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Vitamin or Its Derivatives and Skin Barriers
장용현 ( Yong Hyun Jang ) 한국피부장벽학회 2019 한국피부장벽학회지 Vol.21 No.1
The skin barrier plays key roles in immune surveillance and homeostasis, and in preventing penetration of microbial products and allergens. Common inflammatory skin disorders such as atopic dermatitis and psoriasis exhibit decreased barrier function, and recent studies suggest that the complex response of epidermal cells to barrier disruption may aggravate, maintain, or even initiate such conditions. Either aiding barrier reestablishment or dampening the epidermal stress response may improve the treatment of these disorders. Nutrition is one of many factors needed for the maintenance of skin homeostasis. Poor nutritional status alters the structural deformation and skin barrier integrity, which in turn leads to an impaired biological function of the skin. The importance of micronutrients (such as certain vitamins and minerals) to skin health has been emphasized in vitro and in vivo. These micronutrients are not only active compounds of treatment to treat certain skin diseases such as atopic dermatitis and psoriasis but are also used as ingredients for cosmetics. The goal of this review is to discuss the potential roles and current knowledge of selected micronutrients (vitamin and its derivatives) in skin health and cutaneous barrier function.
장용현 ( Yong Hyun Jang ),김도원 ( Do Won Kim ) 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.1
The clinical course of alopecia areata (AA) is unpredictable. Up to 50% of patients will recover within a year without treatment. However, the majority of AA patients will show an irregular relapsing-remitting course, with multiple episodes of hair loss. The major prognostic factors with clinical relevance include the extent and duration of disease. Many therapeutic options exist for AA and the recommended treatment strategies are based on the age of the patient and the extent of disease. Therapeutic modalities include topical minoxidil, topical and intralesional corticosteroids for mild AA, and diphenylcyclopropenone (DPCP) for severe AA. Unfortunately, to date, there is no approved cure that provides complete hair regrowth, and all treatments are considered “off-label”. For many reasons, including a high rate of spontaneous remission and paucity of randomized-controlled studies investigating treatment efficacy, it is difficult to assess therapeutic effects for AA. Moreover, long-term follow-up is not reported in many of the publications. Another important drawback is the great variation in treatment outcome evaluation. To minimize this factor, the Severity of Alopecia Tool (SALT) score has been used as a method for measuring the extent of scalp AA. Recently, we introduced the Alopecia Areata Progression Index (AAPI) which seems to represent a system capable of quantifying overall hair loss activity in AA patients with different severity. In this review, we discuss the clinical course, prognosis, evaluation of treatment, and measuring tools of AA. (Korean J Dermatol 2018;56(1):10∼16)
장용현 ( Yong Hyun Jang ),최윤혁 ( Yoon Hyuk Choi ),김준영 ( Jun Young Kim ),김호연 ( Ho Youn Kim ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Self-regression of Kaposi`s sarcoma is rare with the exception of the iatrogenic immunosuppressive type. No cases of classic type Kaposi`s sarcoma showing spontaneous regression have been reported in the Korean dermatologic literature. We report a case of classic type of Kaposi`s sarcoma in a 69-year-old man which followed a clinical course of spontaneous regression. He presented with multiple asymptomatic beefy red papules and nodules scattered on both cheeks and upper extremities during a state of increase in the number of skin lesions at the initial visit. He had no history of immunosuppressive treatment and the laboratory findings were unremarkable. An anti-HIV antibody test was negative. A histopathologic examination revealed typical findings of Kaposi`s sarcoma and positive staining with CD31 and D2-40. HHV-8 DNA was detected in a biopsy specimen. Without any specific treatment, the skin lesions healed without leaving any complications after 15 months, and did not show any evidence of recurrence during the ensuing 5 years.