진행성 비소세포성 폐암환자에 대한 항암플러스의 치료효능 : 연속증례보고

정홍매,윤정원,이연월,조종관,오달석,유화승,Zheng, Hong-Mei,Yoon, Jeung-Won,Lee, Yeon-Weol,Cho, Chong-Kwan,Oh, Dal-Seok,Yoo, Hwa-Seung 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.1

Objectives : A case series was conducted to investigate the therapeutic effects of Hang-Am Plus (HAP) on the tumor response and HRQoL (Health Related Quality of Life) in advanced non-small cell lung cancer (NSCLC) patients. Methods : Three patients were given 1,000-2,000 mg of HAP, three times a day (daily total dosage of 3,000-6,000 mg/day) for 12 weeks. Results : After the 3 month administration with HAP, three patients showed stable disease (SD) condition according to the chest computed tomography (CT), and two of the patients reported a decrease in pain levels. Conclusions : The observed NSCLC cases suggest treatment with HAP may be related to the observed tumor growth inhibition and pain reduction.

자음강화탕 투여 후 상열감의 호전을 보인 타목시펜 복용 중인 유방암 환자 1례

정홍매,이연월,유화승,조종관,Zheng, Hong-Mei,Lee, Yeon-Weol,Yoo, Hwa-Seung,Cho, Chong-Kwan 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.2

Objective : To observe the effectiveness of Jayeumganghwa-tang on hot flush of a breast cancer patient who takes tamoxifen. Methods : For six weeks a dosage witch contained 13.92g of Jayeumganghwa-tang was administered 3 times (30 mins after meal) per day, for improvement of hot flush. No other therapies like hormone therapy or substituted therapy were done. Results : As a result of 6 weeks of Jayeumganghwa-tang therapy, the patient who suffered hot flush on taking tamoxifen showed improvement on several indices, including frequency, intensity and point of hot flush, Beck Depression Inventory-K (BDI-K) which shows uneasiness and sadness, and also Functional Assessment Cancer Therapy - Breast (FACT-B) which is an index of life quality of breast cancer patients. But no changes on female hormones like follicle-stimulating hormone (FSH) or luteinizing hormone (LH) were observed. Conclusion : This case demonstrates 6 weeks of Jayeumganghwa-tang taking had no effect on female hormones but can reduce the hot flush by tamoxifen. This shows minimum evidence of safety and efficacy of Jayeumganghwa-tang on hot flush of breast cancer patient. However this is a single case study so further case-series research should be compiled.

수레바퀴 암 치료법에 대한 근거중심적 연구

정홍매,윤정원,유화승,조종관,Zheng, Hongmei,Yoon, Jeungwon,Yoo, Hwa-Seung,Cho, Chong-Kwan 대한암한의학회 2012 大韓癌韓醫學會誌 Vol.17 No.2

Background : Integrative cancer treatment is a holistic approach embracing body, mind, and spirit incorporating conventional treatments of surgery, chemotherapy, radiation and personalized complementary treatments. Wheel Balance Therapy (WBT) of East-West Cancer Center(EWCC), Dunsan Oriental Hospital of Daejeon University was developed to balance out all factors involved in cancer care based on the traditional theories of oriental medicine. Objective : This work aims to analytically review literatures on WBT and its related components. Methods : Literatures published from January 1st, 1990 to April 30th, 2011 were reviewed focusing on 4 main components of WBT; herbal medicine, immune activation, anti-cancer diet, and breathing/meditation. Data were retrieved from medical search engines and electronic data bases including Pubmed, Research Information sharing Service (RISS), Korean-studies Information Service System (KISS), China National Knowledge Infrastructure (CNKI), and Korea's National Digital Library (KNDL). Results : In this review, EWCC's most commonly prescribed formulas are explored. The composition of the formulas, their use in clinical settings as well as the background studies and other therapeutic efficacies are explained. Information on incorporating anti-cancer dietary support and breathing and meditation techniques, other therapies practiced as part of the center's integrative cancer care are also covered. Conclusion : WBT based on holistic theories of oriental medicine embracing body, mind, and spirit is expected to further contribute in promotion of cancer patients' quality of life and prolonged survival time.

비진행성 암환자의 암성 피로에 대한 바나듐수의 효능 : 무작위배정 이중맹검 대조군 시험

정홍매(Hong-Mei Zheng),김동희(Dong-Hee Kim),이석훈(Suk-Hoon Lee),박유경(Yoo Kyoung Park),유화승(Hwa-Seung Yoo) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.12

본 연구는 1일 1.5 L씩 4주간의 바나듐수 음용이 비진행성 암환자의 피로감 개선에 긍정적인 효과를 미치는 지 확인하기 위하여 수행되었다. 본 연구 결과 4주간의 바나듐수 음용은 비진행성 암환자의 피로감 개선을 위해 통계적으로 경계선상의 유의성을 보였으므로 향후에는 탐색형 연구로부터 확증형 연구를 통하여 피험자 수가 증가할 경우 통계학적으로 유의성을 보일 것이라고 예상되므로 근거 확보를 위한 진일보한 연구가 이루어져야 할 것이다. 즉 1일 1.5 L씩 4주간의 바나듐수 음용은 비진행성 암환자의 피로감 개선에 대해 유의수준 10%에서 통계적으로 유의한 차이가 나타났다. 이는 바나듐수가 암 환자의 피로에 도움이 되고 또한 참여자 수가 늘어날 경우 통계학적으로 유의성을 보일 것이라는 최소한의 근거를 보여주는 것이다. 향후에는 피험자수의 증가를 비롯하여 성별, 암종별 피험자수를 매치하고 피로감 개선을 포함한 기타 추가 기능에 대한 연구 수행을 기대할 수 있겠다. This study was conducted to evaluate the efficacy and safety of vanadium water (VW) on cancer-related fatigue of non-advanced cancer patients. For the experimental group administration, participants consumed three 500 mL/bottle bottles of Jeju Island’s VW, which contained 15~20 ppb of vanadium, three times a day (morning, afternoon, evening) for 4 weeks (28 days) without any additional treatments for fatigue improvement. The control group participants consumed three 500 mL/bottle bottles of ordinary water (0 ppb of vanadium) three times a day for the same period of time without any additional treatments for fatigue improvement. After 4 weeks of VW consumption, total score of Revised Piper Fatigue Scale (RPFS) was reduced 30% compared to the basal score after Fisher’s Exact Test which resulted in a statistical borderline significance (p=0.0799) and result of t-test of comparison between two groups’ RPFS total score and fatigue cognitive/mood changes resulted in a statistical significance (p=0.0112). In detail, only 36.4% of control group (N=11) showed improvement while 77.8% of treatment group (N=9) showed fatigue improvement. No other lab measures, including thyroid hormone level indicated any significant differences between two groups. In conclusion, daily consumption of 1.5 L of vanadium water for 4 weeks showed improvement of non-advanced cancer patients’ fatigue.

비진행성 갑상선암 환자에 대한 제주워터의 항피로 효능에 대한 유효성과 안전성 평가 예비 임상연구 -무작위배정, 이중맹검, 삼군위약대조군 연구

정홍매 ( Hong Mei Zheng ),김동희 ( Dong Hee Kim ),이석훈 ( Suk Hoon Lee ),김경순 ( Kyung Soon Kim ),유화승 ( Hwa Seung Yoo ) 대전대학교 한의학연구소 2012 혜화의학회지 Vol.20 No.2

Objective : This study was conducted to evaluate of efficacy and safety of Vanadium Water (VW) on Cancer related Fatigue of Non-advanced Cancer Patients. Methods : Experimental Group Administration. Participants in treatment group consumed three 500 ml/bottle bottles of Jeju Island`s VW, which contains 40.2 ㎍/L of vanadium, three times a day (morning, afternoon, evening) for 4 weeks (28 days) without any additional treatments for fatigue improvement. The control group participants consumed three 500 ml/bottle bottles of ordinary water (0 ㎍/L of vanadium) three times a day for the same period of time without any additional treatments for fatigue improvement. Results : After 4 weeks of VW consumption, total score of Revised Piper Fatigue Scale (RPFS) was reduced 30% and basal score after Fisher`s Exact Test resulted statistical borderline significance (p=0.0799) and result of t-test of comparison between two groups` RPFS total score and fatigue cognitive/mood changes resulted statistical significance (p=0.0112). In detail, only 36.4% of control group (N=11) showed improvement while 77.8% of treatment group (N=9) showed fatigue improvement and thyroid hormone level changes. No other lab measures indicated any significant differences between two groups. Conclusion : Daily consumption of 1.5 L of Vanadium water for 4 weeks showed improvement of non-advanced cancer patients` fatigue.

뉴미디어시대 라지오뉴스 발전대책

정홍매(Jeong Hongmae) 길림성민족사무위원회 2012 중국조선어문 Vol.179 No.-