사효능감과 누리과정 실행수준에 미치는 상대적인 영향을 알아본 결과, 개인적 효능감이 가장 큰 설명력을 보였다. The purpose of this study was to supplement the Nuri curriculum by investigating the practicing level of the Nuri curriculum for 4-year olds according to the demographic background of early childhood teachers. The research objects are 311 preschool teachers who manage and teach the age four Nuri curriculum at preschools and day care centers in city “B”. The research tools are survey from Son Suyeon’s (2012) research is supplemented and revised to study the practice level of the preschool teachers and surveys from Kim Jungjoo (2003) and Kim Eunmi’s (2013) research are supplemented and revised to study the teacher efficacy. For the research analysis methods, percentage average and standard deviation calculation and one-way ANOVA are performed, Scheffe Test is performed for post test, and Pearson’s Correlation Analysis and Multiple Regression Analysis are performed. The results of this study were as follows. First, the overall average of the Nuri curriculum practice level for the preschool teachers who teach age four children is 3.84, which is higher than the average of 3.00, out of 5.00. Also, in relation to teachers’ general characteristics, it is shown that as age and number of years in experience are higher the level of practice for the Nuri curriculum is also higher. Second, the teacher efficacy for the preschool teachers who teach age four children is 3.79, which is higher than the average of 3.00, out of 5.00. The general teacher efficacy is found higher than the personal teacher efficacy. Also, there are significant differences in the teacher efficacy according to the general characteristics in the following order: age, experience, and education level of the teachers. Third, there is a positive relationship between the Nuri curriculum practice level and the teacher efficacy for teachers of age four children. By studying the relationship between the subfactors of the Nuri curriculum practice level and the efficacy of the preschool teachers who teach age four children in detail, education method showed the highest mutuality in the teacher efficacy and the education assessment was the next highest. Through these results, one can acknowledge that overall a significant relationship exists between the Nuri curriculum practice level and the teacher efficacy of the preschool teachers who teach age four children. Fourth, the teacher efficacy of the preschool teachers who teach age four children has a positive effect on the Nuri curriculum practice level. The variables that have significant effects are the general teacher efficacy and the personal teacher efficacy. Higher the teacher efficacy, higher the Nuri curriculum practice level of the preschool teachers who teach age four children.
Liquid Suspension 법에 의해 제조한 Stearyl Alcohol 구형 Matrix 에 관한 연구
차봉진 ( Bong Jin Cha ),이민화 ( Min Hwa Lee ) 한국약제학회 1984 Journal of Pharmaceutical Investigation Vol.14 No.1
Spherical matrixes were prepared from liquid suspension. The drug (sulfamethoxazole) particles dispers ed in distilled water were agglomerated with a melt of matrix material (stearyl alcohol), so dense and free-flowing agglomerates were obtained. The factors affecting the average size, drug content and the release behavior of the resultant products were investigated. The geometric mean diameters and drug contents were affected primarily by the species of matrix, the amountof matrix, and drug particle-size used. In-vitro dissolution studies indicated that the drug was released as a first-order kinetic model. Ths release behaviors varied with the species of matrix, the amount of matrix, size fraction, and drug particle-size used. Steary alcohol proved to play the weak role of matrix in basic medium.
솔레노이드 장치를 이용한 양식용 부자 LED 전원공급 시스템 개발
차봉진 ( Bong-jin Cha ),배봉성 ( Bong-sung Bae ),김현영 ( Hyun-young Kim ),조삼광 ( Sam-kwang Cho ),이건호 ( Gun-ho Lee ) 한국어업기술학회 2016 수산해양기술연구 Vol.52 No.1
This study investigates the development of an automatic lightening buoy that can indicate an aquaculture cage at night or in rough weather. The energy for the light is generated by the linear motion of a magnet along with a coil inside the buoy as the waves cause the buoy to oscillate up and down. The principle of the magnet motion is different between the magnet and body of the buoy because the movement of the latter is dependent on the surface wave, while the former is affected by the damper. To obtain a quantitative performance of the buoy, the voltage as well as up and down motion produced by several waves were measured in the wave tank. A shorter wave period, i.e., faster motion, of the magnet produced a brighter light. It is expected that this study can aid in deciding the optimum design of a buoy capable of producing a bright light at any aquaculture site affected by sea or fresh water waves.