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수종 생약에 의한 Lens Aldose Reductase의 억제
정도래,박웅양,이승호,이경순,노재섭,Jeong, Do-Rae,Park, Woong-Yang,Lee, Seung-Ho,Lee, Kyong-Soon,Ro, Jai-Seup 한국생약학회 1993 생약학회지 Vol.24 No.1
To search for inhibitory activities for lens aldose reductase, twenty two medicinal plants were tested by the method of bovine lens aldose reductase inhibition test. In this test Rubia akane(68%), Artemisia selengensis(61%), Lespedeza cuneata (58%), Ligustrum lucidum(58%), Viola patrinii(58%) extracts were shown to have aldose reductase inhibitory activity. From the radix of Rubia akane, $2-methyl-1,\;3,\;6-trihydroxy-9,\;10-anthraquinone-3-O-(6'-O-acetyl)-{\alpha}-rhamnosyl-(1{\rightarrow}2)-{\beta}-D-glucoside$ was isolated and the $IC_{50}$ of this compound in the aldose reductase inhibition test was about $1.2{\times}10^{-6}M$.
한국산 복수초성분의 Na<sup>+</sup>, K<sup>+</sup>-ATPase활성에 대한 연구
노재섭(Jai Seup Ro),이경순(Kyong Soon Lee),박웅양(Woong Yang Park),오갑진(Kap Jin Oh),안병태(Beung Tae Ahn),어경춘(Kyong Chun Eo),정도래(Do Rae Jeong),Toshio Nambara(Toshio Nambara) 한국생약학회 1990 생약학회지 Vol.21 No.2
Four known cardiotonic steroids were isolated from roots of Adonis amurensis Regel et Radde and identified as digitoxigenin, cymarin, K-strophanthin and convallatoxin by chromatography on Amberlite XAD-2 zesin and silica gel, highperformance liquid chromatography and gel chromatography on Sephadex LH-20. In order to clarify the structure-activity relationship, thirteen related compounds of digi toxigenin were tested for the inhibitiory activities for Na^+, K^+-adenosine triphosphatase from guinea pig heart. The inhibitory activities of related compounds of digitoxigenin were dependent upon the dicarboxylic acid and amino acid components. The compound having both the arginine and suberic acid moiety showed the higher inhibitory activity. The sulfate and glucuronide of digitoxigenin exhibited much less potency than the parent genin.