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Iridoid Compounds가 RNA 및 Protein 생합성에 미치는 영향
허순옥(S. O. Huh),김제훈(J. H. Kim),장일무(I. M. Chang) 한국생약학회 1985 생약학회지 Vol.16 No.2
To investigate a possible biological activity of iridoid glucosides, six compounds, aucubin, catalpol, gardenoside, geniposide, rehmannioside and swertiamarin, were studied in relation with their potential influences in RNA and protein biosyntheses in murine tumor cell, sarcoma 180, in vitro. Protein biosynthesis was slightly inhibited by aucubin, gardenoside and swertiamarin. Degree of inhibition of RNA biosynthesis by those iridoid appeared to be more sensitive than that of protein biosynthesis. When aucubin was pretreated with β-glucosidase to produce its genin form and the sarcoma 180 cells were exposed to this aucubigenin, the protein and RNA biosyntheses in the cells were profoundly inhibited. The results indicate that a biologically active from of iridoid compounds is the hydrolytic products of glycoside, i.e. genin form. It is also suggested that sarcoma 180 cells used in the experiments appear to lack of β-glucosidase, since the inhibitory actions of iridoid glucosides were so slight that those glucosides were not hydrolysed by the enzyme to their genin forms.
오쿠빈이 Sarcoma 180 암세포 DNA 및 RNA 생합성에 미치는 영향
장경숙,윤혜숙,장일무 ( K . S . Chang,H . S . Yun ( Choi ),I - M . Chang ) 생화학분자생물학회 1983 BMB Reports Vol.16 No.4
Effects of aucubin on DNA and RNA biosyntheses in Sarcoma 180 cells were investigate under in vitro condition. At 1.0 mM concentration, aucubin inhibited about 30 % of RNA biosynthesis, whereas at same concentration it did not appear to exhibit appreciabie inhibitory effect on DNA biosynthesis.
Effects of Aucubin on DNA and RNA Biosyntheses in Sarcoma 180 Cells
장경숙,윤혜숙,장일무,Chang, K.S.,Yun, H.S.,Chang, I.M. 생화학분자생물학회 1983 한국생화학회지 Vol.16 No.4
Iridoid 계열 물질의 하나인 오쿠빈을 식나무(A. japonica)로 부터 분리한 후, 이의 생물활성작용을 조사하였다. 핵산대사 중 Sarcoma 180 암세포에 미치는 영향을 실험한 결과, 암세포 배양액에 0.1 mM, 0.5 mM, 1.0 mM의 오쿠빈을 첨가할 때 1.0 mM에서 약 30%정도 RNA 생합성 억제작용을 보여 주었다. 반면에 1.0 mM의 농도에서 DNA 생합성은 거의 억제를 받지 않았다. Effects of aucubin on DNA and RNA biosyntheses in Sarcoma 180 cells were investigate under in vitro condition. At 1.0 mM concentration, aucubin inhibited about 30% of RNA biosynthesis, whereas at same concentration it did not appear to exhibit appreciabie inhibitory effect on DNA biosynthesis.
이종흔(J. H. Lee),김중수(J. S. Kim),김제훈(J. H. Kim),장일무(I. M. Chang) 한국생약학회 1980 생약학회지 Vol.11 No.1
Siegesbeckia pubescens, $quot;Hi-cheom$quot;, has long been used for antihypertensive agent as a folkloric drug in Korea. Recently, the Compound B, one of diterpene compounds were isolated and determined its chemical structure. The present study is aimed to evaluated antihypertensive activities of the Compound B against the animal model of high blood rat, Okamodo-SHR. The Okamodo-SHR rats were divided into three groups. One group as a control received propranolol, known β-Blocker and the other two group received the Compound B with dose ranges from 20∼50㎎/㎏/day. The blood pressure of rats were measured by using electro-spygmograph having special attachment of pneumatic pulse transducer. It was noted that the Compound B appoared to possess the antihypertensive activities.