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임영혁(Young Hyuk Im),이제환(Je Hwan Lee),정경해(Kyung Hae Jung),강윤구(Yoon Koo Kang),박근칠(Keun Chil Park),신동복(Dong Bok Shin),이재훈(Jae Hoon Lee),허대석(Dae Seog Heo),박선양(Seon Yang Park),김병국(Byoung Kook Kim),김노경(Noe K 대한내과학회 1990 대한내과학회지 Vol.39 No.4
N/A Twenty-one previously untreated patients with acute lymnocytic leukemia were treated with induction chemotherapy consisting of vincristine, prednisolone, daunorubicin, and L-asparaginase. After sucessful remission induction, CNS prophylaxis was performed with cranial irradiation and intrathecal methotrexate, and alternating chemotherapy with non-cross-resistnat agents was used in consolidation therapy. The results were as follows; 1) Fifteen out of 18 (83.3%) cases achieved complete remission, and the median duration of remission was 26.8 weeks (4-111+weeks). 2) The overall median survival of the patients was 24.8 weeks (2-120+ weeks). 3) The median survival of the responders was longer than that of the nonresponders (38 weeks vs four weeks). 4) The only favorable factor influencing the remission rate was age below 20 years (p<0.05), and the favorable prognostic factor for remission duration was time to remission (<four weeks). 5) Sevent out of 15 (47%) patients in remission suffered relapse, and the sites of relapse were the bone marrow and central nervous system. 6) Non-hematologic toxicities during induction chemotherapy were hepatotoxicity (such as jaundice, elevation of hepatic enzymes, and glucose intolerance), mainly due to L-asparaginase: hematologic toxicities were tolerable. In conclusion, this induction regimen was useful in terms of remission rate, however, it was thought to be ineffective because of the considerable number of side effects and the shortness of the remission duration.
개심술(開心術)의 임상적 고찰 : 치험 200예 200 Cases
최형호,서홍주,임영혁,김정중,배대양,이석기,임진수 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2
Background and Objectives: Two hundred cases of the open heart surgery due to congenital and acquired heart disease were done using the cardiopulmonary bypass in the Department of Thoracic and Cardiovascular surgery, Chosun University Hospital from November, 1980 to June, 2001. Material and Methods: The number of congenital heart disease was 132 cases. 68 cases were acquired heart disease. 'The age of the congenital heart disease was from 22 days to 45 years. In the acquired heart disease, the age was from 14 to 72 years. Result: Congenital heart disease consisted of 113 congenital acyanotic heart disease, 19 congenital cyanotic heart disease. Corrective operation was done for congenital heart disease with 4. 5 % operative mortality. Of 68 cases acquired heart disease, 44 patients were valvular heart disease, 3 cardiac tumors, 9 ischemic heart diseases, 12 aortic dissections and etc. The operative mortality was 13%. Conclusion: The postoperative complications were appeared in 68 cases and the complications were wound infection, occipital alopecia, low cardiac output syndrome, arrhythmia, septicemia etc. The mortality after open heart surgery was 15 cases and the causes of death were low cardiac output syndrome, septicemia, respiratory failure and left ventricle rupture.
최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.