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가속도계를 이용한 진전현상의 분석을 통한 파킨슨병과 본태성 진전의 판별
이홍지,이웅우,전효선,김상경,김한별,전범석,박광석,Lee, Hongji,Lee, Woongwoo,Jeon, Hyoseon,Kim, Sangkyong,Kim, Hanbyul,Jeon, Beom S.,Park, Kwangsuk 대한의용생체공학회 2015 의공학회지 Vol.36 No.4
Discrimination of Parkinson's disease (PD) from Essential tremor (ET) is often misdiagnosed in clinical practice. Since tremor is time-varying signal, and dominant and harmonic frequencies are shown in tremor only with moderate or severe symptom, there are some limitations to use frequency related features. Moreover, patients with PD or ET can suffer from both resting tremor and postural tremor. In this study, 28 patients with PD and 17 patients with ET were enrolled. Tremor was measured with accelerations on the more affected hand during resting and postural conditions. The ratio of root mean square (RMS) of resting tremor to RMS of postural tremor, the mean coefficients of autocorrelation function (ACF), and the mean of differences of two adjacent coefficients of ACF at resting and postural were calculated and compared between PD and ET. The performance showed 98% accuracy with support vector machine and leave-one-out cross validation. In addition, the method accurately differentiated the patients with tremor-dominant PD from patients with ET, with 100% accuracy. Therefore, the developed algorithm can assist clinicians in diagnosing and categorizing patients with tremor, especially, patients with mild symptom or the early stage of a disease, for proper treatment.
아이들링 진동응답 예측을 위한 엔진마운트의 실험적 설계변경
정의봉(Weui-Bong Jeong),조영희(Young-Hee Cho),김원영(Won-Young Kim),전범석(Beom-Seok Jeon) 한국자동차공학회 1997 한국자동차공학회 춘 추계 학술대회 논문집 Vol.1997 No.6_2
Experimental transfer function synethesis method is developed and applied to the engine-mount systems of construction vehicles. The frequency response functions of combined structure(engine+frame) are estimated from the experimental data of component structure. Transmitted forces through engine-mounts are estimated from idling responses by least square method. Idling responses of vehicle can be also predicted when the characteristics of engine-mounts are modified. The predicted results are compared with experimental data, and the results show the usefulness of the method.<br/>
이명철(Myung Chul Lee),이경한(Kyung Han Lee),윤병우(Byung Woo Yoon),이원용(Won Yong Lee),이기형(Ki Hyeong Lee),이상복(Sang Bok Lee),전범석(Beom S . Jeon) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.1
N/A Progressive supranuclear palsy (PSP) is a parkinson-plus syndrome characterized clinically by supranuclear ophthalmoplegia, pseudobulbar palsy, axial rigidity, bradykinesia, postural instability and dementia. Presence of dementia and lack of cortical histopathology suggest the derangement of cortical function by pathological changes in subcortical structures in PSP, which is supported by the pattern of behavioral changes and measurement of brain metabolism using positron emission tomography. This study was done to examine whether there are specific changes of regional cerebral perfusion in PSP and whether there is a correlation between severity of motor abnorma- ility and degree of changes in cerebral perfusion. We measured regional cerebral perfusion indices in 5 cortical and 2 subcortical areas in 6 patients with a clinical diagnosis of PSP and 6 healthy age and sex matched controls using Tc-99m-HMPAO SPECT. Compared with age and sex matched controls, only superior frontal regional perfusion index was significantly decreased in PSP (p〈0.05). There was no correlation between the severity of the motor abnormility and any of the regional cerebral perfusion indices (p〉0.05). We affirm the previous reports that perfusion in superior frontal cortex is decreased in PSP. Based on our results that there was no correlation between severity of motor abnormaility and cerebral perfusion in the superior frontal cortex, nonmotoric symptoms including dementia needs to be looked at whether there is a correlation with the perfusion abnormility in superior frontal cortex.