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RISS 인기검색어
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- 저자 : 정강호(Gang Ho Jeong) (검색결과 3 건)
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제한병기 소세포성 폐암에서 복합화학요법과 방사선요법의 병용요법시 유발되는 백혈구감소증에 대한 Gracin ( rhG - CSF ) 의 임상효과
정강호(Gang Ho Jeong),송홍석(Hong Suck Song) 대한내과학회 1995 대한내과학회지 Vol.49 No.5
N/A Objectives: The aim of this study was to evaluate the efficacy of recombinant human gra- nulocyte colony stimulating factor(rhG-CSF; Gracin®) in ameliorating hematopoietic suppression in patients with limited stage small cell lung carcinoma undergoing induction therapy with cisplatin/etoposide and concurrent hyperfaractionated split-course thoracic radiotherapy. Methods: Twenty-one patients with limited stage small cell lung carcinoma received cisplatin 25mg/m(2)+ etoposide 120mg/m(2) on day 1,2, and 3. Courses repeated every 4weeks for a total of 4courses. Thoracic irradiation 60Gy in 25twice-daily fraction of 120cGy separated by at least 6hours, 5days/week, beginning on day 1 of course 1 of chemotherapy with an approximately 2week break after the first 28.8Gy such that radiotherapy was resumed approximately 4weeks after the 1st course of concurrent chemotherapy, rhG-CSF was started on day 4 of 1st or 2nd chemotherapy at a does of 75㎍/day subcutaneously for 14days. A concurrent chemoradiotherapy course without G-CSF was a control period and another course with G-CSF was a evaluation period. The efficacy and toxicity of G-CSF was evaluated according to the laboratory and hematologic changes betwen control and G-CSF treatment period. Results: 1) Total number of enrolled patients were 21with mean age of 59.5±5.0years. 2) The nadir count of leukocyte was significantly increased in G-CSF treatment period (control 1,665.7 877.0/μL vs G-CSF 2,459.5±1,120.5/μL, p=0.001). 3) The nadir count of neutrophil was also significantly increased in G-CSF treatment period(922.4±658.0/μL vs 1,495.2±829.2/μL, p=0.003). 4) The duration of leukopenia and neutropenia were significantly shortened in G-CSF treatment period compare to control period(p<0.001). 5) The recovery time of leukocyte from nadir to over 4,000/μL(11.1±6.7 vs 2.3±2.3 days, p<0.001), and of neutrophil from nadir to over 2,000/μL(9.1±7.2 vs 1.2±1.6 days, p<0,001) were significantly reduced in the G-CSF treatment period. 6) Side effects of G-CSF were skin rash in 2patients and mild fever, myalgia and bone pain in one patient, respectively which was spontaneously subsided without specific treatment. 7) The infection was observed in 3patients in control period, but no episode of infection was observerd in G-CSF treatment period, and the total numbers of days of treatment with intravenous antibiotics were significatly lower in G-CSF treatment period compare to control period, Conclusion: This results suggest rhG-CSF is effective and useful for the treatment of neutropenia induced by concurrent chemo-radiotherapy in patients with limited stage small cell lung carcinoma.
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진행성 악성종양환자에서 항암화학요법으로 인한 호중구소증에 대한 재조합 인 과립구 - 대식세포 콜로니 자극인자 ( rhGM - CSF ) 의 임상효과
송홍석(Hong Suck Song),정강호(Gang Ho Jeong),이춘식(Chun Sik Lee) 대한내과학회 1996 대한내과학회지 Vol.50 No.4
N/A Objectives: The aim of this study was to evaluate the efficacy and toxicity of remombinant human granulocyte-macrophage colony stimulating factor(rhGM-CSF, Leukogen®) in ameliorating hematopoietic suppression in patients with uarious malignancies undergoing myelotoxic combination chemotherapy. Methods: The efficacy of recombinant human GM-CSF was evaluated in 23 patients with various solid tumor and lymphoid malignancy in Keimyung University, Dongsan Medical Hospital during the period of March, 1994 to October, 1994. RhGM-CSF was started after 24 hours after 2nd chemotherapy at a dose of 250μg/m2/day subcutaneously for 10 days. The efficacy and toxicity of GM-CSF were evaluated according to the hematologic and laboratory changes between control and GM-CSF treatment period. Results: 1) Total number of enrolled patients were 23; 15 patients with lung cancer, 2 patients with breast cancer, 2 patients with stomach cancer and 1 patient with Ewing's sarcoma, soft tissue sarcoma, thymoma and Non-Hodgkin's lymphoma respectively. 2) The mean age was 51 and male was 16 patients. 3) The nadir count of leukocyte and neutrophil were significantly increased in GM-CSF treatment period, however that of platelet in GM-CSF treatment period were similar to control period. 4) The mean duration of WBC counts less than 4,000/μL, 2,000/μL and that of neutrophil counts less than 2,000/μL, 1,000/μL and 500/μL were significantly shortened in GM-CSF treatment period. 5) The recovery time of leukocyte from nadir to over 2,000/μL, and of neutrophils from nadir to over 2,000/μL, 1,000/μL were significantly reduced in GM-CSF treatment period. 6) The days of hospitalization due to infection was significantly reduced in GM-CSF treatment period. Days with termperature exceeding 38.5℃ and days of treatment with parenteral antibiotics were decreased in the CM-CSF treatment period, but not significant to control period. 7) Adverse reactions with rhGM-CSF were observed in 11 patients(48%) which were not life threatening, and rapidly reversible. They included myalgia in 7 patients, fever in 6 patients, abdominal pain in 3 patients, dyspnea in 3 patients, vomiting in 2 patients, and bone pain, fatigue and diarrhea in 1 patient respectively. Conclusion: RhGM-CSF significantly elevated the nadir counts of leukocytes and neutrpphils, shortened the duration and the recovery time from neutropenia. We concluded that it was useful and effective for the treatment of neutropenia induced by myelotoxic chemotherapy in patients with various advanced malignancy.
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Fluconazole 투여로 양호한 경과를 보인 경부 및 종격동림프절 효모균증 1예
허정숙,정화영,정강호,송홍석,이춘식,도영록 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.3
저자들은 선행질환이 없는 건강하던 환자에서 경부 및 종격동림프절종대의 소견을 보여 악성림프종으로 의심했던 환자에서 조직검사를 통해 효모균증을 증명하고 triazole 계 항진균제인 fluconazole을 사용하여 양호한 경과를 보인 1예를 경험하였기에 문헌고찰과 함께 보고 하는 바이다. Cryptococcosis is a subacute or chronic mycotic infection caused by Cryptococcus neoformans. Authors experienced a case of cryptococceosis, resembling malignant lymphoma that restricted in cervical and mediastinal lymph node. A 44-year-old female patient was admitted with complaints of weight loss, fever, chill and palpable multiple neck mass. Chest PA and CT scan showed multiple discrete nodular masses in both cervical, hilar, supraclavicular and mediastinum. In section of cervical and mediastinal lymph node biopsy, Fontana-Masson and mucicarmine positive-cryptcoccus was found. And there was no evidence of malignant lymphoma. The patient was treated with oral fluconazole 400mg/day for 3 months and showed good response.
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