http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 정이숙(Jung Yee Sook) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
새로운 Dihydropyridine 유도체, KR-30006과 KR-1008의 심장순환계 약리작용
이병호(Byung Ho Lee),정이숙(Yee Sook Jung),권광일(Kwang Il Kwon),지옥표(Ok Pyo Zee) 대한약학회 1989 약학회지 Vol.33 No.3
KR-1008 and KR-30006 are 1,4-dihydropyridine derivatives, new vasodilatory calcium antagonists from KRICT. Calcium antagonistic properties of the compounds were studied in the isolated heart (Langendorff preparation), pulmonary artery (vasodilation), and in the papillary muscle (negative inotropic effect) of the guinea pig. Antihypertensive effect were also investigated after i.v. or oral administration in the SHR (spontaneously hypertensive rat). They produced a sigificant inhibition of Ca-induced contraction in the guinea pig pulmonary artery at the concentrations of above 10-8M. The negative inotropic effect of the electrically stimulated papillary muscle appeared from the concentration of 10-6M, which is about hundred times higer than the concentration of vasodilation effect. Left ventricular pressure also decreased from the concentration of 3 X 10-6M,in KR-1008 and KR-30006 in the Langendorff heart preparations. Coronary flow rate increased from 10-6M in KR-1008 and nicardipine and appeared no change in KR-30006. The antihypertensive effect of KR-1008 (EC 20 : 2.9mcg/kg) was potent more than nicardipine (EC 20 : 3.4mcg/kg) and than KR-30006 (EC 20 : 6.8mcg/kg) was, after i.v. bolus injection in the anesthetized SHR. The antihypertensive effect in the conscious SHR appeared 30 minutes after oral administration of 10mg/kg and persisted 4 hrs in KR-1008 and 12 hrs in KR-30006. Heart rate tended to increase for 0.5-1 hr after oral administration of the test compounds.
-
-
새로운 Dihydropyridine 유도체, KR-30006과 KR-1008의 심장순환계 약리작용
이병호,정이숙,권광일,지옥표 충남대학교 약학대학 의약품개발연구소 1989 藥學論文集 Vol.5 No.-
KR-1008 and KR-30006 are 1,4-dihydropyridine derivatives, new vasodilatory calcium antagonists from KRICT. Calcium antagonistic properties of the compounds were studied in the isolated heart (Langendorff preparation), pulmonary artery (vasodilation), and in the papillary muscle (negative inotropic effect) of the guinea pig. Antihypertensive effect were also investigated after i.v. or oral administration in the SHR (spontaneously hypertensive rat). They produced a sigificant inhibition of Ca-induced contraction in the guinea pig pulmonary artery at the concentrations of above 10^-8M. The negative inotropic effect of the electrically stimulated papillary muscle appeared from the concentration of 10^-6M, which is about hundred times higer than the concentration of vasodilation effect. Left ventricular pressure also decreased from the concentration of 3×10^-6M in KR-1008 and KR-3006 in the Langendorff heart preparations. Coronary flow rate increased from 10^-6M in KR-1008 and nicardipine and appeared no change in KR-30006. The antihypertensive effect of KR-1008 (EC 20:2.9 ㎍/㎏) was potent more than nicardipine (EC 20:3.4 ㎍/㎏) and than Kr-30006 (EC 20:6.8 ㎍/㎏) was, after i.v. bolus injection in the anesthetized SHR. The antihypertensive effect in the conscious SHR appeared 30 minutes after oral administration of 10 ㎎/㎏ and persisted 4 hrs in KR-1008 and 12 hrs in KR-30006. Heart rate tended to increase for 0.5-1 hr after oral administration of the test compounds.
ScienceON
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
