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- 저자 : 장지택 ( Jee Taek Jang ) (검색결과 2 건)
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Rat에 sulfamethazine sodium 경구투여 후 시간경과에 따른 혈청, 간장 및 근육내 잔류함유량 변화
도재철 ( Jae Cheul Do ),장지택 ( Jee Taek Jang ),이영미 ( Young Mi Lee ),조종숙 ( Jong Suk Cho ),조민희 ( Min Hee Cho ),박희주 ( Hee Ju Park ),신대길 ( Dae Gil Shin ),정종식 ( Jong Sik Jyeong ) 한국가축위생학회 2000 韓國家畜衛生學會誌 Vol.23 No.2
Sulfamethazine sodium was orally administrated to sprague-dawley strain male rats(body weight, 200-300g) with using sonde at the rate of 20 mg/100g body weight (recommended therapeutic dose) on once a day for 3 days. There were investigated the depletion rate of the suifaniethazine in serum, liver and skeletal muscle of rat at the time 8 hours, 1st, 2nd, 3rd, 4th, 5th and 6th day after administration sulfamethazine sodium. 1. The mean concentrations of sulfamethazine in serum according to the time lapsed after oral administration of the sulfamethazine sodium were showed 215.53 ± 42.99 ppm at the 8 hours after withdrawal of medicated sulfamethazine. And gradually according to the time lapsed, the concentrations of sulfamethazine residues in serum were significantly (p<.05) decreased 25.87 ± 5.18 ppm at 1st day, 2.30 ± 0.61 ppm at 3rd day and 0.11 ± 0.02 ppm at 6th day after withdrawal of medicated sulfamethazine. 2. The mean concentrations of sulfamethazine in liver were significantly (p<.05) decreased 81.77 ± 12.88 ppm to 0.11 ± 0.03 ppm between 8 hours and 6th day according to the time lapsed after oral administration of the sulfamethazine sodium for 3 days. 3. After oral administration of the sulfamethazine sodium, the mean concentrations of sulfamethazine in skeletal muscle were significantly (p<.05) decreased 35.96 ± 1.39 ppm to 0.009 ± 0.001 ppm between 8 hours and 6th day after withdrawal of medicated sulfamethazine.At the 4th day, the concentrations of sulfamethazine residues were showed 0.10 ± 0.04 ppm below 0.1 ppm at the permitted limit concentration of muscle in Korea 4. After oral administration of the sulfamethazine sodium once a day for 3 days, there were showed the highest concentration in serum (215.53 ± 42.99 ppm) than in liver (81.77 ± 12.8 ppm) and skeletal muscle (35.96 ± 1.39 ppm) at the 8 hours after withdrawal of medicated sulfamethazine. The mean concentration of sulfamethazine residues in serum, liver and skeletal muscle were gradually decreased according to the time lapsed.
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Vitamin E 경구투여가 한우 거세비육우의 혈액 및 근육내 지질과산화 작용에 미치는 영향
도재철 ( Jae Cheul Do ),조민희 ( Min Hee Cho ),이영미 ( Young Mi Lee ),장지택 ( Jee Taek Jang ),이양수 ( Yang Soo Lee ),손재권 ( Jae Kwon Son ),송희종 ( Hee Jong Song ),정종식 ( Jong Sik Jyeong ) 한국가축위생학회 1999 韓國家畜衛生學會誌 Vol.22 No.3
This study was evaluated to know the effects of vitamin E(VE) on the lipid peroxidation in blood and sirloin of castrated korean indigenous beef cattle. Experimental groups were divided into VE 500 IU(A), 1,500 IU additative feeding group(B) and non-VE-treated control group(C). After oral administration to the cattle for 120 and 150 days, body weight gains, VE contents in plasma and sirloin, and thiobarbituric acid(TBA) value were examined according to the exhibition period(1-7 days) in refrigerated showcase between aging and non- aging group. The results obtained from this study were summarized as follows; 1. Body weight gain per day of control compared with VE additative feeding A and B groups were showed no significantly differences. 2. The concentrations of VE in plasma after oral administration with VE for 120 days were significantly increased(p<0.05) in A and B groups. There were higher(p<0.05) 4.22μg/mℓ in A and 6.22μg/mℓ in B group than the control(3.0μg/mℓ). And the concentrations of VE in plasma for 150 days were significantly increased(p<0.05) in VE additative feeding groups. There were higher 4.89μg/mℓ in A and 7.05μg/mℓ in B group than the control(3.15μg/mℓ). 3. The concentrations of VE in sirloin for 120 days were significantly increased(p<0.05) in A and B groups. There were higher 1.84μg/g in A group and 2.40μg/g in B group than the control(0.78μg/g). And the concentrations of VE in sirloin for 150 days were significantly increased(p<0.05) in A and B groups. There were higher l.94μg/g in A group and 2.63μg/g in B group than the control(1.00μg/g). 4. TBA values, the indicator of lipid peroxidation, in non-aging sirloin according to the exhibition period(1-7 days) in refrigerated showcase after oral administration with VE additative feed for 120 days were lower 0.73 in A and B groups than 0.82 in control at the third day after exhibition. In the same group, TBA values were significantly(p<0.05) lower 0.77 and 0.75 in A and B groups than 1.22 in control at the seventh day after exhibition. Equally, in the aging group, there were significantly(p<0.05) showed lower TBA values 1.05 and 0.99 in A and B groups than 1.87 in control at the seventh day after exhibition. 5. After oral administration with VE additative feed to the cattle for 150 days, TBA values in non-aging sirloin according to the exhibition period(1-7 days) in refrigerated showcase were significantly(p<0.05) decreased to 0.84 and 0.88 in A and B groups than 1.26 in control at the seventh day after exhibition. In the aging group, there were significantly(p<0.05) showed lower TBA values 0.95 and 0.99 in A and B groups than 1.79 in control at the seventh day after exhibition.
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