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RISS 인기검색어
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- 저자 : 전세아 ( Se Ah Jeon ) (검색결과 2 건)
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소아 키위 알레르기의 임상 특성과 특이 immunoglobulin E 항체의 유용성
이정민 ( Jeong Min Lee ),전세아 ( Se Ah Jeon ),이수영 ( Soo Young Lee ) 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.1
Purpose: Kiwi fruit allergy in children has scarcely been reported. This study focused on the clinical characteristics of kiwi fruit allergy and value of kiwi specific Immunoglobulin E (IgE) antibodies in Korean children. Methods: The study was based on a data analysis of 18 patients, who were diagnosed with clinical kiwi fruit allergy at Ajou University Hospital from June 2005 to June 2012. Clinical details were collected by medical history and telephone survey. Sera from all children were analyzed for kiwi specific IgE (ImmunoCAP) and patients with negative result were further evaluated by an enzyme linked immunosorbentassay test (ELISA) using our own made kiwi fruit extracts. Results: The subjects were 10 male and 8 female with a median aged 25 months. Twelve out of 18 (66.7%) were diagnosed with angioedema or urticaria, 4 (22.2%) were diagnosed with oral allergy syndrome, 1 was presented with dyspnea, and 1 was diagnosed with anaphylaxis. Oral route of exposure (88.9%) was most common and majority of patients (88.9%) experienced clinical symptoms at the first exposure to kiwi fruit. Six out of 12 patients with urticaria showed negative result in specific IgE by ImmunoCAP, but specific IgE were detected in 2 of 6 by ELISA with our own made kiwi extract. Conclusion: Systemic reactions to kiwi fruit were common in Korean children, and the symptoms were frequently developed at the first time of exposure. Additional diagnostic methods would be needed for evaluation of IgE sensitization in kiwi allergic patients with negative result by ImmunoCAP. (Allergy Asthma Respir Dis 1(1):73-78, 2013)
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소아 키위 과일 알레르기 환자에서 성분 항원 진단의 효용성
이정민 ( Jeongmin Lee ),김혜보 ( Hyebo Kim ),정경욱 ( Kyunguk Jeong ),전세아 ( Se-ah Jeon ),이수영 ( Sooyoung Lee ) 대한천식알레르기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.2
Purpose: In food allergy, significant component antigens can be assessed by using the microarray. The purpose of this study was to evaluate the diagnostic value of component resolved diagnosis (CRD) in young children with kiwifruit allergy. Methods: Through a retrospective review of medical records, we evaluated the clinical characteristics of 12 children who underwent measurement of serum immunoglobulin E concentrations to kiwifruit (kiwi-sigE) and were diagnosed as kiwifruit allergy. We ap plied ImmunoCAP ISAC-CRD 112 using the residual sera of patients at the initial visit. Results: The median age of kiwifruit allergic children was 33.5 months (range, 13 to 84 months), and the proportion of systemic re actions, including 2 anaphylaxis cases, was 66.7%. Four had localized reactions on the lips. A total of 11 (91.7%) were sensitized to Act d 1; among them, 8 were mono-sensitized to Act d 1 and 3 were sensitized to ≥2 kiwifruit components. There was no significant difference in CRD results between those with systemic reactions and those with local reactions. Conclusion: Act d 1 is the major allergenic component in Korean young children with clinical kiwifruit allergy. The additional diag nostic value of the CRD in diagnosing and predicting the severity of kiwifruit allergy is expected to be low in young children. (Allergy Asthma Respir Dis 2022;10:105-109)
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